Global experts convened in Beijing to discuss how researchers might burst through the constraints of Moore’s Law, to allow ever faster and greener computing.
Category: futurism – Page 11
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Brynn Bateman unveiled the New Yokosuka project.
Abstract: IFN signaling at the nexus of the radiotherapy response in malignant peripheral nerve sheath tumors:
Sean P. Pitroda & Ralph R. Weichselbaum provide a Commentary on Iowis Zhu et al.: https://doi.org/10.1172/JCI195652
Address correspondence to: Ralph Weichselbaum, Department of Radiation and Cellular Oncology, The University of Chicago, 5,758 S. Maryland Ave., Chicago, Illinois 60,637, USA.
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Department of radiation and cellular oncology, the university of chicago, chicago, illinois, USA.
Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors
Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-α3. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.
Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report from the National Clinical Trials Network
Read it in the RedJournal: @NRGOnc
: Intensity-modulated radiation therapy (IMRT) is increasingly used for total body irradiation (TBI) due to its ability to deliver myeloablative doses while sparing radiosensitive organs. To enable consistent evaluation in future National Clinical Trials Network (NCTN) studies, the xxx Hematologic Malignancies Working Group (HMWG) convened IMRT-TBI experts and NCTN leaders to develop consensus recommendations for standardized multi-institutional implementation.
Why conversation is more like a dance than an exchange of words
Think about the last time you told a story to a friend. You probably adjusted it halfway through. You saw their eyebrows lift. You noticed them lean in, or glance away. You clarified a detail. You sped up the ending. That constant fine-tuning is not a bonus feature of communication: it is communication. And you can read all about this real-time coordination process in a new review by Judith Holler and Anna K. Kuhlen (Max Planck Institute for Psycholinguistics), published in Nature Reviews Psychology.
Holler and Kuhlen argue that conversation is not simply one person speaking while another listens. It is a process in which both participants continuously monitor, predict, and shape each other’s behavior. “Conversation is not a linear exchange of words,” Holler writes. “It is a jointly managed activity in which meaning emerges through coordination.”