Lifeboat Foundation

Computers have been digital for half a century. Why would anyone want to resurrect the clunkers of yesteryear?

Advances in antiaging drug/lead discovery in animal models constitute a large body of literature on novel senotherapeutics and geroprotectives. However, with little direct evidence or mechanism of action in humans—these drugs are utilized as nutraceuticals or repurposed supplements without proper testing directions, appropriate biomarkers, or consistent in-vivo models. In this study, we take previously identified drug candidates that have significant evidence of prolonging lifespan and promoting healthy aging in model organisms, and simulate them in human metabolic interactome networks. Screening for drug-likeness, toxicity, and KEGG network correlation scores, we generated a library of 285 safe and bioavailable compounds. We interrogated this library to present computational modeling-derived estimations of a tripartite interaction map of animal geroprotective compounds in the human molecular interactome extracted from longevity, senescence, and dietary restriction-associated genes. Our findings reflect previous studies in aging-associated metabolic disorders, and predict 25 best-connected drug interactors including Resveratrol, EGCG, Metformin, Trichostatin A, Caffeic Acid and Quercetin as direct modulators of lifespan and healthspan-associated pathways. We further clustered these compounds and the functionally enriched subnetworks therewith to identify longevity-exclusive, senescence-exclusive, pseudo-omniregulators and omniregulators within the set of interactome hub genes. Additionally, serum markers for drug-interactions, and interactions with potentially geroprotective gut microbial species distinguish the current study and present a holistic depiction of optimum gut microbial alteration by candidate drugs. These findings provide a systems level model of animal life-extending therapeutics in human systems, and act as precursors for expediting the ongoing global effort to find effective antiaging pharmacological interventions.

Communicated by Ramaswamy H. Sarma.

Scientists have devised a way of fabricating a complex structure, previously found only in nature, to open up new ways for manipulating and controlling light.

The structure, which naturally occurs in the wing scales of some species of butterfly, can function as a photonic crystal, according to a new study by researchers at the University of Birmingham. It can be used to control light in the visible range of the spectrum, for applications for lasers, sensors, and also devices for harvesting solar energy.

Their computational study, published in Advanced Materials, demonstrates that the complex gyroid structure can be self-assembled from designer colloidal particles in the range of hundreds of nanometers.

Superconductors make highly efficient electronics, but the ultralow temperatures and ultrahigh pressures required to make them work are costly and difficult to implement. Room-temperature superconductors promise to change that.

The recent announcement by researchers at the University of Rochester of a new material that is a superconductor at room temperature, albeit at high pressure, is an exciting development – if proved. If the material or one like it works reliably and can be economically mass-produced, it could revolutionize electronics.

Continue reading “Room-temperature superconductors could revolutionize electronics — an electrical engineer explains the materials’ potential” »

In my latest interview, I answer some questions on the fascinating topic of synthetic telepathy. Recently, the concept of synthetic telepathy has gained increasing attention from both the scientific community and the general public. The ability to communicate with others using only our thoughts may sound like something straight out of science fiction, but recent advancements in neuroscience and technology have brought us closer to making this a reality.

#SyntheticTelepathy #neurotechnology #braincomputerinterface #BCI #cybernetics #brainhacking #mindcontrol #nanocybernetics

In recent years, the concept of synthetic telepathy has gained increasing attention from both the scientific community and the general public. The ability to communicate with others using only our thoughts may sound like something straight out of science fiction, but recent advancements in neuroscience and technology have brought us closer to making this a reality. Join us for an exclusive interview with futurist and evolutionary cyberneticist Alex M. Vikoulov, as he shares his expertise on the fascinating topic of synthetic telepathy. Speaking with news reporter Blanca Elena Reyes, Vikoulov will delve into the workings of this cutting-edge technology and discuss its potential applications for the future.

Continue reading “Synthetic Telepathy: The Revolutionary Technology Redefining Communication” »

Do you really want to live forever? Futurist Ray Kurzweil has predicted that humans will achieve immortality in just seven years. Genetic engineering company touts ‘Jurassic Park’-like plan to ‘de-extinct’ dodo bird Elon Musk ‘comfortable’ putting Neuralink chip into one of his kids.

Read more ❯.

A nonreciprocal critical current is known as the superconducting diode effect (SDE). Here, the authors use SQUID-on-tip to study SDE in a EuS/Nb bilayer and find that the stray field from magnetized EuS creates screening currents in the Nb, which lead to SDE by affecting vortex flow dynamics.

Researchers at University of Oxford have recently created a quantum memory within a trapped-ion quantum network node. Their unique memory design, introduced in a paper in Physical Review Letters, has been found to be extremely robust, meaning that it could store information for long periods of time despite ongoing network activity.

“We are building a network of quantum computers, which use trapped ions to store and process quantum information,” Peter Drmota, one of the researchers who carried out the study, told Phys.org. “To connect quantum processing devices, we use single photons emitted from a single atomic ion and utilize quantum entanglement between this ion and the photons.”

Trapped ions, charged atomic particles that are confined in space using electromagnetic fields, are a commonly used platform for realizing quantum computations. Photons (i.e., the particles of light), on the other hand, are generally used to transmit quantum information between distant nodes. Drmota and his colleagues have been exploring the possibility of combining trapped ions with photons, to create more powerful quantum technologies.

Macromolecular machines acting on genes are at the core of life’s fundamental processes, including DNA replication and repair, gene transcription and regulation, chromatin packaging, RNA splicing, and genome editing. Here, we report the increasing role of computational biophysics in characterizing the mechanisms of “machines on genes”, focusing on innovative applications of computational methods and their integration with structural and biophysical experiments. We showcase how state-of-the-art computational methods, including classical and ab initio molecular dynamics to enhanced sampling techniques, and coarse-grained approaches are used for understanding and exploring gene machines for real-world applications.