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Category: chemistry – Page 81

Worm surface chemistry reveals secrets to their development and survival

A new study has revealed the clearest-ever picture of the surface chemistry of worm species that provides insights into how animals interact with their environment and each other. These discoveries could pave the way for strategies to deepen our understanding of evolutionary adaptations, refine behavioral research, and ultimately overcome parasitic infections.

Scientists from the University’s School of Pharmacy used an advanced mass spectrometry imaging system to examine the nematodes Caenorhabditis elegans and Pristionchus pacificus, aiming to characterize species-specific surface and its roles in physiology and behavior.

Their results show that nematode surfaces are predominantly oily or lipid-based, forming a complex chemical landscape. The findings have been published in theJournal of the American Chemical Society.

Quantum Imaging Just Got Faster, Smaller, and More Precise

A team of scientists has unlocked a new frontier in quantum imaging, using a nanoscale.

The term “nanoscale” refers to dimensions that are measured in nanometers (nm), with one nanometer equaling one-billionth of a meter. This scale encompasses sizes from approximately 1 to 100 nanometers, where unique physical, chemical, and biological properties emerge that are not present in bulk materials. At the nanoscale, materials exhibit phenomena such as quantum effects and increased surface area to volume ratios, which can significantly alter their optical, electrical, and magnetic behaviors. These characteristics make nanoscale materials highly valuable for a wide range of applications, including electronics, medicine, and materials science.

Solving the drug solubility problem with silica nanoparticles

Harvard University and the Chinese University of Hong Kong researchers have developed a technique that increases the solubility of drug molecules by up to three orders of magnitude. This could be a breakthrough in drug formulation and delivery.

Over 60% of pharmaceutical drug candidates suffer from poor water solubility, which limits their bioavailability and therapeutic viability. Conventional techniques such as particle-size reduction, solid dispersion, lipid-based systems, and mesoporous confinement often have drug-specific limitations, can be costly to implement, and are prone to stability issues.

The newly developed approach addresses these issues by leveraging the competitive adsorption mechanism of drug molecules and water on engineered silica surfaces. It avoids chemical modification of drug molecules or using additional solubilizing agents to achieve solubility, potentially replacing multiple drug delivery technologies.

Physicists stabilize superconducting states at ambient pressure

Researchers at the University of Houston’s Texas Center for Superconductivity have achieved another first in their quest toward ambient-pressure high-temperature superconductivity, bringing us one step closer to finding superconductors that work in everyday conditions—and potentially unlocking a new era of energy-efficient technologies.

In their study titled “Creation, stabilization, and investigation at of pressure-induced superconductivity in Bi0.5 Sb1.5 Te3,” published in the Proceedings of the National Academy of Sciences, professors Liangzi Deng and Paul Ching-Wu Chu of the UH Department of Physics set out to see if they could push Bi0.5 Sb1.5 Te3 (BST) into a under pressure—without altering its chemistry or structure.

“In 2001, scientists suspected that applying high pressure to BST changed its Fermi surface topology, leading to improved thermoelectric performance,” Deng said. “That connection between pressure, topology and superconductivity piqued our interest.”

Gardenia Plants may hold Chemical Key to Regenerating Diseased Human Nerves

Gardenias are known for their rich, earthy fragrance, waxy petals and brilliant white color that contrasts with the deep emerald green of their leaves. The plant has long been prized by herbalists, seekers of food and fabric dyes, and even pharmaceutical companies.

Now, a collaborative team of scientists at several research centers in the United States has found that a compound known as genipin, derived from the gardenia plant called Cape jasmine, can prompt nerve regeneration. Neurons damaged and stunted by disease find new life in the lab when exposed to the plant-derived compound.

The chemical comes from the fruit of this extraordinarily versatile plant. Gardenia shrubs, in general, are native to tropical and subtropical regions of Asia. But the plants are propagated globally by horticulturists and amateur gardeners who are most familiar with the flower’s beauty and the intoxicating scent of their perfume.

Alan Love — Philosophy of Reductionism & Emergence

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Can biology be explained entirely in terms of chemistry and then physics? If so, that’s “reductionism.” Or are there “emergent” properties at higher levels of the hierarchy of life that cannot be explained by properties at lower or more basic levels?

Alan C. Love, Ph.D., is a professor in the College of Liberal Arts at the University of Minnesota. He also serves as director of the Minnesota Center for Philosophy of Science.

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Researchers Discover Simple Solution To Break Down “Forever” Chemicals

Per-and polyfluoroalkyl substances (PFAS) are industrial chemicals used in the manufacturing of thousands of products, including cosmetics, carpeting, non-stick cookware, stain-resistant fabrics, firefighting foams, food packaging, and waterproof clothing.

They’re everywhere — the environment, our food, and even in our bodies. Peer-reviewed studies have shown that exposure to PFAS may lead to decreased fertility, developmental delays in children, and increased risk of some cancers. And they take hundreds or even thousands of years to break down.

For roughly the past 10 years, researchers have been looking for ways to remove PFAS from the environment or at least degrade them into harmless, inorganic compounds.

Self-driving lab for the photochemical synthesis of plasmonic nanoparticles with targeted structural and optical properties

The automated synthesis of plasmonic nanoparticles with on-demand properties is a challenging task. Here the authors integrate a fluidic reactor, real-time characterization, and machine learning in a self-driven lab for the photochemical synthesis of nanoparticles with targeted properties.

A New Kind of Epigenetic Gene Control is Revealed

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, and they do so without altering the sequence of genes. These may involve chemical groups like methyl tags that adorn DNA, or structural characteristics that relate to proteins that organize DNA. But scientists have also been learning about how epigenetics affect RNA. New findings on a balancing act in epigenetics, which works on DNA and RNA, have been reported in Cell.

When genes are expressed, they are transcribed into messenger RNA (mRNA) molecules. The cell can then translate those mRNA molecules into proteins, which carry out a variety of functions. Scientists have identified an epigenetic mechanism that seems to balance gene expression. One facet of the mechanism can promote the transcription and organization of genes, while the other causes mRNA transcripts to lose stability, and can adjust how those transcripts are used. This work has shown that DNA and RNA epigenetics may be more closely linked than known.

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