Researchers have developed nano-scale drills that kill bacteria by drilling holes into their membranes. They are powered by visible light.
Electric organs help electric fish, such as the electric eel, do all sorts of amazing things: They send and receive signals that are akin to bird songs, helping them to recognize other electric fish by species, sex and even individual. A new study in Science Advances explains how small genetic changes enabled electric fish to evolve electric organs. The finding might also help scientists pinpoint the genetic mutations behind some human diseases.
Evolution took advantage of a quirk of fish genetics to develop electric organs. All fish have duplicate versions of the same gene that produces tiny muscle motors, called sodium channels. To evolve electric organs, electric fish turned off one duplicate of the sodium channel gene in muscles and turned it on in other cells. The tiny motors that typically make muscles contract were repurposed to generate electric signals, and voila! A new organ with some astonishing capabilities was born.
“This is exciting because we can see how a small change in the gene can completely change where it’s expressed,” said Harold Zakon, professor of neuroscience and integrative biology at The University of Texas at Austin and corresponding author of the study.
A study reveals one of the reasons why neurons die in Parkinson’s patients
According to World Health Organization (WHO) estimates, around 7 million individuals worldwide suffer from Parkinson’s disease. Although the origins of this neurodegenerative disorder are not entirely understood, it is known that many of its symptoms are caused by the death of neurons that create dopamine.
A study conducted in mice by a research team at the University of Cordoba has uncovered one of the causes of this neuronal loss: the key resides in the protein called DJ1, whose association with Parkinson’s disease has previously been established, but its specific role was unknown until now.
A new technology is using particles of gold to make colors. With further work, the method developed at Aalto University could herald a new display technology.
The technique uses gold nanocylinders suspended in a gel. The gel only transmits certain colors when lit by polarized light, and the color depends on the orientation of the gold nanocylinders. In a clever twist, a collaboration led by Anton Kuzyk’s and Juho Pokki’s research groups used DNA molecules to control the orientation of gold nanocylinders in the gel.
“DNA isn’t just an information carrier—it can also be a building block. We designed the DNA molecules to have a certain melting temperature, so we could basically program the material,” says Aalto doctoral candidate Joonas Ryssy, the study’s lead author. When the gel heats past the melting temperature, the DNA molecules loosen their grip and the gold nanocylinders change orientation. When the temperature drops, they tighten up again, and the nanoparticles go back to their original position.
When a donor organ becomes available to someone in need of a transplant, medical personnel need to act quickly. It only takes a few hours for expanding ice crystals to damage delicate tissue, leaving a window of less than 12 hours to assess, transport, and implant the new organ.
This not only creates a tremendous time crunch to perform a delicate procedure, but leaves many organs unviable for transplantation.
But a new breakthrough could vastly improve the landscape of liver transplantation: Scientists kept a liver preserved for three days, in non-frozen conditions, before transplanting it into a patient.
If I’ve been reading the articles right, progeria may be cured soon. Really amazing.
Advances in gene editing have brought us ever closer to fixing some of the most devastating diseases of our time, such as progeria and sickle cell disease.
Is it all down to a cup of joe then?
People who drink coffee regularly, with or without sugar, both seem to benefit from the beverage as it cuts down on the risk of early death, * The Guardian* reported.
Grabbing a cup of coffee may just be something you do almost unconsciously as you sit down with your morning newspaper or before you start your workday. As the day wears on, you might be down three cups or maybe even five without giving it a second thought. However, scientists have been very conscious of the world’s coffee consumption.
Continue reading “Coffee drinkers have a 29 percent lower risk of death than non-coffee drinkers” »
Using a new gene therapy technique, researchers at the University of California San Diego reduced neuropathic pain resulting from spinal cord or other nerve injuries in mice — and with no detectable side effects.
The research is highly intriguing because it could lead to new treatment options for the untold numbers of patients who experience chronic pain, numbness or weak muscles as a result of spinal cord injuries.
Treating nerve damage or dysfunction, otherwise known as neuropathy, with drugs can often lead to side effects. These drugs also have to be administered continuously, and opioids — which are particularly effective painkillers — can often lead to addiction issues.
Background An attempt was made to reprogram peripheral blood cells into human induced pluripotent stem cell (hiPSCs) as a new cell source for cartilage repair. Methods We generated chondrogenic lineage from human peripheral blood via hiPSCs using an integration-free method. Peripheral blood cells were either obtained from a human blood bank or freshly collected from volunteers. After transforming peripheral blood cells into iPSCs, the newly derived iPSCs were further characterized through karyotype analysis, pluripotency gene expression and cell differentiation ability. iPSCs were differentiated through multiple steps, including embryoid body formation, hiPSC-mesenchymal stem cell (MSC)-like cell expansion, and chondrogenic induction for 21 days. Chondrocyte phenotype was then assessed by morphological, histological and biochemical analysis, as well as the chondrogenic expression.
