Lifeboat Foundation

DNA can be utilized to reliably store massive amounts of digital data. However, it has hitherto proven challenging to retrieve or manipulate the specific data embedded in these molecules. Now, scientists from the CNRS and the University of Tokyo have developed the use of a novel enzyme-based technique, providing the initial clues as to how these technical obstacles may be overcome. Their research was recently published in the journal Nature.

Nature has unquestionably developed the best method for massive data storage: DNA. Based on this knowledge, DNA has been used to store digital data by translating binary (0 or 1) values into one of the four different DNA “letters” (A, T, C, or G).

But how can one search through the database of data encoded in DNA to discover a certain datum? And how is it possible to execute computations using DNA-encoded data without first transforming it into electronic form? These are the questions that research teams from the LIMMS (CNRS / University of Tokyo) and Gulliver (CNRS / ESPCI) laboratories have attempted to answer. They are experimenting with a new approach using enzymes and artificial neurons and neural networks for direct operations on DNA data.

21 oct 2022.

Adolescent (or juvenile) delinquency is defined as the habitual engagement in unlawful behavior of a minor under the age of majority. According to studies, the likelihood of acquiring a deviant personality increases significantly during adolescence. As a result, identifying deviant youth early and providing proper medical counseling makes perfect sense. Due to the scarcity of qualified clinicians, human appraisal of individual adolescent behavior is subjective and time-consuming. As a result, a machine learning-based intelligent automated system for assessing and grading delinquency levels in teenagers at an early stage must be devised.

Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.

Using this system, the researchers showed that they could deliver genes as long as 36,000 DNA base pairs to several types of human cells, as well as to liver cells in mice. The new technique, known as PASTE, could hold promise for treating diseases that are caused by defective genes with a large number of mutations, such as cystic fibrosis.

“It’s a new genetic way of potentially targeting these really hard to treat diseases,” says Omar Abudayyeh, a McGovern Fellow at MIT’s McGovern Institute for Brain Research. “We wanted to work toward what gene therapy was supposed to do at its original inception, which is to replace genes, not just correct individual mutations.”

Some neuroscience studies suggest that distinct human emotional states are associated with greater activity in different regions of the brain. For instance, while some parts of the brain have been associated with all emotional responses, the hypothalamus has often been linked to sexual responses and feelings of intimacy, the hippocampus to the retrieval of emotion-eliciting memories, and the amygdala to fear and anger.

Humans can experience emotional responses to an extremely wide range of sensory and environmental stimuli, including the food they consume. So far, however, relatively few studies have explored the link between emotional states elicited by different food flavors and activity in different parts the cortex (i.e., the part of the brain responsible for higher cognitive processes).

Researchers at Niigata University, Hyogo College of Medicine, Meiji University, the Sakagami Dental Clinic and Otemae Junior College have recently carried out a study investigating the emotional responses elicited by differently flavored chewing gums and the cortical activity associated with these responses. Their findings, published in Frontiers in Neuroscience, highlight the potential role of the left prefrontal cortex in eliciting emotional states during the consumption of palatable (i.e., pleasant-tasting) or less flavorful foods.

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Today, with the rampant spread of cybercrime, there is a tremendous amount of work being done to protect our computer networks — to secure our bits and bytes. At the same time, however, there is not nearly enough work being done to secure our atoms — namely, the hard physical infrastructure that runs the world economy.

Nations are now teeming with operational technology (OT) platforms that have essentially computerized their entire physical infrastructures, whether it’s buildings and bridges, trains and automobiles or the industrial equipment and assembly lines that keep economies humming. But the notion that a hospital bed can be hacked — or a plane or a bridge — is still a very new concept. We need to start taking such threats very seriously because they can cause catastrophic damage.

Summary: A new study links daily eating to mortality risk. Those over 40 who eat one meal a day have a higher mortality risk. Those who skip breakfast are at an increased risk of cardiovascular disease-associated death, and those who eat meals less than 4.5 hours apart have increased mortality risks.

Source: Elsevier.

Eating only one meal per day is associated with an increased risk of mortality in American adults 40 years old and older, according to a new study in the Journal of the Academy of Nutrition and Dietetics.

The finding could have implications on drug development beyond neuroscience.

A new study conducted by researchers at the University of Copenhagen has found that V-ATPase, an enzyme thought to be a key component of brain function, switches off randomly, even for hours at a time. This discovery has the potential to change our understanding of how our brain functions, according to a press release.

V-ATPase is an enzyme that can break down ATP molecules, the cell’s energy currency, as they pump protons across cellular membranes.

Continue reading “A key enzyme in brain function shuts off randomly, study reveals” »

It could actually be cheaper than other treatment options.

The U.S. Food and Drug Administration (FDA) recently approved a new drug Hemgenix, to be used in patients with hemophilia B, a blood clotting disorder. Since the condition is rare, it will be used only in a small group of patients worldwide.

Motortion/iStock.

Continue reading “FDA just approved the world’s most expensive drug that costs $3.5 million” »

The first blood test to diagnose inflammation of the heart muscle (myocarditis) could be in use in as little as a year, following the discovery of a molecular signal in the blood by Queen Mary University of London researchers. The research, published today in the journal Circulation, offers hope of a quick and cheap way of diagnosing the condition.

Myocarditis is a difficult condition to diagnose. Symptoms include a temperature, fatigue, chest pain and shortness of breath, which can all be easily mistaken for other conditions. The gold standard method for diagnosis is a heart biopsy, an expensive, invasive, and risky procedure which can sometimes still miss signs of the condition. It’s estimated that one young person dies suddenly every week in the UK due to previously undiagnosed myocarditis.

Now, a team of researchers led by BHF Professor Federica Marelli-Berg at Queen Mary University of London have found that the presence of T-cells—a type of white blood cell—expressing a molecule called cMet in the blood strongly indicates that a person has myocarditis. They say that cMet-expressing T cells levels could be detected through a routine blood test that could cost less than £50 with results available within hours.