Lifeboat Foundation

Orally administered collagen peptides could contribute to antiaging by replacing the degraded extracellular matrix proteins caused by photoaging. This study aimed to evaluate the efficacy and safety of low-molecular-weight collagen peptides for treating photoaged and dry skin. In this randomized, placebo-controlled, parallel-group, double-blinded trial, we randomly assigned study participants (n = 100) to either the test product group or placebo group at a 1:1 ratio for 12 weeks. The wrinkle scale score, eye wrinkle volume, roughness parameters, such as the average maximum height of the wrinkle (Rz), arithmetic average within the total measuring length of the wrinkle (Ra), maximum profile valley depth of the wrinkle (Rv), and skin hydration, transepidermal water loss (TEWL), overall elasticity (R2), and ratio of elastic recovery to total deformation (R7) were evaluated at baseline, 6 weeks, and 12 weeks. Safety assessments with serial blood tests were also conducted. Efficacy assessments of data from 84 participants were conducted as the per-protocol analysis. After 12 weeks, the 10-grade crow’s feet photo scale score, eye wrinkle volume, skin roughness parameters (Rz, Ra, and Rv), skin elasticity (R2 and R7), skin hydration, and TEWL were significantly improved in the test product group compared to the placebo group. There were no adverse events or abnormalities according to laboratory analysis associated with using the test material during the study period. This study showed that the oral supplementation of low-molecular-weight collagen peptides could improve the wrinkles, elasticity, hydration, and barrier integrity of photoaged facial skin. This clinical study was registered with the Korean Clinical Research Information Service and International Clinical Trials Registry Platform (No: KCT0006500).

Keywords: clinical study; collagen peptide; photoaging; wrinkles.

Rationally designed bioinks enable bioprinting of mechanically and physiologically relevant vascular conduits.

Dec 13, 2022 — There are several different types of stem cells, each with its own unique properties and applications in medical research and practice.

A new human study shows that a collagen supplement significantly reduced wrinkles around the eyes after only 12 weeks of treatment.

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Continue reading “New Collagen Human Study Shows Skin Age Reversal!” »

Atherosclerosis is a cardiac-based disease where plaque builds up inside the body’s arteries, the blood vessels responsible for carrying oxygen-rich blood to the heart and other organs of the body. Plaque is made up of immune blood cells, known as macrophages, fat, cholesterol, calcium, and other substances found in the blood.

As this plaque hardens it narrows the arteries, limiting the flow of oxygen-rich blood around the body. This, in turn, can lead to serious problems, including heart attack, stroke, or even death.

Now, a study from researchers led by Michigan State University engineers a nanoparticle capable of eating away, from the inside out, heart attack causing plaques. The team states their nanoparticle reduces and stabilizes plaque, providing a potential treatment for atherosclerosis, a leading cause of death in the United States. The study is published in the journal Nature Nanotechnology.

A new smart skin developed at Stanford University might foretell a day when people type on invisible keyboards, identify objects by touch alone, or allow users to communicate by hand gestures with apps in immersive environments.

In a just-publish paper in the journal Nature Electronics the researchers describe a new type of stretchable biocompatible material that gets sprayed on the back of the hand, like suntan spray. Integrated in the mesh is a tiny electrical network that senses as the skin stretches and bends and, using AI, the researchers can interpret myriad daily tasks from hand motions and gestures. The researchers say it could have applications and implications in fields as far-ranging as gaming, sports, telemedicine, and robotics.

Continue reading “Spray-on smart skin uses AI to rapidly understand hand tasks” »

The findings, published in the Journal of Neuroscience, may help explain how humans form memories and learn, and could eventually aid the development of assistive tools for people affected by neurologic disease or injury. The study was conducted by Massachusetts General Hospital in collaboration with colleagues at Brown University, the Department of Veterans Affairs, and several other institutions.

By MGH news and public affairs.

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Thanks to a new experimental gene therapy, one teen’s previously incurable leukemia is now entirely undetectable, marking an incredible breakthrough in genetic immunotherapies. Alyssa, 13, from Leicester in the UK, was told that the only remaining options were end-of-life care to ensure she was comfortable as the aggressive T-cell acute lymphoblastic leukemia took hold – but the experimental CAR-T base editing therapy was able to modify her immune system to clear all detectable cancer cells.

T-cell lymphoblastic leukemia is a type of cancer that affects T-lymphocytes, an immune white blood cell that is created in the bone marrow. In this type of fast-moving leukemia, these cells divide uncontrollably and enter the bloodstream, traveling to the liver, spleen, and lymph nodes. This can cause death in a short span of just months or even weeks without treatment.

Continue reading “Experimental Gene Therapy Cures Teen’s ‘Incurable’ Cancer” »

‘Most complicated therapy ever’ tailors bespoke, genome-edited immune cells to attack tumours.