Lifeboat Foundation

A variety of healthy eating patterns are linked to reduced risk of premature death, according to a new study led by Harvard T.H. Chan School of Public Health researchers. They found that participants who scored high on adherence to at least one of four healthy eating patterns were less likely to die during the study period from any cause and less likely to die from cardiovascular disease, cancer, or respiratory disease, compared with people with lower scores. The findings are consistent with the current Dietary Guidelines for America, which recommend multiple healthy eating patterns.

“The Dietary Guidelines for Americans are intended to provide science-based dietary advice that promotes good health and reduces major chronic diseases. Thus, it is critical to examine the associations between DGAs-recommended dietary patterns and long-term health outcomes, especially mortality,” said corresponding author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology and chair of the Department of Nutrition.

The study will be published online January 9, 2023, in JAMA Internal Medicine.

A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in test mice and the development of age-related macular degeneration. Kevin Mangum and Katherine Gallagher with the University of Michigan have published a Perspectives piece in the same journal issue outlining the research.

Age-related macular degeneration (AMD) in older people can lead to permanent blindness. Prior research has shown obesity plays a major role in its development. Other research has also shown that AMD is a neuroinflammatory condition. It is believed that the inflammation in the eyes is related to obesity, but the exact connection has not been identified. In this new effort, the researchers sought to find the connection by studying obesity and macular degeneration in mice.

The work involved feeding test mice a high-fat diet and studying the impact on adipose tissue macrophages (types of white blood cells that are part of the immune system). They found that obesity in mice led to epigenetic changes in the macrophages that resulted in an increase in expression of genes that incite an inflammatory response. They also found that the increased expression continued even after the test mice were put on a reduced diet that allowed them to return to their normal weight.

Needs work.

AN ultrarealistic AI robot has opinions about the afterlife and can even sense anxiety with her advanced technology, The U.S. Sun has learned.

Through a camera in her eyes, the amazing bot called “Xoxe” (pronounced Zo-zie) can detect if anybody in her presence has committed any illegal activities.

Continue reading “Creepy ultrarealistic AI Xoxe sensed my anxiety as we discussed end of the world” »

About one-third of individuals suffering from depression are at risk for treatment resistance. Whereas inhaled 50% nitrous oxide has early antidepressant effects on individuals with treatment-resistant major depression (TRMD), adverse effects can occur at this concentration. In this phase 2 clinical trial, Nagele et al. studied the effects of a single 1-hour treatment with 25% nitrous oxide on depression symptoms in those with TRMD, finding that this lower concentration had comparable efficacy to 50% nitrous oxide over several weeks but was associated with significantly fewer adverse effects. These results highlight that lower concentrations of nitrous oxide may be a useful treatment for TRMD.

Twenty-five percent inhaled nitrous oxide improves symptoms of treatment-resistant major depression with fewer adverse effects than the 50% concentration.

A team of scientists from the University of Pittsburgh School of Medicine has found the missing puzzle piece in the mystery of how melanoma tumors control their mortality.

In a paper published in Science, they describe how they identified the specific genetic changes that allow tumors to grow rapidly while also preventing their own death. This discovery could have significant implications for the way melanoma is understood and treated by oncologists.

Summary: Roflumilast, a drug commonly prescribed for the treatment of COPD and asthma helps retrieve learning memories following a period of sleep deprivation in mice.

Source: University of Groningen.

Students sometimes pull an all-nighter to prepare for an exam. However, research has shown that sleep deprivation is bad for your memory.

A protein that helps lethal skin cancer spread through the body has been identified, according to scientists, offering new hope for cancer treatment. Protein LAP1 allows cancer cells to become more aggressive by letting them change the shape of their nucleus and migrate around the body. The most serious type of cancer cells, melanoma, was found to harbour LAP1 and high levels of it were linked to poor prognosis.

Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders — Dr. Richard K. Burt

Dr. Richard K. Burt MD (https://astemcelljourney.com/about/drrichardburt/) is a Fulbright Scholar, Professor of Medicine at Scripps Health Care, tenured retired Professor of Medicine at Northwestern University where he served as Chief of Immunotherapy and Autoimmune Diseases, and CEO of Genani Biotechnology.

Continue reading “Dr. Richard Burt MD — Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders” »

At CES 2023, the CEO of Moderna discussed mRNA technology.

The Covid-19 pandemic continues to be a terrible plight on the world. But if there’s any silver lining in what has happened, the deadly worldwide plague has brought about advancements in medicine created to fight it that may have transformational impacts well past the pandemic.

Continue reading “The mRNA vaccine technology may hold the key to developing personalized cancer treatments” »