Lifeboat Foundation

A therapeutic sponge the size of a pencil eraser boosted the body’s tumor-fighting response in mice and kept the cancer from returning.

Many solid tumors resist treatment in part by turning human biology against itself. Tumors surround themselves with extra white blood cells known as regulatory T cells, which call off the body’s natural defenses against the disease.

Strategies to treat cancer by deactivating these cells risk creating other serious problems. Since regulatory T cells play an important role in safeguarding healthy tissues, diminishing them throughout the body can lead to other immune cells mistakenly attacking these tissues and causing autoimmune conditions that damage the colon, liver, heart and other organs.

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Hackers constantly improve at penetrating cyber defenses to steal valuable documents. So some researchers propose using an artificial-intelligence algorithm to hopelessly confuse them, once they break-in, by hiding the real deal amid a mountain of convincing fakes. The algorithm, called Word Embedding–based Fake Online Repository Generation Engine (WE-FORGE), generates decoys of patents under development. But someday it could “create a lot of fake versions of every document that a company feels it needs to guard,” says its developer, Dartmouth College cybersecurity researcher V. S. Subrahmanian.

If hackers were after, say, the formula for a new drug, they would have to find the relevant needle in a haystack of fakes. This could mean checking each formula in detail—and perhaps investing in a few dead-end recipes. “The name of the game here is, ‘Make it harder,’” Subrahmanian explains. “‘Inflict pain on those stealing from you.’”

From the complexity of neural networks to basic biological functions and structures, the human brain only reluctantly reveals its secrets. Advances in neuro-imaging and molecular biology have only recently enabled scientists to study the living brain at level of detail not previously achievable, unlocking many of its mysteries. The latest discovery, described today in the journal Science, is a previously unknown component of brain anatomy that acts as both a protective barrier and platform from which immune cells monitor the brain for infection and inflammation.

The new study comes from the labs of Maiken Nedergaard, co-director of the Center for Translational Neuromedicine at University of Rochester and the University of Copenhagen and Kjeld Møllgård, M.D., a professor of neuroanatomy at the University of Copenhagen. Nedergaard and her colleagues have transformed our understanding of the fundamental mechanics of the human brain and made significant findings to the field of neuroscience, including detailing the many critical functions of previously overlooked cells in the brain called glia and the brain’s unique process of waste removal, which the lab named the glymphatic system.

“The discovery of a new anatomic structure that segregates and helps control the flow of cerebrospinal fluid (CSF) in and around the brain now provides us much greater appreciation of the sophisticated role that CSF plays not only in transporting and removing waste from the brain, but also in supporting its immune defenses,” said Nedergaard.

Due to cancer lots of people dies every year.

Popular Bengali actress Aindrila Sharma, 24, died on Sunday after suffering from multiple cardiac arrests. She was also a cancer survivor. Can cancer and its treatment affect heart? Here’s what experts have to say.

Investigators at Cedars-Sinai have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease.

The study is published today in the journal Nature Genetics.

“Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. In this study we applied a new technology called single-cell genomics, which allowed us to profile the many different cell types contributing to the disease,” said Kate Lawrenson, Ph.D., an associate professor in the Department of Obstetrics and Gynecology at Cedars-Sinai, and co-senior and corresponding author of the study.

Researchers have used fruit flies to decipher an unexplained connection between Alzheimer’s disease and a genetic variation, revealing that it causes neurons to die.

The findings from the Walter and Eliza Hall Institute (WEHI)-led team uncover a possible cause of neurodegeneration in the early stages of Alzheimer’s disease and open the door for the future development of new treatments for cognitive diseases.

The study, “An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration,” with collaborators from Australian National University, is published in Scientific Reports.

A variety of healthy eating patterns are linked to reduced risk of premature death, according to a new study led by Harvard T.H. Chan School of Public Health researchers. They found that participants who scored high on adherence to at least one of four healthy eating patterns were less likely to die during the study period from any cause and less likely to die from cardiovascular disease, cancer, or respiratory disease, compared with people with lower scores. The findings are consistent with the current Dietary Guidelines for America, which recommend multiple healthy eating patterns.

“The Dietary Guidelines for Americans are intended to provide science-based dietary advice that promotes good health and reduces major chronic diseases. Thus, it is critical to examine the associations between DGAs-recommended dietary patterns and long-term health outcomes, especially mortality,” said corresponding author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology and chair of the Department of Nutrition.

The study will be published online January 9, 2023, in JAMA Internal Medicine.

A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in test mice and the development of age-related macular degeneration. Kevin Mangum and Katherine Gallagher with the University of Michigan have published a Perspectives piece in the same journal issue outlining the research.

Age-related macular degeneration (AMD) in older people can lead to permanent blindness. Prior research has shown obesity plays a major role in its development. Other research has also shown that AMD is a neuroinflammatory condition. It is believed that the inflammation in the eyes is related to obesity, but the exact connection has not been identified. In this new effort, the researchers sought to find the connection by studying obesity and macular degeneration in mice.

The work involved feeding test mice a high-fat diet and studying the impact on adipose tissue macrophages (types of white blood cells that are part of the immune system). They found that obesity in mice led to epigenetic changes in the macrophages that resulted in an increase in expression of genes that incite an inflammatory response. They also found that the increased expression continued even after the test mice were put on a reduced diet that allowed them to return to their normal weight.

Needs work.

AN ultrarealistic AI robot has opinions about the afterlife and can even sense anxiety with her advanced technology, The U.S. Sun has learned.

Through a camera in her eyes, the amazing bot called “Xoxe” (pronounced Zo-zie) can detect if anybody in her presence has committed any illegal activities.

Continue reading “Creepy ultrarealistic AI Xoxe sensed my anxiety as we discussed end of the world” »