Magnesium Break Through 10% Discount https://bit.ly/3O5tPfu.
This video brought to you by BiOptimizers.
In this video Professor Sebastiano discusses the results that he and his team have had in rejuvenating human cells and how the process could be applied as well as their experience rejuvenating a muscle in an old mouse.
Cryo-electron microscopy by University of Alabama at Birmingham researchers has exposed the structure of a bacterial virus with unprecedented detail. This is the first structure of a virus able to infect Staphylococcus epidermidis, and high-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial infections.
Bacteriophages or “phages” is the terms used for viruses that infect bacteria. The UAB researchers, led by Terje Dokland, Ph.D., in collaboration with Asma Hatoum-Aslan, Ph.D., at the University of Illinois Urbana-Champaign, have described atomic models for all or part of 11 different structural proteins in phage Andhra. The study is published in Science Advances.
Andhra is a member of the picovirus group. Its host range is limited to S. epidermidis. This skin bacterium is mostly benign but also is a leading cause of infections of indwelling medical devices. “Picoviruses are rarely found in phage collections and remain understudied and underused for therapeutic applications,” said Hatoum-Aslan, a phage biologist at the University of Illinois.
Unity CEO Anirvan Ghosh, Ph.D./courtesy of Unity Biotechnology
Senolytic therapies are, at this point, as revolutionary as checkpoint inhibitors but with broader effectiveness. This approach delays the onset of diseases of aging by removing senescent cells from the body, thus enabling people to remain healthier longer or to regain some degree of function lost to disease.
Senolytics is a new field and most of the research is still in academic centers – most notably, the Mayo Clinic. Approval of any therapeutics is years – perhaps even a decade – away.
During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides. Ceramides, known for their use in skin care products, are sphingolipids, a class of fat molecules that are not used to produce energy but rather perform different tasks in the cell.
The researchers found that, in aging, there is an overload of the protein SPT and others, all of which are needed to convert fatty acids and amino acids to ceramides. “The sphingolipids and ceramides are complex yet very interesting fat class, and there is high potential to further study their role in aging, as they perform many diverse functions,” says Dr. Pirkka-Pekka Laurila, a medical doctor and the lead author of the study.
Next, the scientists wanted to see whether reducing ceramide overload could prevent age-related decline in muscle function. They treated old mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used adeno-associated viruses to block ceramide synthesis specifically in muscle. The ceramide blockers prevented loss of muscle mass during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination.
Summary: Researchers identified two FDA-approved drugs that can mitigate or even eliminate the brain fog associated with COVID-19 infection.
Source: Yale.
Individuals with long COVID, sometimes referred to as “long-haulers,” experience symptoms that may persist for weeks, months, or even years after their acute viral infection.
A recent study identified a non-insulin-related protein that can activate the human insulin receptor, which could lead to the development of an insulin-mimicking oral pill and replace the need for daily injections to treat diabetes.
Many investors are jumping to inject money into the startup.
Bill Gates and Jeff Bezos-backed foundations (Gates Frontier and Bezos Expeditions) have joined other companies in investing $75 million in Synchron, the endovascular brain-computer interface (BCI) company, according to a press release by the organization published on Thursday. This is a Series C financing round led by ARCH Venture Partners that brings the total amount raised since inception to $145 million.
Many investors on board.
Continue reading “Gates and Bezos back Neuralink-competitor Synchron in a new funding” »
The study shows that machine-learning models can help predict COVID-19 infections.
Researchers have discovered a new way to predict which features are most useful in determining test results for COVID-19. The research team, from Florida Atlantic University’s (FAU) College of Engineering and Computer Science in the U.S., used AI to predict positive or negative COVID-19 test results.
The most common techniques currently used to detect COVID-19 are blood tests, also called serology tests, and molecular tests. Since the two assessments use different methods, they vary substantially.
Materials scientists at UNSW Sydney have shown that human pluripotent stem cells in a lab can initiate a process resembling the gastrulation phase—where cells begin differentiating into new cell types—much earlier than occurs in mother nature.
For an embryo developing in the womb, gastrulation occurs at day 14. But in a dish in a lab at UNSW’s Kensington campus, Scientia Associate Professor Kris Kilian oversaw an experiment where a gastrulation-like event was triggered within two days of culturing human stem cells in a unique biomaterial that, as it turned out, set the conditions to mimic this stage of embryo development.
“Gastrulation is the key step that leads to the human body plan,” says A/Prof. Kilian.
Vitamin D plays an important role in the regulation of calcium and phosphorus absorption by the organism. It also helps keep the brain and immune system working. Researchers at the Federal University of São Carlos (UFSCar) in Brazil and University College London (UCL) in the United Kingdom have now shown that vitamin D supplementation reduces the risk of dynapenia in older people by 78%.
Dynapenia is an age-associated loss of muscle strength. It can be partially explained by muscle atrophy and is a major risk factor for physical incapacity later in life. People with dynapenia are more likely to fall, need to go to hospital, be prematurely institutionalized, and die.
An article on the study is published in the journal Calcified Tissue International and Musculoskeletal Research. The study was supported by FAPESP.
