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Category: biotech/medical – Page 734

Brain Cells That Enhance Memory Focus and Storage Identified

Summary: Researchers uncovered how certain brain cells enhance our ability to maintain and focus on short-term memories. Their study highlights a new type of neuron, dubbed PAC neurons, which coordinate the activity of memory-specific neurons without storing any information themselves.

These findings were derived from the brain activity recordings of epilepsy patients during memory tasks, providing novel insights into how working memory functions. Understanding these mechanisms may lead to improved treatments for disorders like Alzheimer’s and ADHD, where such cognitive functions are impaired.

Global study reveals health impacts of airborne trace elements

As anyone with seasonal allergies knows, unseen airborne particles can really wreck a person’s day. Like the tree pollen that might be plaguing you this spring, small concentrations of trace elements in the air can have significant negative impacts on human health. However, unlike pollen counts and other allergy indices, which are carefully tracked and widely available, limited knowledge exists about the ambient concentrations of cancer-causing trace elements like lead and arsenic in urban areas of developing countries.

SPARDA: A Programmable Nucleic Acid Targeting Technology Like CRISPR

An innovative programmable tool for targeting nucleic acids has been created, utilizing a prokaryotic immune defense system—and it is not CRISPR-Cas. Russian Academy of Sciences researchers have successfully re-engineered prokaryotic Argonautes (pAgos) to utilize RNA guides for locating nucleic acid sequences. These systems have been modified to form a complex with effector nucleases.

The researchers employed a two-component system known as SPARDA (short prokaryotic Argonaute, DNase, and RNase-associated) to effectively identify DNA sequences with a notable level of sensitivity and induce collateral nuclease activity. SPARDA and other concise pAgos systems that encode diverse effectors have the potential to offer a novel programmable tool for the field of biotechnology.

The research article “DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity” was published in Nature Microbiology.

COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

A recent USC study provides new information about why SARS-CoV-2, the virus behind the COVID-19 pandemic, may elicit mild symptoms at first but then, for a subset of patients, turn potentially fatal a week or so after infection. The researchers showed that distinct stages of illness correspond with the coronavirus acting differently in two different populations of cells.

The study, published in Nature Cell Biology, may provide a roadmap for addressing cytokine storms and other excessive immune reactions that drive serious COVID-19.

The team found that when SARS-CoV-2 infects its first-phase targets, cells in the lining of the lung, two viral proteins circulate within those cells—one that works to activate the immune system and a second that, paradoxically, blocks that signal, resulting in little or no inflammation.

Groundbreaking: Japanese scientists develop a technique to connect brain cells grown in the lab

I found this on NewsBreak.

According to reports, Japanese scientists have devised a technique for connecting lab-grown brain-mimicking tissue„ like how circuits in our brain work.

Researchers at the University of Tokyo released a study in Nature Communications journal that looked into making a seemingly impossible idea a reality.

The scientists discovered a new approach to establishing physiological connections between lab-grown neuronal organoids. These organoids are experimental model tissues created by growing human stem cells into 3D-developed brain-like structures.

Discover the Key to Happiness and Fulfillment with Harvard Psychiatrist’s Advice

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The Next Frontier for Brain Implants Is Artificial Vision

In 2021, he heard about a trial of a visual prosthesis at Illinois Institute of Technology in Chicago. Researchers cautioned that the device was experimental and he shouldn’t expect to regain the level of vision he had before. Still, he was intrigued enough to sign up. Thanks to the chips in his brain, Bussard now has very limited artificial vision—what he describes as “blips on a radar screen.” With the implant, he can perceive people and objects represented in white and iridescent dots.

Bussard is one of a small number of blind individuals around the world who have risked brain surgery to get a visual prosthesis. In Spain, researchers at Miguel Hernández University have implanted four people with a similar system. The trials are the culmination of decades of research.

There’s interest from industry, too. California-based Cortigent is developing the Orion, which has been implanted in six volunteers. Elon Musk’s Neuralink is also working on a brain implant for vision. In an X post in March, Musk said Neuralink’s device, called Blindsight, is “already working in monkeys.” He added: “Resolution will be low at first, like early Nintendo graphics, but ultimately may exceed normal human vision.”

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