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Category: biotech/medical – Page 648

21 Best Longevity Experts and Influencers on Twitter/X

We’ve updated our list of the best longevity experts on Twitter/X and added 8 new accounts, including Dr. Morgan Levine, Dr. Brad Stanfield, and the research journal Nature Aging!

Best known for his popular longevity YouTube channel, Stanfield is a medical doctor with an interest in longevity science. Like some other folks on this list of longevity influencers, Stanfield can be a bit iconoclastic, challenging orthodoxy on things like resveratrol and fisetin.

Just like in his well-sourced videos, Stanfield’s Twitter feed is heavy with links to research papers and studies on longevity-related topics, from recent mouse studies out of the Interventions Testing Program, to threads on diet based on new trials. The downside is in his Twitter feed you don’t get to hear that sweet Kiwi accent you get from his videos.

Followers: 24,000

Founder and CEO of AI drug discovery Insilico Medicine (which has raised over $400 million under his leadership), Alex Zhavoronkov seems to be everywhere in longevity circles. From serving on the board of Peter Diamandis’s X-Prize Foundation (which recently announced its longevity X-Prize), to founding biological age testing company Deep Longevity, to somehow having the time to publish over 170 peer-reviewed studies.

Prescription guide

To show one of the advantages of being a cyborg, I typed my old prescription into ZEISS Optical Inserts which are for use with the Apple Vision Pro and it said “We are really sorry, but your prescription values go beyond the available range.”

But now that I’m a cyborg with artificial lenses, any optical inserts that I might need are very common and available.

Oh, I experimented a little and it looks like they can’t make lenses for −9.75 diopters or worse. My left-eye used to be −17.25!

We need your eyeglass prescription to create your ZEISS Optical Inserts – Prescription (sometimes also called distance prescription). This is why we ask you to upload it.

Contact lens prescriptions or ones for task-specific uses (office or computer glasses, near reading glasses) don’t qualify.

Engineered Immune Cells Improves Metabolic Function

Immunotherapy has rapidly advanced the field of medicine and has saved countless lives. The approach is much different than using an external chemical, such as in the case of chemotherapy. Immunotherapy leverages the body’s own immune system to recognize and attack foreign pathogens, specifically cancer. While there are many versions of immunotherapy, one rising star among them is known as Chimeric Antigen Receptor (CAR) T cell therapy. This therapy (usually) takes a patient’s own cells in the blood to generate engineered immune or T cells to fight the tumor. T cells are a critical immune cell population responsible for killing or lysing infected cells. In the case of CAR T cell therapy, the T cells from the patient are engineered to recognize receptors on the tumor. The CAR T-cells are then triggered to release different proteins and lyse the tumor cells. This type of therapy has revolutionized the way we treat patients with hematopoietic malignancies or blood cancers.

Study reveals mechanism that aggravates tuberculosis and reduces survival rates

CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections. However, an article published in the journal Cell Reports shows that an imbalance in the volumes of these defense cells in different parts of the lung in response to infection can do more harm than good.

The study described in the article involved infecting mice with hypervirulent tuberculosis and influenza. The authors concluded that an “ideal amount” of CD4+ T cells in the lungs was required for a cure.

This finding opens up perspectives for therapeutic interventions aimed at combating diseases that attack the lungs while not affecting the ability of the adaptive immune system to fight off infection. Even relatively small numbers of CD4+ T cells in the lungs proved sufficient to afford protection against tuberculosis, for example.

Heart-to-heart connection: Collaboration brings a breakthrough science exhibit to life

One of the country’s best-known science museums, San Francisco’s Exploratorium, is located less than three miles north of Gladstone Institutes—proximity that has resulted in creative, high-science collaborations like the permanent exhibit featured in the latest issue of Stem Cell Reports.

Among the museum’s most popular exhibits, “Give Heart Cells A Beat” opens a rare window into the microscopic world of the beating human heart, using technology and materials made possible through Gladstone’s science and expertise. With the exhibit, the team created the first interactive museum experience that allows the public to interact directly with living cardiomyocytes.

“It’s like having a lens into yourself because these same types of cells are within us—it’s an incredible experience for our visitors,” says Kristina Yu, Ph.D., senior director of science R&D for the Exploratorium.

Scientists code ChatGPT to design new medicine

To create the breakthrough model, researchers integrated two cutting-edge #AI techniques for the first time in the fields of #bioinformatics and #Cheminformatics : the well-known “Encoder-Decoder Transformer architecture” and “Reinforcement Learning via Monte Carlo Tree Search” (RL-MCTS).

Generative artificial intelligence platforms, from ChatGPT to Midjourney, grabbed headlines in 2023. But GenAI can do more than create collaged images and help write emails—it can also design new drugs to treat disease.

Today, scientists use advanced technology to design new synthetic drug compounds with the right properties and characteristics, also known as “de novo drug design.” However, current methods can be labor-, time-, and cost-intensive.

Inspired by ChatGPT’s popularity and wondering if this approach could speed up the drug design process, scientists in the Schmid College of Science and Technology at Chapman University in Orange, California, decided to create their own GenAI model, detailed in a new paper, “De Novo Drug Design using Transformer-based Machine Translation and Reinforcement Learning of Adaptive Monte-Carlo Tree Search,” appearing in the journal Pharmaceuticals.

Quantum materials: A new state of matter with chiral properties

An international research group has discovered a new state of matter characterized by the existence of a quantum phenomenon called chiral current. These currents are generated on an atomic scale by a cooperative movement of electrons, unlike conventional magnetic materials whose properties originate from the quantum characteristic of an electron known as spin and their ordering in the crystal.

Chirality is a property of extreme importance in science, for example, it is fundamental also to understand DNA. In the discovered, the chirality of the currents was detected by studying the interaction between light and matter, in which a suitably polarized photon can emit an electron from the surface of the material with a well-defined spin state.

The discovery, published in Nature, significantly enriches our knowledge of quantum materials in the search for chiral quantum phases and on the phenomena that occur at the surface of materials.

How lung cancer hijacks immune cell metabolism to fuel its own growth

Lung adenocarcinoma is the most common lung cancer and the cause of most cancer-related deaths in the United States. There are several ways lung adenocarcinoma can arise, one of which is a mutation in a protein called EGFR (epidermal growth factor receptor). Non-mutated EGFR helps cells grow in response to injury, but mutated EGFR promotes out-of-control growth that can turn into cancer.

Modern immunotherapies don’t work against EGFR-driven lung adenocarcinoma, and while some drugs exist to treat the cancer, patients typically develop a resistance to them within just a few years. This gap in the treatment tool chest inspired Salk Institute researchers to probe for weak spots in the cancer’s growth pathway.

The team discovered that EGFR-driven lung adenocarcinoma hijacks a specialized population of lung-resident immune cells called macrophages, which are designed to dispose of diseased and damaged cells, as well as maintain a delicate balance of protective lipids (fats) around lung alveoli, which are essential for breathing.

Smooth Control of Active Matter

A theoretical study finds that the most energy-efficient way to control an active-matter system is to drive it at finite speed—unlike passive-matter systems.

The control of active matter, a class of systems in which each constituent constantly converts energy into directed motion, holds great potential for applications ranging from the targeted delivery of drugs to the creation of smart materials. Using an active-matter system to achieve a particular goal requires that one can efficiently drive it from one state to another. However, active matter’s intrinsic nonequilibrium condition presents a major challenge for theoretical treatments, meaning the most efficient way of driving a system is often difficult to predict. Now Luke Davis at the University of Luxembourg and colleagues have introduced a general framework to determine thermodynamically optimal protocols to drive active systems between different states in a way that minimizes the associated heat dissipation [1].