Lifeboat Foundation

Circa 2019 face_with_colon_three

By Tyler Benster.

Neuroscientists have a dizzying array of methods to listen in on hundreds or even thousands of neurons in the brain and have even developed tools to manipulate the activity of individual cells. Will this unprecedented access to the brain allow us to finally crack the mystery of how it works? In 2017, Jonas and Kording published a controversial research article, “Could a Neuroscientist Understand a Microprocessor?” that argues maybe not. To make their point, the authors turn to their “model organism” of choice: a MOS 6502 processor as popularized by the Apple I, Commodore 64, and Atari Video Game System. Jonas and Kording argue that for an electrical engineer, a satisfying description of the processor would break it into modules, like an adder or subtractor, and submodules, like the transistor, to form a hierarchy of information processing. They suggest that, while popular methods from neuroscience might reveal interesting structure in the activity of the brain, researchers often use techniques that would fail to reveal a hierarchy of information processing if applied to the (presumably much simpler) computer processor.

Continue reading “Can we reverse engineer the brain like a computer?” »

The global dairy industry is changing. Among the disruptions is competition from food alternatives not produced using animals – including potential challenges posed by synthetic milk.

Synthetic milk does not require cows or other animals. It can have the same biochemical make up as animal milk, but is grown using an emerging biotechnology technique know as “precision fermentation” that produces biomass cultured from cells.

More than 80 percent of the world’s population regularly consume dairy products. There have been increasing calls to move beyond animal-based food systems to more sustainable forms of food production.

According to a new meta-analysis, gene variants associated with a person’s blood type may be linked to their risk of early stroke.

“Non-O blood types have previously been linked to a risk of early stroke, but the findings of our meta-analysis showed a stronger link between these blood types with early stroke compared to late stroke, and in linking risk mostly to blood type A,” said study author Braxton D. Mitchell, PhD, MPH, of University of Maryland School of Medicine in Baltimore. “Specifically, our meta-analysis suggests that gene variants tied to blood types A and O represent nearly all of those genetically linked with early stroke. People with these gene variants may be more likely to develop blood clots, which can lead to stroke.”

48 studies on genetics and ischemic stroke from North America, Europe, and Asia were reviewed in the meta-analysis. 16,927 people with stroke and 576,353 people who did not have a stroke were included in the studies. Of those with stroke, 5,825 people had early onset stroke and 9,269 people had late onset stroke. Early onset stroke was defined as an ischemic stroke occurring before age 60 and late-onset stroke was older than 60 years old.

A team of researchers from Stanford University has constructed the first synthetic microbiome model, built entirely from scratch and encompassing more than 100 different bacterial species. It’s hoped the achievement will revolutionize gut microbiome research by offering scientists a consistent working model for future experiments.

Trillions of microbes live inside our guts. Perhaps one of the most significant discoveries in medical science over recent decades has been how deeply these microbes influence our general health. From affecting how well drugs we consume work, to modulating our immune systems, the gut microbiome plays a powerful role in all aspects of our health.

It’s also mind-bendingly complex. No two people share exactly the same gut microbiome composition. And while researchers frequently home in on ways particular bacteria influence metabolic mechanisms, it has been difficult to translate these findings into actual clinical therapies for humans.

A treatment developed by a Japanese doctor and his team is helping women with premature menopause to give birth with their own eggs. Premature menopause is triggered by a malfunctioning of the ovaries and affects even those in their teens. The treatment involves activating dormant primordial follicles. We focus on the method, which has been described by TIME Magazine as a global breakthrough. We also introduce herbs that can alleviate symptoms such as those of menopause.

An alzheimer’s-proof brain: a groundbreaking case.

In a groundbreaking case researchers from the Massachusetts General Hospital have discovered a gene variant that seems to have disrupted the pathology of Tau Protein. The case of Aliria Rosa Piedrahita de Villegas.

Continue reading “Groundbreaking Alzheimer’s Case: Gene APOE3” »

Bionic technology is removing physical barriers faced by disabled people while raising profound questions of what it is to be human. From DIY prosthetics realised through 3D printing technology to customised AI-driven limbs, science is at the forefront of many life-enhancing innovations.

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Continue reading “Beyond bionics: how the future of prosthetics is redefining humanity” »

An astrophysicist at the University of Bologna and a neurosurgeon at the University of Verona compared the network of neuronal cells in the human brain with the cosmic network of galaxies… and surprising similarities emerged.

In their paper published in Frontiers in Physics, Franco Vazza (astrophysicist at the University of Bologna) and Alberto Feletti (neurosurgeon at the University of Verona) investigated the similarities between two of the most challenging and complex systems in nature: the cosmic network of galaxies and the network of neuronal cells in the human brain.

Despite the substantial difference in scale between the two networks (more than 27 orders of magnitude), their quantitative analysis, which sits at the crossroads of cosmology and neurosurgery, suggests that diverse physical processes can build structures characterized by similar levels of complexity and self-organization.

Researchers have created a way for artificial neuronal networks to communicate with biological neuronal networks. The new system converts artificial electrical spiking signals to a visual pattern than is then used to entrain the real neurons via optogenetic stimulation of the network. This advance will be important for future neuroprosthetic devices that replace damages neurons with artificial neuronal circuitry.

A prosthesis is an artificial device that replaces an injured or missing part of the body. You can easily imagine a stereotypical pirate with a wooden leg or Luke Skywalker’s famous robotic hand. Less dramatically, think of old-school prosthetics like glasses and contact lenses that replace the natural lenses in our eyes. Now try to imagine a prosthesis that replaces part of a damaged brain. What could artificial brain matter be like? How would it even work?

Creating neuroprosthetic technology is the goal of an international team led by by the Ikerbasque Researcher Paolo Bonifazi from Biocruces Health Research Institute (Bilbao, Spain), and Timothée Levi from Institute of Industrial Science, The University of Tokyo and from IMS lab, University of Bordeaux. Although several types of artificial neurons have been developed, none have been truly practical for neuroprostheses. One of the biggest problems is that neurons in the brain communicate very precisely, but electrical output from the typical electrical neural network is unable to target specific neurons. To overcome this problem, the team converted the electrical signals to light. As Levi explains, “advances in optogenetic technology allowed us to precisely target neurons in a very small area of our biological neuronal network.”