SCIENTISTS are developing a DNA test to tell if a man’s prostate cancer will come back.
Patients who are at genetic risk of tumour cells flying under the radar and surviving radiotherapy could get extra treatment to make sure they are all wiped out.
Category: biotech/medical – Page 543
Challenges in Producing and Analyzing Organoids
Recent advancements in our comprehension of human health and disease have been propelled by pioneering research utilizing in vitro 3D cell culture models, including both single-cell spheroids and multicellular organoids.
The refinement of these 3D cell culture models hinges on the capacity to visualize, measure, and track their development and expansion over time. Nonetheless, the methods employed to evaluate and scrutinize these intricate cell models are not without their challenges.
This video explores the challenges associated with characterizing organoids and introduces some solutions to these challenges.
Learn more about our solutions: https://www.sartorius.com/en/applicat…
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Enhanced CRISPR method enables stable insertion of large genes into the DNA of higher plants
Scientists at the Leibniz Institute of Plant Biochemistry (IPB) have succeeded for the first time in stably and precisely inserting large gene segments into the DNA of higher plants very efficiently. To do this, they optimized the gene-editing method CRISPR/Cas, commonly known as “genetic scissors.”
The improved CRISPR method offers great opportunities for the targeted modification of genes in higher plants, both for breeding and research. The study, led by Prof. Alain Tissier and Dr. Tom Schreiber, has been published in Molecular Plant.
CRISPR/Cas is a method with enormous potential for the targeted modification of individual genes. However, this does not apply to all kinds of genetic modifications that breeders and scientists have on their wish lists. While the genetic scissors are ideal for knocking out genes, i.e., switching off or removing existing genes, they do not work well for precisely inserting genes or replacing gene segments. To date, genetic scissors have been too inefficient and therefore of little use for the targeted insertion of genes into the DNA of higher plants.
Nasal Spray Safely Treats Recurrent Abnormal Heart Rhythms, Clinical trial suggests
A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study, published March 25 in the Journal of the American College of Cardiology, provides real-world evidence that a wide range of patients can safely and effectively use the experimental drug, called etripamil, to treat recurrent paroxysmal supraventricular tachycardia (PSVT) episodes at home, potentially sparing them the need for repeated hospital trips for more invasive treatments.
The study is the latest in a series of studies by lead author Dr. James Ip, professor of clinical medicine at Weill Cornell Medicine and a cardiologist at New York-Presbyterian/Weill Cornell Medical Center, and colleagues to demonstrate the potential of nasal spray calcium-channel blocker etripamil as an at-home treatment PSVT.
Dr. Ip received compensation as a steering committee member for Milestone Pharmaceuticals, the maker of etripamil and sponsor of the trial.
Study identifies driver of liver cancer that could be target for treatment
In a new study, a Yale Pathology team has identified a possible therapeutic target for treating obesity-induced liver cancer.
Researchers say inhibiting a molecule called fatty acid binding protein 5 (FABP5) could block tumor progression in many cases:
Inhibiting a certain protein in mice reduced obesity-induced liver tumor development, Yale researchers found. It could reveal a future treatment route.
The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing
Abstract. In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges.