The ability to distinguish between left-and right-handed molecules using mass spectrometry could streamline a laborious part of drug discovery.
Category: biotech/medical – Page 536
A fledgling startup founded by one of OpenAI’s first engineering hires is looking to “redefine manufacturing,” with AI-powered factories for creating bespoke precision parts.
Daedalus, as the company is called, is based in the southwestern German city of Karlsruhe, where its solo factory is currently housed. Here, Daedalus takes orders from industries such as medical devices, aerospace, defense, and semiconductors, each requiring unique components for their products. For example, a pharmaceutical company might require a customized metal casing for a valve used in the production of a particular medicine.
As it looks to ramp up operations with a view toward opening additional factories in its domestic market, Daedalus today announced it has raised $21 million in a Series A round of funding led by Nokia-funded NGP Capital, with participation from existing investors Khosla Ventures and Addition.
Urokinase therapy improves diabetic foot ulcer healing and decreases CV events in diabetes patients suggests a new study published in the BMJ Open Diabetes Research & Care.
Diabetic foot ulcer (DFU) is a disabling complication of diabetes mellitus. Here, we attempted to assess whether long-term intrafemoral artery infusion of low-dose urokinase therapy improved Diabetic foot ulcers and decreased cardiovascular events in patients with Diabetic foot ulcers were randomized to continuous intrafemoral thrombolysis or conventional therapy groups. The continuous intrafemoral thrombolysis group received continuous intrafemoral urokinase injection for 7 days, and conventional therapy just received wound debridement and dressing change. Then, a follow-up of average 6.5 years was performed. Results: Compared with conventional therapy, at the first 1 month of intervention stage, the ulcers achieved a significant improvement in continuous intrafemoral thrombolysis group including a complete closure (72.4% vs 17.5%), an improved ulcer (27.6% vs 25.8%), unchanged or impaired ulcer (0% vs 56.7%). During the 6.
A new study shows congenital heart disease can be induced by pregestational diabetes using advanced human heart organoids.
A CRISPR treatment for hereditary angioedema significantly reduced swelling attacks in its first human trial.
The nanospace confinement of a magnetic nanoparticle within a porous cage, coupled with an encodable DNA clutch interface, enables a remotely powered and controlled rotary nanomotor that is autoresponsive to its microenvironment.
Chemists at RIKEN have developed a method for making synthetic derivatives of the natural dye indigo that doesn’t require harsh conditions. This discovery could inspire advances in electronic devices, including light-responsive gadgets and stretchy biomedical sensors.
Semiconductors based on organic molecules are attracting much interest because—unlike conventional rigid semiconductors based on silicon—they could be flexible, ductile and lightweight, opening up new possibilities for designing semiconductor devices.
Organic molecules also have the advantage of realizing a broad range of structures. “Organic semiconductors have flexibility in molecular design, enabling them to adopt new functionalities,” says Keisuke Tajima of the RIKEN Center for Emergent Matter Science, who led the research.
A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing. The new combination of materials, created by a team led by researchers at Penn State, could also provide a platform to explore physical behaviors similar to those of mysterious, theoretical particles known as chiral Majoranas, which could be another promising component for quantum computing.
The new study appears in the journal Science. The work describes how the researchers combined the two magnetic materials in what they called a critical step toward realizing the emergent interfacial superconductivity, which they are currently working toward.
Superconductors—materials with no electrical resistance —are widely used in digital circuits, the powerful magnets in magnetic resonance imaging (MRI) and particle accelerators, and other technology where maximizing the flow of electricity is crucial.
From Alzheimer’s discoveries to animal organ transplants, new breakthroughs are improving and extending lives.
In a new Nature Communications study, researchers have explored the construction of genetic circuits on single DNA molecules, demonstrating localized protein synthesis as a guiding principle for dissipative nanodevices, offering insights into artificial cell design and nanobiotechnology applications.
The term “genetic circuit” is a metaphorical description of the complex network of genetic elements (such as genes, promoters, and regulatory proteins) within a cell that interact to control gene expression and cellular functions.
In the realm of artificial cell design, scientists aim to replicate and engineer these genetic circuits to create functional, self-contained units. These circuits act as the molecular machinery responsible for orchestrating cellular processes by precisely regulating the production of proteins and other molecules.