Firefighters show higher rates of glioma-linked SBS42 mutational signatures associated with haloalkane exposure, suggesting occupational risk. The study highlights a clear link between firefighting, chemical exposure, and brain cancer mutations.
Category: biotech/medical – Page 510
The Power of DNA: Unlocking the Secrets of Genetics, Medicine, and the Future of Human Health
DNA holds the key to understanding life itself… From genetics and the human genome to gene editing, it shapes our health, evolution, and future… Discover how CRISPR, forensic science, and genetic engineering are transforming medicine… Explore the mysteries of ancient DNA, the role of the microbiome, and the promise of gene therapy… Personalized medicine is revolutionizing healthcare, allowing treatments tailored to our genetic code… Learn how hereditary diseases are being decoded and cured through biotechnology and DNA sequencing… The future of medicine depends on genetic research, but genetic ethics raise profound questions… The genome project has paved the way for DNA fingerprinting, cloning, and synthetic biology… With genetic modification, we are reshaping evolution itself… Will genetic testing lead to designer babies or eliminate genetic disorders? As gene therapy advancements push the limits of precision medicine, are we ready for these medical breakthroughs and DNA discoveries?
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#DNABreakthroughs #GeneticsRevolution #HumanGenome #GeneTherapy #FutureOfMedicine.
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Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice.
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In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis. Partial reprogramming with AAV2-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.
With $200M in seed funding, Flagship-backed Lila Sciences touts ambitious AI vision
Biotech incubator Flagship Pioneering has uncorked its latest company. Lila Sciences is looking to use $200 million in seed funding to develop new advanced artificial intelligence that can power fully autonomous research labs, according to a March 10 press release.
In addition to Flagship, the financing comes from General Catalyst, March Capital, the ARK Venture Fund, Altitude Life Science Ventures, Blue Horizon Advisors, the State of Michigan Retirement System, Modi Ventures and a wholly owned subsidiary of the Abu Dhabi Investment Authority, according to the release.
Scientists make ‘life-changing’ discovery over protein linked with Parkinson’s
Scientists have made a potentially “life-changing” discovery that could pave the way for new drugs to treat Parkinson’s disease.
Experts have known for several decades that the PINK1 protein is directly linked to Parkinson’s disease – the fastest growing neurodegenerative condition in the world.
Until now, no one has seen what human PINK1 looks like, how PINK1 attaches to the surface of damaged mitochondria inside of cells, or how it is activated.
Researchers develop innovative method for secure operations on encrypted data without decryption
A hospital that wants to use a cloud computing service to perform artificial intelligence data analysis on sensitive patient records needs a guarantee those data will remain private during computation. Homomorphic encryption is a special type of security scheme that can provide this assurance.
The technique encrypts data in a way that anyone can perform computations without decrypting the data, preventing others from learning anything about underlying patient records. However, there are only a few ways to achieve homomorphic encryption, and they are so computationally intensive that it is often infeasible to deploy them in the real world.
MIT researchers have developed a new theoretical approach to building homomorphic encryption schemes that is simple and relies on computationally lightweight cryptographic tools. Their technique combines two tools so they become more powerful than either would be on its own. The researchers leverage this to construct a “somewhat homomorphic” encryption scheme—that is, it enables users to perform a limited number of operations on encrypted data without decrypting it, as opposed to fully homomorphic encryption that can allow more complex computations.
New capabilities in DNA nanostructure self-assembly eliminate need for extreme heating and controlled cooling
University at Albany researchers at the RNA Institute are pioneering new methods for designing and assembling DNA nanostructures, enhancing their potential for real-world applications in medicine, materials science and data storage.
Their latest findings demonstrate a novel ability to assemble these structures without the need for extreme heat and controlled cooling. They also demonstrate successful assembly of unconventional “buffer” substances including nickel. These developments, published in the journal Science Advances, unlock new possibilities in DNA nanotechnology.
DNA is most commonly recognized for its role in storing genetic information. Composed of base pairs that can easily be manipulated, DNA is also an excellent material for constructing nanoscale objects. By “programming” the base pairs that make up DNA molecules, scientists can create precise structures as small as a few nanometers that can be engineered into shapes with intricate architectures.
Are Room Temperature Superconductors IMPOSSIBLE?
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Superconductive materials seem miraculous. Their resistanceless flow of electricity has been exploited in some powerful ways—from super-strong magnets used in MRIs, particle accelerators and fusion plants. And then there’s, their bizarre ability to levitate in magnetic fields. But the broader use of superconductors is limited because they need to be cooled to extremely low temperatures to work. But what if we could produce superconductivity at room temperature? It would change the world.
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Trial Repairs Irreversible Corneal Damage With Stem Cell Therapy
Two of the participants met the definition of partial success at 12 and 18 months, and the overall success of CALEC was 93% at 12 months and 92% at 18 months. Three participants received a second corneal CALEC transplant, of which one experienced complete success by the end check-up visit of the study.
Additional analysis of the impact of CALEC on vision showed varying levels of improvement of visual acuity in all 14 of the participants. The corneal procedure displayed a high safety profile with no adverse events occurring. However, one participant had a bacterial infection eight months after transplant due to chronic contact lens use. Any other adverse events were minor and were resolved quickly.
The CALEC trial is the first human study of a stem cell therapy to be funded by the National Eye Institute (NEI) branch of the NIH. However, the CALEC procedure remains an experimental procedure and it is not offered at Mass Eye and Ear or at any other hospital in America. Mass General Brigham’s Gene and Cell Therapy Institute will be conducting additional randomized-control design studies including a larger number of participants at multiple centers, with longer follow-ups before this treatment will be submitted for federal approval.