The Tune Therapeutics results are the first published data showing successful CRISPR epigenome editing in non-human primates.
One way to put dentists out of the drilling and filling business is to find a way to re-establish and stimulate something our bodies do when our teeth first form. Stem cell researchers at the University of Washington in Seattle may have figured out a potential treatment to repair damaged teeth and regenerate those we lose.
Hai Zhang, a professor of restorative dentistry at the University, along with several colleagues has found a way to generate ameloblasts. What are they? Ameloblasts are one of two cells that exist in human embryos responsible for the formation of our teeth. The other cells are called odontoblasts—the former secrete enamel, the latter dentin.
The process of tooth development is called odontogenesis. The two cells mentioned above are critical to tooth formation. Enamel keeps our teeth surfaces hard and strong throughout our lifetimes. Mineralization of teeth begins early in embryonic development. Dentin precedes enamel production, both critical to giving us a healthy set of choppers.
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SINGAPORE, 14 April 2023 – A preclinical study using stem cells to produce progenitor photoreceptor cells—light-detecting cells found in the eye—and then transplanting these into experimental models of damaged retinas has resulted in significant vision recovery. This finding, by scientists at Duke-NUS Medical School, the Singapore Eye Research Institute and the Karolinska Institute in Sweden, marks a first step towards potentially restoring vision in eye diseases characterised by photoreceptor loss.
Research reveals a promising stem cell approach to correct photoreceptor cell degeneration, which underlies several forms of visual decline and blindness.
Franzova and Shen et al. report that unresponsive patients with cognitive motor dissociation have intact ascending arousal pathways, preserved thalamocortical f.
An experimental procedure was found to improve the vision of patients whose eyes were damaged, according to a new study. NBC News’ Kristen Dahlgren has more on the procedure, which uses stem cells to restore the cornea.
People don’t go into Michael Angelo’s field to be cool.
“Pathology is like the chess club of medicine,” said Angelo MD, PhD, an assistant professor of pathology at the Stanford School of Medicine. You don’t join for status — you join because you love it, he said.
Still, Angelo got the idea for a pretty cool technology when he was a young pathology resident studying the origins and trajectory of disease.
From marigolds to human babies, most complex organisms start as a single-celled embryo. In his new book, Ben Stanger explores what our humble origins could teach us about health and disease.
By Clare Wilson
AMOLF researchers discovered that stem cells first specialize into a functional cell and then move to their proper location—rather than the other way around.
Researchers at AMOLF, Amsterdam, and the Hubrecht institute, Utrecht, revealed a new model to show how stem cells specialize into functional cells. They found that their position in the organ is not as important as current models claim. Rather, stem cells choose their identity first and only then move to their appropriate position.
These discoveries were made using intestinal organoids and the new TypeTracker technique, which can now be used to understand other organs at the cellular level and the effects of mutations and medications. The findings were published on August 18 in the journal Science Advances.
The research, published in Proceedings of the National Academy of Sciences, used a genetic approach to fix deafness in mice with a defective Spns2 gene, restoring their hearing abilities in low and middle frequency ranges. Researchers say this proof-of-concept study suggests that hearing impairment resulting from reduced gene activity may be reversible.
Over half of adults in their 70s experience significant hearing loss. Impaired hearing is associated with an increased likelihood of experiencing depression and cognitive decline, as well as being a major predictor of dementia. While hearing aids and cochlear implants may be useful, they do not restore normal hearing function, and neither do they halt disease progression in the ear. There is a significant unmet need for medical approaches that slow down or reverse hearing loss.
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has successfully reversed hearing loss in mice.
Continue reading “Researchers reverse hearing loss in mice” »
