A cyclophosphamide-based regimen better protects against GVHD after an allogeneic stem cell transplant than the standard therapy in people with blood cancers.
Recently diagnosed with breast cancer? Learn what to expect during radiation therapy from radiation oncologist Chelain Goodman, M.D., Ph.D.
A recent study study sheds light on how a protein called amyloid precursor protein (APP) affects the growth of nerve cells in the cortex — the human brain’s outer layer. The findings suggest that APP plays a crucial role in maintaining the delicate balance between neural stem cell proliferation and differentiation during the early stages of brain development.
The research, published in Science Advances, could have important implications for our understanding of neurodevelopmental processes and neurodegenerative diseases.
APP is a class I transmembrane protein that is widely expressed during nervous system development. It has been extensively studied due to its connection to Alzheimer’s disease (AD), where its fragmentation produces amyloid peptides that contribute to neuronal death. However, the physiological function of APP, especially in the context of human brain development, has remained unclear.
A team of scientists recently aimed to better understand consciousness and its pathologies by studying the neural activity of patients with disorders of consciousness and healthy volunteers using brain imaging technology. They identified two crucial brain circuits implicated in consciousness. The results of the study have been published in Human Brain Mapping.
Consciousness is a complex and subjective experience, and there is still much debate among scientists and philosophers about its nature and origin. However, in clinical settings, doctors treating patients with severe brain injuries and disorders of consciousness need to find ways to help their patients, regardless of the exact definition of consciousness. The authors of the new study sought to better understand the mechanisms behind the pathological loss of consciousness and its recovery, as well as to have reliable ways to assess the state of the patients.
“In recent years, many studies have tried to objectively assess levels of consciousness using various neuroimaging techniques. While these studies have improved how we diagnose patients with disorders of consciousness, they haven’t fully explained how consciousness comes about,” explained study author Jitka Annen, a postdoctoral researcher at the Coma Science Group at the University of Liege.
Neuroscientists have worked for decades to decode what people are seeing, hearing or thinking from brain activity alone. In 2012 a team that included the new study’s senior author—cognitive neuroscientist Robert Knight of the University of California, Berkeley—became the first to successfully reconstruct audio recordings of words participants heard while wearing implanted electrodes. Others have since used similar techniques to reproduce recently viewed or imagined pictures from participants’ brain scans, including human faces and landscape photographs. But the recent PLOS Biology paper by Knight and his colleagues is the first to suggest that scientists can eavesdrop on the brain to synthesize music.
“These exciting findings build on previous work to reconstruct plain speech from brain activity,” says Shailee Jain, a neuroscientist at the University of California, San Francisco, who was not involved in the new study. “Now we’re able to really dig into the brain to unearth the sustenance of sound.”
Continue reading “Neuroscientists Re-create Pink Floyd Song from Listeners’ Brain Activity” »
A breakthrough at the Massachusetts Institute of Technology (MIT), funded by the Department of Energy (DOE), is utilizing the power of DNA to align quantum rods that may help usher in a new era of enhanced televisions and ultra-realistic virtual reality (VR) devices.
Some modern high-end TVs already make use of the dynamic luminescent qualities of two-dimensional (2D) quantum dots, but finding a way to tap into the superior qualities of their two-dimensional cousins, quantum rods, has remained elusive. However, the researchers behind this latest effort claim that the situation has now changed.
The Secrets of Realistic VR and Star Trek Holodecks May Lie in the Quantum Realm.
A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.
Study: Small molecule targeting of transcription-replication conflict for selective chemotherapy. Image Credit: Lightspring/Shutterstock.com.
The physics of cell communication: ISTA scientists successfully model cell dynamics.
Like us, cells communicate. Well, in their own special way. Using waves as their common language, cells tell one another where and when to move. They talk, they share information, and they work together – much like the interdisciplinary team of researchers from the Institute of Science and Technology Austria (ISTA) and the National University of Singapore (NUS). They conducted research on how cells communicate – and how that matters to future projects, e.g. application to wound healing.
Biology may evoke images of animals, plants, or even theoretical computer models. The last association might not immediately come to mind, yet it is crucial in biological research. Complex biological phenomena, even the minutest details, can be understood through precise calculations. ISTA Professor Edouard Hannezo utilizes these calculations to comprehend physical principles in biological systems. His team’s recent work provides new insights into how cells move and communicate within living tissue.
Scientists at Stanford University have found a way to induce cell death in cancer cells with a method that could be effective in around 50% of cancers. In a paper, “Rewiring cancer drivers to activate apoptosis,” published in Nature, the team describes a new class of molecules called transcriptional/epigenetic CIPs (TCIPs) that can activate apoptosis with the help of cancer growth gene expressions within the cancer cells.
The researchers designed small molecules that bind specific transcriptional suppressors to transcription activators. The most potent molecule created, TCIP1, works by linking small molecules that bind BCL6 to those that bind transcriptional activators BRD4.
One of the components that makes cancer cells cancerous is that they ignore signals from surrounding healthy tissues to stop growing and to initiate apoptosis or cell death. The apoptosis pathways still exist but are actively blocked in certain types of cancer where the transcription factor B cell lymphoma 6 (BCL6) binds to the promoters of apoptosis genes and suppresses their expression through epigenetic mechanisms.
