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Snap judgments: How first impressions of faces shape inferences of mental states

When we first meet another person, we typically form an initial impression of them based on their facial features and appearance. These first impressions of others could potentially influence our subsequent cognitive processes, such as what mental states we believe that the people we meet are experiencing at a given time.

Researchers at the University of California San Diego (UCSD), the California Institute of Technology and Dartmouth College carried out a study investigating the potential relationship between first impressions of faces and the inference of mental states. Their findings, published in Nature Human Behavior, suggest that first impressions of faces influence the inference of other people’s mental states.

“Over the years there have been a lot of surprising findings showing how first impressions from faces can predict important outcomes, such as which candidates would win an election, which politicians would be convicted of corruption, and which offenders would be sentenced to death,” Chujun Lin, first author of the paper, told Medical Xpress.

Scientists identify 11 genes affected by PFAS, shedding light on neurotoxicity

Per-and polyfluorinated alkyl substances (PFAS) earn their “forever chemical” moniker by persisting in water, soil and even the human brain. This unique ability to cross the blood-brain barrier and accumulate in brain tissue makes PFAS particularly concerning, but the underlying mechanism of their neurotoxicity must be studied further.

To that end, a new study by University at Buffalo researchers has identified 11 genes that may hold the key to understanding the brain’s response to these pervasive chemicals commonly found in everyday items. The paper is published in the journal ACS Chemical Neuroscience.

These genes, some involved in processes vital for neuronal health, were found to be consistently affected by PFAS exposure, either expressing more or less, regardless of the type of PFAS compounds tested. For example, all compounds caused a gene key for neuronal cell survival to express less, and another gene linked to neuronal cell death to express more.

Genetic discovery offers hope for personalized epilepsy treatments

Recent research led by UTHealth Houston scientists has uncovered two genes associated with variants linked to epilepsy, which showed specific traits that make them promising diagnostic biomarkers.

The study is published in Nature Communications.

Led by Dennis Lal, Ph.D., director of the Center for Neurogenetics and associate professor of neurology at McGovern Medical School at UTHealth Houston, the research team analyzed data from 1,386 human brain tissues for somatic variants in the of individuals undergoing . Somatic variants are DNA changes that occur after conception and can only be identified in the brain tissue.

Controlling Human Body Temperature to Mimic Hibernation

Summary: Researchers have discovered a way to control human body temperature, mimicking the hibernation process of animals like bears. By manipulating the brain’s temperature regulation system, they can induce a state of “thermoregulatory inversion” (TI) in rats, reducing heat production even in cold environments.

This breakthrough could lead to controlled hypothermia in humans, improving survival rates in life-threatening situations like heart attacks and strokes. The discovery opens the door to therapeutic hypothermia, which can protect tissues from damage by lowering metabolism and oxygen demand.

New AI tool uses routine blood tests to predict immunotherapy response for many cancers

Doctors around the world may soon have access to a new tool that could better predict whether individual cancer patients will benefit from immune checkpoint inhibitors—a type of immunotherapy—using only routine blood tests and clinical data.

The artificial intelligence–based model, dubbed SCORPIO, was developed by a team of researchers from Memorial Sloan Kettering Cancer Center (MSK) and the Tisch Cancer Institute at Mount Sinai.

The model is not only cheaper and more accessible, it’s significantly better at predicting outcomes than the two current biomarkers approved by the U.S. Food and Drug Administration (FDA), according to findings published in Nature Medicine.

Telomerase enzyme research may help delay ageing and age-related diseases

BioViva focuses on translating this research into therapies.

In the search to extend human lifespan and address age-related diseases, telomerase reverse transcriptase (TERT) stands out as a promising focus of research. This enzyme, known for its role in maintaining telomeres—the protective caps at the ends of chromosomes—offers potential pathways to combat ageing at a cellular level. BioViva, under the leadership of CEO Liz Parrish, is working to transform telomerase-based scientific breakthroughs into tangible therapies aimed at enhancing health and longevity.

This Water-Resistant Paper Could Revolutionize Packaging and Replace Plastic

A groundbreaking study showcases the creation of sustainable hydrophobic paper, enhanced by cellulose nanofibres and peptides, presenting a biodegradable alternative to petroleum-based materials, with potential uses in packaging and biomedical devices.

Researchers aimed to develop hydrophobic paper by leveraging the strength and water resistance of cellulose nanofibers, creating a sustainable, high-performance material suitable for packaging and biomedical applications. This innovative approach involved integrating short protein chains, known as peptide sequences, without chemically altering the cellulose nanofibers. The result is a potential alternative to petroleum-based materials, with significant environmental benefits.

The study, titled “Nanocellulose-short peptide self-assembly for improved mechanical strength and barrier performance,” was recently featured on the cover of the Journal of Materials Chemistry B. The research was conducted by the “Giulio Natta” Department of Chemistry, Materials, and Chemical Engineering at Politecnico di Milano, in collaboration with Aalto University, the VTT-Technical Research Centre of Finland, and the SCITEC Institute of the CNR.

“Selective Silencing”: New Research Challenges Textbook Principle of Genetics

Why it matters

The new study explains a longstanding puzzle in medicine: why do some people who’ve inherited a disease-causing mutation experience fewer symptoms than others with the same mutation? “In many diseases, we’ll see that 90% of people who carry a mutation are sick, but 10% who carry the mutation don’t get sick at all,” says Bogunovic, a scientist who studies children with rare immunological disorders at Columbia University Irving Medical Center.

Enlisting an international team of collaborators, the researchers looked at several families with different genetic disorders affecting their immune systems. In each case, the disease-causing copy was more likely to be active in sick patients and suppressed in healthy relatives who had inherited the same genes.

Genes can now be studied by bending DNA strands with light

In a groundbreaking study, scientists have discovered a way to manipulate the very fabric of life by using light to reshape DNA strands. This innovative approach provides new insights into the material properties of chromosomes, unlocking potential advancements in understanding gene expression and developing treatments for genetic diseases.

Chromatin, the material that makes up chromosomes, is a complex structure where long strands of DNA are wrapped tightly around proteins. Despite its compact nature, chromatin must unfurl in certain regions to allow cells to access and replicate genetic information.

Some areas remain rigid and coiled, silencing genes, while others are flexible and accessible, facilitating gene expression. This duality has led scientists to question whether chromatin behaves like a solid, a liquid, or a hybrid of both.