Lifeboat Foundation

MIT biological engineers have created a programming language that allows them to rapidly design complex, DNA-encoded circuits that give new functions to living cells.

Using this language, anyone can write a program for the function they want, such as detecting and responding to certain environmental conditions. They can then generate a DNA sequence that will achieve it.

“It is literally a programming language for bacteria,” says Christopher Voigt, an MIT professor of biological engineering. “You use a text-based language, just like you’re programming a computer. Then you take that text and you compile it and it turns it into a DNA sequence that you put into the cell, and the circuit runs inside the cell.”

According to epigenetics — the study of inheritable changes in gene expression not directly coded in our DNA — our life experiences may be passed on to our children and our children’s children. Studies on survivors of traumatic events have suggested that exposure to stress may indeed have lasting effects on subsequent generations.

But exactly how are these genetic “memories” passed on?

Continue reading “On/off button for passing along epigenetic ‘memories’ to our children discovered” »

Biomedical engineering researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a technique that uses a patch embedded with microneedles to deliver cancer immunotherapy treatment directly to the site of melanoma skin cancer. In animal studies, the technique more effectively targeted melanoma than other immunotherapy treatments.

According to the CDC, more than 67,000 people in the United States were diagnosed with melanoma in 2012 alone – the most recent year for which data are available. If caught early, melanoma patients have a 5-year survival rate of more than 98 percent, according to the National Cancer Institute. That number dips to 16.6 percent if the cancer has metastasized before diagnosis and treatment. Melanoma treatments range from surgery to chemotherapy and radiation therapy. A promising new field of cancer treatment is cancer immunotherapy, which helps the body’s own immune system fight off cancer.

3D printed heart replicas, A new type of colossal galaxy, shutting down HIV with gene editing, and more!

This Week in Science — March 20 −27, 2016.

3D printed heart replicas, A new type of colossal galaxy, shutting down HIV with gene editing, and more.

1st of many steps in the gene editing oversight.

PRINCETON, N.J., March 29, 2016 /PRNewswire/ — WIRB-Copernicus Group^® (WCG™), one of the world’s leading providers of solutions that measurably improve the quality and efficiency of clinical research, today announced that it has assembled a team of world-renowned experts to advise the company regarding the latest advances in gene therapy research. The WCG Gene Therapy™ Advisory Board will convene today in Princeton, NJ.

“Human gene therapy is one of the fastest-growing areas of medical research, and also one of the most promising,” said WCG Chairman and Chief Executive Officer Donald A. Deieso, Ph.D. “The advances made by scientists and clinicians in the field of gene therapy have enabled us to target disease at the genetic level, redefining the concept of precision medicine.” He added, “More than that, gene transfer researchers have succeeded – over the course of a single lifetime – in transforming the world’s most persistent and lethal viruses into disease-fighting allies in the quest to improve human health.”

Continue reading “WIRB-Copernicus Group Establishes WCG Gene Therapy Advisory Board” »

Synthetic biology involves creating or re-engineering microbes or other organisms to perform specific tasks, like fighting obesity, monitoring chemical threats or creating biofuels. Essentially, biologists program single-celled organisms like bacteria and yeast much the same way one would program and control a robot.

But 10 years ago, it was extremely challenging to take a DNA sequence designed on a computer and turn it into a polymer that could implement its task in a specific host, say a mouse or human cell. Now, thanks to a multitude of innovations across computing, engineering, biology and other fields, researchers can type out any DNA sequence they want, email it to a synthesis company, and receive their completed DNA construct in a week. You can build entire chromosomes and entire genomes of bacteria in this way.

Continue reading “Magic Microbes: The Navy’s Next Defense?” »

Now, we have to truly ask ourselves; when one looks at all of the complexities of the brain and how it interacts with the body such as pathways; and then you look at our existing digital infrastructure and technology how can anyone truly believe that they can mimic the human brain and all of its functions. Not on the existing digital platform, not happening. We need a way more advance platform and infrastructure.

Suppose it’s Thursday night and you’re in bed. Your roommate is talking to you about the football team’s chances for the fall, but just when they predict a Tiger playoff berth, you drift off to sleep.

Enzo Tagliazucchi, a physicist at the Institute for Medical Psychology in Kiel, Germany, might explain why you fell asleep during the conversation by suggesting that your neurons are too disconnected.

Continue reading “Tigra scientifica: A pathway to consciousness” »

Hmmm;

Researchers are testing mild electrical stimulation to improve brain function and mental health, but warn do-it-yourselfers to be wary of treating themselves with models available online.

Dr. Fidel Vila-Rodriguez, director of the Non-Invasive Neurostimulation Therapies (NINET) Lab at the University of B.C., is starting to lend devices for home use to people with Parkinson’s disease and depression that will deliver a weak electrical current through electrodes placed on their temples.

Continue reading “Experts wary of electrical brain stimulation at home” »