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A step toward plant-based gelatin: Gum tragacanth shows promise for reducing animal use

With increased awareness about food sources and their environmental impacts, replacing animal-derived products in food and drugs is a significant research area. One common—but often overlooked—animal protein is gelatin, found everywhere from candy to plastic-free packaging.

In Physics of Fluids, researchers from the University of Ottawa present gum tragacanth as a plant-based alternative to for creating edible films.

“Gelatin has unique properties and its use is versatile,” said author Ezgi Pulatsu. “To fully replace gelatin, we must replicate its microstructure and understand its function in different applications.”

‘Superhuman vision’: Powerful 3D imaging technology paves way for next-generation eye-tracking

Eye tracking plays a critical role in the latest virtual and augmented reality headsets and is an important technology in the entertainment industry, scientific research, medical and behavioral sciences, automotive driving assistance and industrial engineering. Tracking the movements of the human eye with high accuracy, however, is a daunting challenge.

Researchers at the University of Arizona Wyant College of Optical Sciences have now demonstrated an innovative approach that could revolutionize eye-tracking applications.

Their study, published in Nature Communications, finds that integrating a powerful 3D imaging technique known as deflectometry with advanced computation has the potential to significantly improve state-of-the-art eye tracking technology.

Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism

I very much enjoyed reading this nicely done preclinical study on using nebulized vasopressin to improve social cognition in low-sociality rhesus monkeys. Reading about their study design in particular was highly informative/educational! #preclinical #medicine #biomedicine


Low cerebrospinal (CSF) arginine vasopressin (AVP) concentration is a biomarker of social impairment in low-social monkeys and children with autism, suggesting that AVP administration may improve primate social functioning. However, AVP administration also increases aggression, at least in “neurotypical” animals with intact AVP signaling. Here, we tested the effects of a voluntary drug administration method in low-social male rhesus monkeys with high autistic-like trait burden. Monkeys received nebulized AVP or placebo, using a within-subjects design. Study 1 (N = 8) investigated the effects of AVP administration on social cognition in two tests comparing responses to social versus nonsocial stimuli. Test 1: Placebo-administered monkeys lacked face recognition memory, whereas face recognition memory was “rescued” following AVP administration.

Non-ICANS neurological complications after CAR T-cell therapies: recommendations from the EBMT Practice Harmonisation and Guidelines Committee

Neurological complications are an important concern in patients undergoing chimeric antigen receptor (CAR) T-cell therapy. Consensus guidelines inform the management of immune effector cell-associated neurotoxicity syndrome (ICANS). However, these guidelines are based on the early clinical experience with CD19 targeting CAR T cells in B-cell malignancies. In contrast, there are so far no published best practice recommendations on the current management of other non-classical neurological complications, which frequently develop after CAR T-cell infusion and cause clinically significant neurotoxicity.

Plant cells gain immune capabilities when it’s time to fight disease

LA JOLLA—Human bodies defend themselves using a diverse population of immune cells that circulate from one organ to another, responding to everything from cuts to colds to cancer. But plants don’t have this luxury. Because plant cells are immobile, each individual cell is forced to manage its own immunity in addition to its many other responsibilities, like turning sunlight into energy or using that energy to grow. How these multitasking cells accomplish it all—detecting threats, communicating those threats, and responding effectively—has remained unclear.

Illuminating single atoms for sustainable propylene production

More than 150 million metric tons of propylene are produced annually, making it one of the most widespread chemicals used in the chemical industry.

Propylene is the basis for polypropylene, a polymer used in everything from medical devices to packaging to household goods. But most is produced through steam cracking, a high-energy process that uses heat to break down crude oil into smaller hydrocarbons.

Now, Northwestern University chemists have found a way to create propylene using light. Their findings show that a nanoengineered photoactive catalyst can make propylene directly through a process called nonoxidative propane dehydrogenation (PDH).

Healing chronic wounds three times faster with electricity

Researchers from both Chalmers University of Technology, Sweden, and the University of Freiburg, Germany, have been collaborating on a project to help those who suffer from chronic wounds heal faster than ever before and therefore negate the possibility of amputation in severe cases.

Commonly a small wound does not lead to any serious complications; however, for those with diabetes, spinal injuries or poor blood circulation, a small wound means a greater risk of infection and chronic wounds – which in the long run can lead to much more serious consequences such as amputation.

Maria Asplund, Associate Professor of Bioelectronics at Chalmers University of Technology and head of research on the project explained that “Chronic wounds are a huge societal problem that we don’t hear a lot about. Our discovery of a method that may heal wounds up to three times faster can be a game changer for diabetic and elderly people, among others, who often suffer greatly from wounds that won’t heal.”

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