Lifeboat Foundation

The human brain is a remarkably complex organ, consisting of billions of interconnected neurons. It can be divided into distinct regions, each with specific functions, such as memory and decision-making. Cognition, which includes processes like perception, memory, language, and problem-solving, is all orchestrated by the brain. It’s through these cognitive processes that we perceive and interact with the world around us.

What is special about the structure of the brain compared to other organs? What is the principled way of understanding how the brain works? How does the brain contribute to our sense of Self? Is it possible to compare the brain with the computer? Is it possible to enhance the way that the brain works? What is the brain-basis of language?

Continue reading “Exploring the Brain: from Synapses to Cognition” »

face_with_colon_three year 2023 The ultimate goal is to use crispr to modify genetic programming for eternal life this an example of heart age reversal.

An anti-aging gene found in centenarians has been shown to reverse the heart’s biological age by 10 years. This groundbreaking discovery, published in the journal Cardiovascular Research and led by scientists from the University of Bristol and MultiMedica Group in Italy, offers a potential target for heart failure patients.

Individuals who carry healthy mutant genes, commonly found in populations known for exceptional longevity such as the “blue zones,” often live to 100 years or more and remain in good health. These carriers are also less susceptible to cardiovascular complications. Scientists funded by the British Heart Foundation believe the gene helps keep their hearts youthful by guarding against diseases related to aging, such as heart failure.

Continue reading “Anti-Aging Gene Shown To Rewind Heart Age by 10 Years” »

When looking into the future, there are a number of interesting trends, such as quantum computing, which may save lots of energy, or space travel, which is here to stay and will become more affordable. But what I find interesting is the development of computation with biological cells, and the ability to build computing systems, and robots, not from hard metals but from soft biological matter — mostly cells.

Look around you in “nature”- almost everything you see, all plants and animals are built from a single type of structure, a biological cell. They are all alike. Sure, cells vary as they adapt to their environments, but a cellular organism has the same building plan as any other cell. There’s the cell membrane, there is a nucleus, there are organelles and cytoplasm. There is DNA, RNA, amino acids to build proteins and peptides, lipids and sugars. Put together in predictable ways.

We are learning to use these systems to build anything we want from them. We focus on this because our bodies are made from cells, and we want to remain healthy. That is a strong incentive to study these systems. The convergence will happen when we relegate metal-based computing to the sidelines and focus on biological computing as our main systems. These biological cell systems are, incidentally, quantum computing systems. So the trends I mention — here on earth will converge, and only space travel will require the opposite — the need to shield biological computing from conditions in space.

Abstract: By harnessing the power of composite polymer particles adorned with gold nanoparticles, a group of researchers have delivered a more accurate means of testing for infectious diseases.

Details of their research was published in the journal Langmuir.

The COVID-19 pandemic reinforced the need for fast and reliable infectious disease testing in large numbers. Most testing done today involves antigen-antibody reactions. Fluorescence, absorptions, or color particle probes are attached to antibodies. When the antibodies stick to the virus, these probes visualize the virus’s presence. In particular, the use of color nanoparticles is renowned for its excellent visuality, along with its simplicity to implement, with little scientific equipment needed to perform lateral flow tests.

Scientists from Washington University in St.

Antibody mobilizes immune cells to clear amyloid plaques, reducing behavioral abnormalities.

Summary: Researchers made a groundbreaking discovery about the maturation process of adult-born neurons in the brain, highlighting the critical role of mitochondrial fusion in these cells. Their study shows that as neurons develop, their mitochondria undergo dynamic changes that are crucial for the neurons’ ability to form and refine connections, supporting synaptic plasticity in the adult hippocampus.

This insight, which correlates altered neurogenesis with neurological disorders, opens new avenues for understanding and potentially treating conditions like Alzheimer’s and Parkinson’s by targeting mitochondrial dynamics to enhance brain repair and cognitive functions.

Gene therapy may be the best hope for curing retinitis pigmentosa (RP), an inherited condition that usually leads to severe vision loss and blinds 1.5 million people worldwide.

But there’s a huge obstacle: RP can be caused by mutations in over 80 different genes. To treat most RP patients with gene therapy, researchers would have to create a therapy for each gene—a nearly impractical task using current gene therapy strategies.

A more universal treatment may be forthcoming. Using CRISPR-based genome engineering, scientists at Columbia University Vagelos College of Physicians and Surgeons are designing a gene therapy with the potential to treat RP patients regardless of the underlying genetic defect.

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer’s disease and frontotemporal dementia. This new model has led to the identification of novel therapeutic targets that could potentially block tau spread.

An automated counterflow centrifugation–based technology outperforms manual peripheral blood mononuclear cell (PBMC) isolation.