Lifeboat Foundation

More than 100 COVID-19 patients at a hospital in Beijing are receiving injections of mesenchymal stem cells to help them fend off the disease. The experimental treatment is part of an ongoing clinical trial, which coordinators say has shown early promise in alleviating COVID-19 symptoms.

Several experts express skepticism of the trial’s early results, suggest resources would be better spent exploring other treatments.

Working around the clock, scientists at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts can run about 2,000 COVID-19 tests per day. In places where testing is still scarce — which is to say much of the world — similar efforts can provide vital relief to public-health systems stretched to their limits. As they shutter their labs indefinitely, tens of thousands of scientists are volunteering to help the pandemic relief efforts in any way they can.

As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise.

Covid-19 is a respiratory infection that damages the lungs. New evidence has emerged that Covid-19 also causes damage to the heart even with no preexisting conditions:

Objective To explore the association between cardiac injury and mortality in patients with COVID-19.

Design, Setting, and Participants This cohort study was conducted from January 20, 2020, to February 10, 2020, in a single center at Renmin Hospital of Wuhan University, Wuhan, China; the final date of follow-up was February 15, 2020. All consecutive inpatients with laboratory-confirmed COVID-19 were included in this study.

Continue reading “Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China” »

Abbott Laboratories is unveiling a coronavirus test that can tell if someone is infected in as little as 5 minutes, and is so small and portable it can be used in almost any health-care setting.

The Army has a message for its retirees: Uncle Sam wants you to help fight the novel coronavirus.

A message sent by Defense Finance and Accounting Services, which processes and dispenses retiree pay, asked troops who had previously served in specific health care specialties to consider “re-joining the team” to address the current pandemic crisis. It’s signed by Lt. Gen. Thomas Seamands, deputy chief of staff for U.S. Army Personnel, G-1.

“We need to hear from you STAT!” reads the message, obtained by Military.com.

Circa 2017

Plant viruses, the simple obligate intracellular parasites with small genomes, rely entirely on host machineries for their life cycle including replication, intracellular (cell-to-cell) and systemic movement (Nelson and Citovsky, 2005). Virus infections pose serious threats to agriculture and cause huge economic losses. Despite encoding only a limited number of proteins, numerous interactions of viral RNAs/proteins with host factors have puzzled the plant virologists for over a century and the complexity of these interactions is just becoming understood.

Plants have developed two major strategies to counteract virus infections: resistance (R) gene-mediated, and RNA silencing-based defenses. In addition, the mutation in essential genes for viral infection also causes plant resistance against viruses, called recessive gene-mediated resistance. These approaches have been used in crop protections and have shown significant economic impact (Abel et al., 1986; Whitham et al., 1996; Baulcombe, 2004; Kang et al., 2005; Wang and Krishnaswamy, 2012).

This Research Topic combines 13 publications, including 9 review articles and 4 research articles, covering almost every aspect of plant-virus interactions. The featured in-depth topic reviews in various sub-fields provide readers a convenient way to understand the current status of the related sub-fields and the featured research articles expand the current knowledge in related sub-fields.

Circa 2016

Air pollution has a significant and pervasive impact on public health. According to the World Health Organization, it is now considered “the world’s largest single environmental health risk,” with more than three million people dying every year as a result. This is more than twice the number of people that die in vehicle accidents each year.

Health and safety are important to us. Just as we’ve designed Model S and Model X to avoid collisions or protect their occupants when one happens, we felt compelled to protect them against the statistically more relevant hazard of air pollution*. Inspired by the air filtration systems used in hospitals, clean rooms, and the space industry, we developed a HEPA filtration system capable of stripping the outside air of pollen, bacteria, and pollution before they enter the cabin and systematically scrubbing the air inside the cabin to eliminate any trace of these particles. The end result is a filtration system hundreds of times more efficient than standard automotive filters, capable of providing the driver and her passengers with the best possible cabin air quality no matter what is happening in the environment around them.

Continue reading “Putting the Tesla HEPA Filter and Bioweapon Defense Mode to the Test” »

Circa 2000

The intentional release of biological agents by belligerents or terrorists is a possibility that has recently attracted increased attention. Law enforcement agencies, military planners, public health officials, and clinicians are gaining an increasing awareness of this potential threat. From a military perspective, an important component of the protective pre-exposure armamentarium against this threat is immunization. In addition, certain vaccines are an accepted component of postexposure prophylaxis against potential bioterrorist threat agents. These vaccines might, therefore, be used to respond to a terrorist attack against civilians. We review the development of vaccines against 10 of the most credible biological threats.

Most simply, the phrase “genome editing” represents tools and techniques that biotechnologists use to edit the genome — that is, the DNA or RNA of plants, animals, and bacteria. Though the earliest versions of genome editing technology have existed for decades, the introduction of CRISPR in 2013 “brought major improvements to the speed, cost, accuracy, and efficiency of genome editing.”

CRISPR, or Clustered Regularly Interspersed Short Palindromic Repeats, is actually an ancient mechanism used by bacteria to remove viruses from their DNA. In the lab, researchers have discovered they can replicate this process by creating a synthetic RNA strand that matches a target DNA sequence in an organism’s genome. The RNA strand, known as a “guide RNA,” is attached to an enzyme that can cut DNA. After the guide RNA locates the targeted DNA sequence, the enzyme cuts the genome at this location. DNA can then be removed, and new DNA can be added. CRISPR has quickly become a powerful tool for editing genomes, with research taking place in a broad range of plants and animals, including humans.

A significant percentage of genome editing research focuses on eliminating genetic diseases. However, with tools like CRISPR, it also becomes possible to alter a pathogen’s DNA to make it more virulent and more contagious. Other potential uses include the creation of “‘killer mosquitos,’ plagues that wipe out staple crops, or even a virus that snips at people’s DNA.”