Lifeboat Foundation

Being an astronaut looks like an exciting and glamorous career. But have you ever thought about the dangers that these people face by being exposed to extreme conditions, such as radiation and microgravity?

Living and working in microgravity can impact your whole body in different ways. On the other hand, the human body is capable of adapting its physiology to survive in diverse conditions.

Lipitoids, which self-assemble with DNA and RNA, can serve as cellular delivery systems for antiviral therapies that could prevent COVID-19 and other coronavirus infections. Credit: Illustration courtesy of R.N. Zuckermann.

Mentions aging!

Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population. With obesity comes a variety of other interconnected diseases including cardiovascular disease, diabetes, and fatty liver disease, which makes the disease one of the most difficult—and most crucial—to treat.

“Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society,” said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.

Continue reading “Drug researcher develops ‘fat burning’ molecule that has implications for treatment of obesity” »

Persistently engaging in negative thinking patterns may raise the risk of Alzheimer’s disease, finds a new UCL-led study.

In the study of people aged over 55, published in Alzheimer’s & Dementia, researchers found ‘repetitive negative thinking’ (RNT) is linked to subsequent cognitive decline as well as the deposition of harmful brain proteins linked to Alzheimer’s.

The researchers say RNT should now be further investigated as a potential risk factor for dementia, and psychological tools, such as mindfulness or meditation, should be studied to see if these could reduce dementia risk.

Many scientists are eager to discuss the possibilities of using gene editing to preserve biodiversity.

Though scientists are optimistic that CRISPR could help, they also emphasize caution and community engagement in order to get it right.

For the first time, Italian scientists have been able to identify the genetic and molecular basis of this susceptibility to infection as well as to the possibility of contracting a more severe form of the disease. The research will be presented to the 53rd annual conference of the European Society of Human Genetics, being held entirely on-line due to the Covid-19 pandemic, today [Saturday].

As we head into summer, it’s hard not to think about traveling. Not only it is the traditional season for vacations, but we’ve also been cooped up inside for months and most of us are probably itching to explore something new. Of course, given that we’re in the middle of a global pandemic where travel—especially by plane—isn’t a great idea, planning a trip may be more fantasy than reality these days. Either way, you may be curious about which countries have opened up to tourists. If so, an interactive map put out by the International Airline Transportation Association is a great tool.

Light-sheet images of DEEP-Clear processed zebrafish showing proliferative cells (pink) and the nervous system (green). Credit: TU Wien / Max Perutz Labs.

An important observation that helped to develop the new method was that the combination of different chemical treatments had a synergistic effect, allowing for fast depigmentation and tissue clearing. “Shortening chemical processing preserves the integrity of tissues and organisms, so that the molecules and internal structures of interest are more likely to be retained,” explains Marko Pende, the developer of the clearing method, from the lab of Hans-Ulrich Dodt at the TU Wien and the Center for Brain Research (CBR) of the Medical University of Vienna, and one of the first authors of the study. This way multiple organisms could be imaged from different clades ranging from mollusks to bony fish to amphibians. “These are just a few examples. We believe that the method is applicable to multiple organisms. It was just not tried yet”, explains Prof. Hans Ulrich Dodt, senior author of the study.

Virus DNA left on a hospital bed rail was found in nearly half of all sites sampled across a ward within 10 hours and persisted for at least five days, according to a new study by UCL and Great Ormond Street Hospital (GOSH).

The study, published as a letter in the Journal of Hospital Infection, aimed to safely simulate how SARS-CoV-2, the virus that causes Covid-19, may spread across surfaces in a hospital.

Instead of using the SARS-CoV-2 virus, researchers artificially replicated a section of DNA from a plant-infecting virus, which cannot infect humans, and added it to a milliliter of water at a similar concentration to SARS-CoV-2 copies found in infected patients’ respiratory samples.