Lifeboat Foundation

UK biotech valued at $500m will use public offering to move 5 life-extension technologies into phase 2 trials.

Japanese researchers have created a smart face mask that has a built in speaker and can translate speech into 8 different languages.

We live in a world full of technology but it was a world without smart masks, until now!

A Japanese technology company Donut Robotics has taken the initiative to create the first smart face masks which connects to your phone. Of course, we couldn’t have battled coronavirus with a simple mask that still does the job of protecting us perfectly well. We as a race need to bring technology into everything and more so if it does an array of extremely important, life-saving things like using a speaker to amplify a person’s voice, covert a person’s speech into text and then translate it into eight different languages through a smartphone app.

Under certain circumstances in patients, the human immune system can spin out of control and become highly toxic, resulting in cytokine release syndrome (CRS). CRS has been observed in certain autoimmune diseases (Grom et al. 2016), during highly infectious diseases like COVID-19 (Zhang et al. 2020), and following immune-enhancing treatments that include monoclonal or bispecific antibodies, or CAR T therapies (Shimabukuro-Vornhagen et al. 2018). CRS, which can be deadly, has been notoriously difficult to study and for which to develop novel treatments. However, encouraging new data indicates that many aspects of human CRS can be modeled in immunodeficient NSG mice engrafted with human peripheral blood mononuclear cells (PBMCs). This model provides hope that new immuno-modulatory therapies can be safely developed and tested before clinical trials.

Figure 1. TGN1412 analogue (anti-CD28 superagonist) mediated CRS dose response. Human PBMC engrafted NSG™-SGM3 recipient mice (stock# 013062) were treated with anti-CD28 mAb positive control or TGN1412 analogue at low, medium or high dosing. Human IFN- ɣ, TNF-α, and IL-6 were measured quantitatively at 1, 2, 4, and 6 hours post treatment. Increasing doses of TGN1412 analogue showed a progressively increased cytokine release response.

The next question was whether PBMC donor-specific differences in drug response could be observed, mimicking what is observed clinically. Cohorts of mice were engrafted with nine different human PBMC donors, and each donor cohort was tested with PBS, OKT3, or anti-CD28. In mice treated with OKT3, 7 out of 9 donors displayed a severe IFN-ɣ CRS response, 5 showed a severe IL-6 response and all exhibited a strong TNF-α response (figure 2). Donors G and H showed a milder response. When treated with anti-CD28, 2 out of 9 donors showed a severe IFN-ɣ response. Collectively, the data described in the experiments above demonstrate that specific mAbs are capable of initiating a CRS response in this model and that the response is both dose and PBMC donor dependent.

Continue reading “Battling COVID-19; A New Model of Cytokine Release Syndrome” »

Scientists from the University of California, Irvine School of Medicine have discovered a compound commonly found in capers, regulates proteins required for normal human brain and heart activity.

British Health Minister Matt Hancock said that the government would not recommend that office workers wear face masks while at work.

“We will not be recommending masks in the office,” Hancock told Sky News on Wednesday.

Nearly a dozen Indian states have imposed a partial lockdown in high-risk areas after spikes in coronavirus cases, with the country’s infections topping 900,000 just three days after crossing the 800,000 mark.

Bio-Wall forms a temporary flexible film over the mucosa of the nose, throat and oral cavity. Antiviral components in the bio-adhesive matrix are meant to trap the virus and block it.

“Once Bio-Wall is sprayed over the mucosa, it masks the tissue from pathogen penetration and infectious disease such as the Covid-19 virus” for several hours, says BioChange Chairman and CEO Ishay Attar.

A nasal spray in development and a surface-disinfecting spray already on the market are intended to keep us safe from virus particles in the air.

Evidence of SARS-CoV-2 transmission from mother to fetus 😢.

SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: maternal viremia, placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

An existing medicine can “downgrade” the danger-level of coronavirus to that of a common cold, a Jerusalem researcher is claiming, after testing it on infected human tissue.

Prof. Yaakov Nahmias says that his research shows that the novel coronavirus is so vicious because it causes lipids to be deposited in the lungs, and that there is a solution to undo the damage: a widely-used anti cholesterol drug called fenofibrate.

Hebrew University professor says he’s worked out what makes the raging virus so vicious, and how to fix it using an anti-cholesterol med; no human testing done yet.

Continue reading “Existing drug may downgrade COVID threat to common cold level — Jerusalem study” »

In 2003, history was made. For the first time, the human genome was sequenced. Since then, technological improvements have enabled tweaks, adjustments, and additions, making the human genome the most accurate and complete vertebrate genome ever sequenced.

Nevertheless, some gaps remain — including human chromosomes. We have a pretty good grasp of them in general, but there are still some gaps in the sequences. Now, for the first time, geneticists have closed some of those gaps, giving us the first complete, gap-free, end-to-end (or telomere-to-telomere) sequence of a human X chromosome.

The accomplishment was enabled by a new technique called nanopore sequencing, which enables ultra-long-reads of DNA strands, providing a more complete and sequential assembly.