Lifeboat Foundation

Pancreatic cancer is rarely detected at its early stages when it’s most curable. This is because it often doesn’t cause symptoms until after it has spread to other organs. Treatment options are chosen based on the extent of the cancer and may include surgery, chemotherapy, radiation therapy, or a combination of these. Using mice and lab-grown pancreas models, scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that they can stop the growth of pancreatic cancer cells by blocking the way the cells store cholesterol.

Their study, “SOAT1 promotes mevalonate pathway dependency in pancreatic cancer,” was published in the Journal of Experimental Medicine and led by David Tuveson, MD, PhD, professor at CSHL.

Tuveson’s team wanted to know why pancreatic cancer cells, like many cancer cells, produce abundant amounts of cholesterol. “Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC. However, the changes in cholesterol metabolism and their role during PDAC progression remain largely unknown. Here we used organoid and mouse models to determine the drivers of altered cholesterol metabolism in PDAC and the consequences of its disruption on tumor progression,” the scientists wrote.

Digital identity capabilities from Trust Stamp are now being integrated with Mastercard’s Wellness Pass solution, which it will launch in cooperation with Gavi in West Africa. Proving identity without revealing any information about it is the idea behind Trust Stamp’s zero knowledge approach to online identity verification, according to a profile by Mastercard.

Gareth Genner, Trust Stamp co-founder and CEO, explains in an interview how the company’s Evergreen Hash technology uses biometrics without taking on the risk of spoofing or a data breach that he says come with standard biometric implementations.

The Evergreen Hash is created from the customers face, palm or fingerprint biometrics, which the company uses to generate a “3D mask,” discarding raw data and adding encryption to associate the data with the user.

Please stop saying “There is no treatment for coronavirus”, coronavirus can be treated many ways. Anything can be treated many ways. When one says, “This can not be done”, one has already given up. When one says, “I can”, one at least makes an effort, and even failure is a lesson that leads to success. The WHO is already promoting the Moderna vaccine, yet it takes years to develop a vaccine properly. Any scientist will tell you it is faster to repurpose drugs than to develop a vaccine. Even in Kenya, they will not tell you how people are being treated, but already they are talking about the Moderna Vaccine.

Sometimes, old drugs find a new purpose. A widely available steroid called dexamethasone might hold the potential to save a lot of lives that otherwise would be lost to coronavirus. Preliminary results released from a randomized and controlled clinical trial involving more than 6,000 patients found that administering dexamethasone significantly reduced deaths among those with severe COVID-19 illnesses.

The study, which has not yet been published in a peer-reviewed journal, found that the drug reduced deaths by one-third among patients on mechanical ventilators, and by one-fifth among patients receiving other forms of supplemental oxygen. Although dexamethasone is a far cry from a coronavirus cure, it feels like the first good news to transpire since earlier this spring, when the antiviral drug remdesivir showed it could modestly improve survival among COVID-19 patients.

For the first time, scientists have introduced minuscule tracking devices directly into the interior of mammalian cells, giving an unprecedented peek into the processes that govern the beginning of development. This work on one-cell embryos is set to shift our understanding of the mechanisms that underpin cellular behaviour in general, and may ultimately provide insights into what goes wrong in ageing and disease.

The research, led by Professor Tony Perry from the Department of Biology and Biochemistry at the University of Bath, involved injecting a silicon-based nanodevice together with sperm into the egg cell of a mouse. The result was a healthy, fertilised egg containing a tracking device.

The tiny devices are a little like spiders, complete with eight highly flexible ‘legs’. The legs measure the ‘pulling and pushing’ forces exerted in the cell interior to a very high level of precision, thereby revealing the cellular forces at play and showing how intracellular matter rearranged itself over time.

Want to learn how we age and whether we can slow or even reverse aging? David Sinclair, PhD, professor of genetics at Harvard Medical School, says in his book “Lifespan” that aging is a disease, and that disease is treatable. Tune in to Homeroom with Sal on Tuesday at noon PT to get your questions answered by a leading expert on aging and age-associated diseases.

For more information visit: keeplearning.khanacademy.org

Continue reading “Homeroom with Sal & David Sinclair, PhD — Tuesday, July 14” »

A brilliant new light shines in Grenoble, France, where officials at the European Synchrotron Radiation Facility(ESRF) last week announced the reopening of their completely rebuilt x-ray source. The ring-shaped machine, 844 meters around, generates x-ray beams 100 times brighter than its predecessor and 10 trillion times brighter than medical x-rays. The intense radiation could open up new vistas in x-ray science, such as imaging whole organs in three dimensions while resolving individual cells.

Shining 100 times brighter than its predecessor, the new European Synchrotron Radiation Facility is the first of more than a dozen of its kind in the works.

(Reuters) — Nearly a third of more than 40 large companies seeking U.S. bankruptcy protection during the coronavirus pandemic awarded bonuses to executives within a month of filing their cases, according to a Reuters analysis of securities filings and court records.

Under a 2005 bankruptcy law, companies are banned, with few exceptions, from paying executives retention bonuses while in bankruptcy. But the firms seized on a loophole by granting payouts before filing.

Six of the 14 companies that approved bonuses within a month of their filings cited business challenges executives faced during the pandemic in justifying the compensation.

Do you agree with these predictions?

The first few months of 2020 have radically reshaped the way we work and how the world gets things done. While the wide use of robotaxis or self-driving freight trucks isn’t yet in place, the Covid-19 pandemic has hurried the introduction of artificial intelligence across all industries. Whether through outbreak tracing or contactless customer pay interactions, the impact has been immediate, but it also provides a window into what’s to come. The second annual Forbes’ AI 50, which highlights the most promising U.S.-based artificial intelligence companies, features a group of founders who are already pondering what their space will look like in the future, though all agree that Covid-19 has permanently accelerated or altered the spread of AI.

“We have seen two years of digital transformation in the course of the last two months,” Abnormal Security CEO Evan Reiser told Forbes in May. As more parts of a company are forced to move online, Reiser expects to see AI being put to use to help businesses analyze the newly available data or to increase efficiency.

Continue reading “AI 50 Founders Predict What Artificial Intelligence Will Look Like After Covid-19” »

Could be used for quasar propulsion: 3.

It seems the universe has an odd sense of humor. While a crown-encrusted virus has run roughshod over the world, another entirely different corona about 100 million light years from Earth has mysteriously disappeared.

For the first time, astronomers at MIT and elsewhere have watched as a supermassive black hole’s own corona, the ultrabright, billion-degree ring of high-energy particles that encircles a black hole’s event horizon, was abruptly destroyed.

Continue reading “In a first, astronomers watch a black hole’s corona disappear, then reappear” »