Lifeboat Foundation

“The logistics of clinical testing don’t let you sample everybody, but sewage does sample everybody.”-Steve Hrudey.

Raw sewage being flushed into Alberta’s municipal wastewater plants could help public health officials better track — and predict — the spread of COVID-19.

A team of Alberta scientists has joined a growing international effort to sample wastewater for traces of SARS-CoV-2, the virus responsible for the disease.

Continue reading “Alberta excrement being tested for COVID-19 as researchers refine sewage surveillance” »

A small energy harvesting device that can transform subtle mechanical vibrations into electrical energy could be used to power wireless sensors and actuators for use in anything from temperature and occupancy monitoring in smart environments, to biosensing within the human body.

In research recently published online in the Journal of Micromechanics and Microengineering, engineers at Rensselaer Polytechnic Institute developed a predictive model for such a device, which will allow researchers to better understand and optimize its functionalities.

“Sooner or later these harvesters will replace batteries, reducing associated environmentally hazardous waste and maintenance costs,” said Diana-Andra Borca-Tasciuc, a professor of mechanical, aerospace, and nuclear engineering at Rensselaer, who led this research effort.

Moderna is prepping for the global launch of its potential coronavirus vaccine, already taking in $1.1 billion in deposits from governments awaiting the potentially lifesaving drug, the biotech firm said Thursday in its third-quarter earnings report.

The Cambridge, Massachusetts-based company said it was in ongoing talks with the World Health Organization-backed COVAX initiative on a tiered pricing proposal for its potential vaccine, which it’s tentatively calling mRNA-1273. It already has supply agreements in North America, the Middle East and in other regions of the world.

“We are actively preparing for the launch of mRNA-1273 and we have signed a number of supply agreements with governments around the world,” Moderna CEO Stephane Bancel said in a press release. “Moderna is committed to the highest data quality standards and rigorous scientific research as we continue to work with regulators to advance mRNA-1273.”

Many of the fundamental principles in biology and essentially all pathways regulating development were identified in so-called genetics screens. Originally pioneered in the fruit fly Drosophila and the nematode C. elegans, genetic screens involve inactivation of many genes one by one. By analyzing the consequences of gene loss, scientists can draw conclusions about its function. This way, for example, all genes required for formation of a brain can be identified.

Genetic screens can routinely be carried out in flies and worms. In humans, a wealth of knowledge exists about genetic disorders and the consequences of disease-relevant mutations, but their systematic analysis was impossible. Now, the Knoblich lab at IMBA has developed a groundbreaking technique allowing hundreds of genes to be analyzed in parallel in human tissue. They named the new technology CRISPR-LICHT and published their findings in the journal Science.

By using cerebral organoids, a 3D cell culture model for the human brain developed in Jürgen Knoblich’s group at IMBA, hundreds of mutations can now be analyzed for their role in the human brain using CRISPR-LICHT.

More than a century ago, in 1910, President William Howard Taft made what then seemed a bold but reasonable prediction: “Within five years,” he said.

BOSTON (AP) — Federal agencies warned that cybercriminals are unleashing a wave of data-scrambling extortion attempts against the U.S. healthcare system designed to lock up hospital information systems, which could hurt patient care just as nationwide cases of COVID-19 are spiking.

In a joint alert Wednesday, the FBI and two federal agencies warned that they had “credible information of an increased and imminent cybercrime threat to U.S. hospitals and healthcare providers.” The alert said malicious groups are targeting the sector with attacks that produce “data theft and disruption of healthcare services.”

The cyberattacks involve ransomware, which scrambles data into gibberish that can only be unlocked with software keys provided once targets pay up. Independent security experts say it has already hobbled at least five U.S. hospitals this week, and could potentially impact hundreds more.

As cells bump into each other, forces cause them to move and shake, or even sometimes rupture.

“Cells are constantly generating forces and responding to them. They are being pulled on by their environment,” said Jonathan Winkelman, a postdoctoral researcher at the University of Chicago. Winkelman works in the lab of Margaret Gardel, professor in the Department of Physics and the Pritzker School of Molecular Engineering.

Unlike a rubber band that breaks when you stretch it too much, an overstretched cell initiates a response to repair itself. This phenomenon has been observed using microscopy, but the question of how the repair and adaptation process initiates inside the cells has remained unanswered until now.

Article. I guess having implants directly on the brain isn’t the only way to have a brain to machine interface. The scientists involved in the study found an alternative by picking up signals through the blood vessels.

It’s not as information packed as a direct brain connection, but it’s not as invasive.

I think it would be a good alternative or even complementary to direct brain implants. Interesting. 😃

Continue reading “A New Way to Plug a Human Brain Into a Computer: via Veins” »

While our circadian body clock dictates our preferred rhythm of sleep or wakefulness, a relatively new concept—the epigenetic clock—could inform us about how swiftly we age, and how prone we are to diseases of old age.

People age at different rates, with some individuals developing both characteristics and diseases related to aging earlier in life than others. Understanding more about this so-called ‘biological age’ could help us learn more about how we can prevent diseases associated with age, such as dementia. Epigenetic markers control the extent to which genes are switched on and off across the different cell-types and tissues that make up a human body. Unlike our genetic code, these epigenetic marks change over time, and these changes can be used to accurately predict biological age from a DNA sample.

Now, scientists at the University of Exeter have developed a new epigenetic clock specifically for the human brain. As a result of using human brain tissue samples, the new clock is far more accurate than previous versions, that were based on blood samples or other tissues. The researchers hope that their new clock, published in Brain and funded by Alzheimer’s Society, will provide insight into how accelerated aging in the brain might be associated with brain diseases such as Alzheimer’s disease and other forms of dementia.