Scientists at Cold Spring Harbor Laboratory (CSHL) and Stanford University have pinpointed the circuit in the brain that is responsible for sleepless nights in times of stress—and it turns out that circuit does more than make you toss and turn. Their study, done in mice, ties the same neuronal connections that trigger insomnia to stress-induced changes in the immune system, which weaken the body’s defenses against a host of threats.
The study, reported September 9, 2020, in the journal Science Advances, connects and explains two familiar problems, says CSHL Assistant Professor Jeremy Borniger. “This sort of stress-induced insomnia is well known among anybody that’s tried to get to sleep with a looming deadline or something the next day,” he says. “And in the clinical world, it’s been known for a long time that chronically stressed patients typically do worse on a variety of different treatments and across a variety of different diseases.”
Like many aspects of the body’s stress response, these effects are thought to be driven by the stress hormone cortisol. Working in the Stanford lab of Luis de Lecea, where Borniger completed a postdoctoral fellowship prior to joining CSHL, the research team found a direct connection between stress-sensitive neurons in the brain that trigger cortisol’s release and nearby neurons that promote insomnia.
His company, Rejuvenate Bio, has begun clinical trials in old dogs. This will help us determine which ages of humans would best benefit. George believes they will be able to help people who are already quite old and show signs of decline. They are looking at extending absolute lifespan. Extending human lifespan will take years to get reliable results.
They have published results on three genes. Those genes already helped reverse osteoarthritis, high-fat obesity and diabetes, heart damage, and kidney disease. They will soon add cancer and neurodegenerative diseases to the list of reversible conditions.
Researchers at the University of Sheffield have developed a new compound that is able to kill both gram-positive and gram-negative antibiotic-resistant bacteria.
Gram-positive and gram-negative bacteria have different cell wall structures, but the new antibiotic compound is able to pass through the cell wall of both forms of bacteria and then bind to the DNA.
The findings, published in Chemical Science, pave the way for developing new treatments for all kinds of antibiotic resistant bacteria, including the gram-positive MRSA and gram-negative E.Coli.
Like a comic book come to life, researchers at Stanford University have developed a kind of X-ray vision—only without the X-rays. Working with hardware similar to what enables autonomous cars to “see” the world around them, the researchers enhanced their system with a highly efficient algorithm that can reconstruct three-dimensional hidden scenes based on the movement of individual particles of light, or photons. In tests, detailed in a paper published Sept. 9 in Nature Communications, their system successfully reconstructed shapes obscured by 1-inch-thick foam. To the human eye, it’s like seeing through walls.
“A lot of imaging techniques make images look a little bit better, a little bit less noisy, but this is really something where we make the invisible visible,” said Gordon Wetzstein, assistant professor of electrical engineering at Stanford and senior author of the paper. “This is really pushing the frontier of what may be possible with any kind of sensing system. It’s like superhuman vision.”
This technique complements other vision systems that can see through barriers on the microscopic scale —for applications in medicine—because it’s more focused on large-scale situations, such as navigating self-driving cars in fog or heavy rain and satellite imaging of the surface of Earth and other planets through hazy atmosphere.
Salk study is the first to reveal ways cells from the human circulatory system change with age and age-related diseases.
Salk scientists have used skin cells called fibroblasts from young and old patients to successfully create blood vessels cells that retain their molecular markers of age. The team’s approach, described in the journal eLife on September 8, 2020, revealed clues as to why blood vessels tend to become leaky and hardened with aging, and lets researchers identify new molecular targets to potentially slow aging in vascular cells.
“The vasculature is extremely important for aging but its impact has been underestimated because it has been difficult to study how these cells age,” says Martin Hetzer, the paper’s senior author and Salk’s vice president and chief science officer.
Aiming to make deciding where to travel a bit easier, as COVID-19 continues to spark restrictions and rules for traveling around the United States, United Airlines created an interactive, color-coded map detailing everything travelers need to know ahead of planning a trip.
The map lists everything from whether or not entry into a state is allowed, potential quarantine measures, testing requirements, and even mask mandates for all 50 states and Washington D.C., the company shared with Travel + Leisure. Travelers can see if restaurants, tourist sites, or hotels are open and if there are any specific restrictions in place.
“We know it’s a challenge to keep up with the ever-changing list of travel restrictions, policies and regulations so we are offering a simple, easy tool that helps customers decide where to travel next,” Linda Jojo, the executive vice president for technology and chief digital officer, said in a statement. “By providing the most up-to-date information on the destinations we serve, customers can compare and shop for travel with greater confidence and help them find the destinations that best fit their preferences.”
(Reuters) — Delivery fleet operators face regulatory pressure in California and other states to buy electric vehicles, but a surge in package deliveries thanks to coronavirus lockdowns has major firms itching to switch to electric right now.
William E. Halal, The TechCast Project, George Washington University
The coronavirus is a stark reminder of the devastating damage that could be inflicted by cyberattacks, superbugs, freak weather and a variety of other threats. These wild cards are in addition to the existential challenge posed by climate change, gross inequality, financial meltdowns, autocratic governments, terrorism and other massive problems collectively called the Global MegaCrisis.
I sense the world is so frightened by recent disasters that people are searching for new solutions. They seem ready to break from the past that is no longer working. Climate change is starting to bite, for instance, and there is a growing consensus that the status quo is no longer sustainable.
I have studied this dilemma for decades, and I think it can be best understood as a transition to the next stage of social evolution. The Knowledge Age that dominated the last two decades is fading into the past as AI automates knowledge, forcing us to move beyond knowledge and develop a global consciousness able to resolve the MegaCrisis.
Yes, I know this is a bold claim, but that is how the shift to a world of knowledge looked 40 years ago. When computers filled rooms, I recall telling people that we were entering a world of personal computers. The typical response was “Why would anyone want a personal computer?”
Just so, today’s post-factual era illustrates how the smart phone, social media, and autocrats like Trump have moved public attention beyond knowledge and into a world of values, emotions and beliefs. Now the challenge is to use these new powers of social media to shape a global consciousness, or face disaster. While this may seem impossible, that is always the case before major upheavals. Nobody thought the USSR would collapse up until its very end.
In fact, the Business Roundtable’s recent announcement that business should move beyond the bottom line to include the interests of all stakeholders is revolutionary. It has now been promulgated by the World Economic Forum and other influential bodies. The gravity of this change is such that business is now being told to help resolve the climate crisis. Larry Fink, who runs the biggest investment firm in the world (Black Rock), directed the companies he owns to help address climate costs in their operations; within days, many firms announced climate plans.
This historic shift in consciousness could make corporations models of cooperation for society at large. In short, I think the world is heading toward some type of historic shift in consciousness, a collective epiphany, a code of global ethics, a spiritual revolution, a political paradigm shift or a new mindset. Without a consciousness based on global unity, cooperation and other essential beliefs, there seems little hope. And with a shift to global consciousness, it all seems possible.
Toward a Global Consciousness
The governing ideas inherited from the industrial past are outdated and heading toward disaster. It is a collapse of today’s reigning “materialist” ideology of Capitalism, economic growth, money, power, self-interest, rationality, knowledge, etc. These values remain valid and useful, of course, but they are now badly limited. Prevailing practices in the US, as the most prominent example, are failing to address the climate crisis, low wage employee welfare, universal health care, women’s rights, political gridlock, aging infrastructure and other social issues that lie beyond sheer economics.
This could become a “Collapse of Capitalism” roughly equivalent to the “Collapse of Communism” in the 1990s, and it stems from the same fatal flaw – failure to adapt to a changing world. Communism could not meet the complex demands of the Information Revolution, and now Capitalism seems to be failing to adapt to a unified globe threatened by pandemics, climate change and the other threats making up the MegaCrisis.
The big question remaining is, “What should be the new vision, values, principles, and policies?” At the risk of appearing pedantic, I integrate what has been learned above and my forthcoming book, Beyond Knowledge, to outline five principles of what I consider “global consciousness.”
1. Treat the planet and all life forms as sacred. The Fermi Paradox notes that no other civilizations have been detected after decades of SETI searching. This rarity of life reminds us what a miracle plant Earth really is, and that we are responsible for its well-being.
2. Govern the world as a unified whole. Nations remain the major players in this global order, but they should be lightly governed by some type of global institution like the UN and other international bodies. Individuals should continue to be loyal to their nations and local institutions, but they should also accept their role as global citizens.
3. Collaborate With All Stakeholders. Free enterprise is the basis of society, and the good news is that business is on the verge of becoming cooperative. The Business Roundtable announcement that all stakeholders should be treated equally with investors seems an historic breakthrough. This move to a quasi-democratic form of enterprise could set a new standard for collaborative behavior and human values throughout modern societies. One of the benefits from a tragedy like this crisis may be a loss of faith in the status quo and an urge to cooperate. I see it everywhere, and it is a blessing in disguise emerging out of chaos.
4. Embrace diversity as an asset. Rather than becoming a uniform pallid bureaucracy, a unified world should embrace the wondrous diversity of cultures and individuals. Working across such differences poses a challenge, naturally, but differences are also a source of new knowledge, talents and human energy.
5. Celebrate Community. Any society needs frequent opportunities to gather together in good spirit, enjoy differences and commonalities, and to simply celebrate the glory of life. The World Olympics Games, for instance, are special because they provide a rare feeling of global community. We could witness a flowering of celebratory events over the coming years to nourish the global soul.
Shaping Consciousness
This is only one small study, of course, but I hope it provokes thinking toward a widely held vision for planet Earth at a time of crisis. An historic change in consciousness is hardly done overnight, and the obstacles posed by the status quo are formidable. But the Information Revolution provides a powerful method for shaping consciousness by using the Internet and public media. Think of the explosion of ideas, hatred and forbidden desires released by billions of people blasting into loudspeakers like Facebook and Twitter. Anybody can use the media to shape public opinion instantly, for better or worse.
The task we face is to shape a unified consciousness out of this morass of differences to solve the global crises that loom ahead. Today’s threats to reason is challenging us to counter wrongheaded beliefs and to provide more attractive visions, such as the principles for global consciousness outlined here. I suggest the place to begin is by discussing these ideas as widely as possible, and to shape public opinion roughly along these lines.
