Lifeboat Foundation

A five-month-old becomes the first person in England to get a drug with a list price of £1.79m.

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This sample tissue was anonymously donated from patients that have undergone surgery to treat epilepsy at the Massachusetts General Hospital in Boston (MGH). It was then given to researchers at Harvard’s Lichtman laboratory.

The Harvard researchers cut the tissue into ~5300 individual 30 nanometer sections using an automated tape collecting ultra-microtome, mounted those sections onto silicon wafers, and then imaged the brain tissue at 4 nm resolution in a customized 61-beam parallelized scanning electron microscope for rapid image acquisition.

Continue reading “Google helps map one cubic millimeter of human brain tissue” »

Mapping how humans move will help in future pandemics.

How people move around cities follows a predictable and universal pattern, scientist say, which will be crucial not only for urban planning but also controlling pandemics.

By analysing mobile-phone tracking data from across four continents, the team confirmed that people visit places more often when they don’t have to travel far to get there.

Continue reading “New universal law of human mobility” »

The coronavirus that causes COVID-19 can infect insulin-producing cells in the pancreas, reducing their ability to secrete insulin and sometimes causing cell death, a new study suggests.

Damaging these insulin-producing cells, known as beta cells, can potentially worsen symptoms of diabetes, particularly type 1 diabetes, wherein the pancreas already makes little to no insulin, according to the study authors. “If you imagine that there are some patients who already have diabetes, if the virus comes in and nails the remaining beta cells you have, that’s not good,” said co-senior author Peter Jackson, a professor in the department of microbiology and immunology at Stanford University School of Medicine.

Hydraulic Instability Decides Who’s to Die and Who’s to Live

In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic “corridor” and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.

In past studies, researchers have found that C. elegans gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrinks and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.

An international study led by UNSW researchers has mapped one of the most intact and complete dog genomes ever generated.

The genome sequence of the Basenji dog could have a big impact on the understanding of dog evolution, domestication and canine genetic diseases.

The Basenji—also known as the barkless dog—is an ancient African dog breed which still lives and hunts with tribesmen in the African Congo.

Picture yourself winning the lottery. A telltale pattern of brain activity can be seen on an MRI machine.

With 2700 locations across 10000 U.S. communities, YMCA is becoming a major hub for healthy living — From vaccinations and diabetes prevention programs, to healthy aging and wellness — Siva Balu, VP/Chief Information Officer — The Y of the U.S.A.

Mr. Siva Balu is Vice President and Chief Information Officer of YMCA of the U.S. (Y-USA), where he is working to rethink and reorganize the work of the organization’s information technology strategy to meet the changing needs of Y-USA and Ys throughout the country.

Continue reading “Siva Balu — VP / Chief Information Officer — YMCA of the U.S.A. — People, Potential, & Purpose” »

In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic “corridor” and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.

In past studies, researchers have found that C. elegans gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrink and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, have found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.

Prior studies revealed the genetic basis and biochemical signals that drive physiological cell death, but the mechanisms that select and initiate apoptosis in individual germ cells remained unclear. As germ cells mature along the gonad of the nematode, they first collectively grow in size and in volume homogenously. In the study just published in Nature Physics, the scientists show that this homogenous growth suddenly shifts to a heterogenous growth where some cells become bigger and some cells become smaller.