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With their AI approximation for psychedelic trips in place, the team says they can start to probe for similarities with how the human brain processes drugs, citing the structural similarity between neural nets and the human visual cortices.

“The process of generating natural images with deep neural networks can be perturbed in visually similar ways and may offer mechanistic insights into its biological counterpart — in addition to offering a tool to illustrate verbal reports of psychedelic experiences,” Schartner told PsyPost.

Lightweight VTOL Air Ambulances To Be Optimized For Emergency Response

Urban Aeronautics Ltd., a leading Israeli aerospace company, today announced it has reached an agreement to provide four CityHawk VTOL aircraft to Hatzolah Air for emergency medical service (EMS) applications.

In addition, Hatzolah Air will become Urban Aeronautics’ official sales representative and distribution channel to other EMS and rescue organizations worldwide. The companies previously signed an MOU to develop, produce, and market the CityHawk aircraft for EMS applications.

One mouse is hunched over, graying, and barely moves at 7 months old. Others, at 11 months, have sleek black coats and run around. The videos and other results from a new study have inspired hope for treating children born with progeria, a rare, fatal, genetic disease that causes symptoms much like early aging. In mice with a progeria-causing mutation, a cousin of the celebrated genome editor known as CRISPR corrected the DNA mistake, preventing the heart damage typical of the disease, a research team reports today in. Treated mice lived about 500 days, more than twice as long as untreated animals.

“The outcome is incredible,” says gene-therapy researcher Guangping Gao of the University of Massachusetts, who was not involved with the study.

Continue reading “‘Incredible’ gene-editing result in mice inspires plans to treat premature-aging syndrome in children” »

Summary: Heating up cancer cells as they are being targeted with chemotherapy appears to be a highly effective way of killing them off.

Source: UCL

The study, published in the Journal of Materials Chemistry B, found that “loading” a chemotherapy drug on to tiny magnetic particles that can heat up the cancer cells at the same time as delivering the drug to them was up to 34% more effective at destroying the cancer cells than the chemotherapy drug without added heat.

Has some interesting parts, might interest some.

(not sure how novel)

As human beings age, the functioning of organs gradually deteriorates. While countless past studies have investigated the effects of aging on the human body, brain and on cognition, the neural mechanisms and environmental factors that can accelerate or slow down these effects are not yet fully understood.

Continue reading “Study explores the effects of immune responses on the aging brain” »

Brown fat is that magical tissue that you would want more of. Unlike white fat, which stores calories, brown fat burns energy and scientists hope it may hold the key to new obesity treatments. But it has long been unclear whether people with ample brown fat truly enjoy better health. For one thing, it has been hard to even identify such individuals since brown fat is hidden deep inside the body.

Now, a new study in Nature Medicine offers strong evidence: among over 52000 participants, those who had detectable brown fat were less likely than their peers to suffer cardiac and metabolic conditions ranging from type 2 diabetes to coronary artery disease, which is the leading cause of death in the United States.

The study, by far the largest of its kind in humans, confirms and expands the health benefits of brown fat suggested by previous studies. “For the first time, it reveals a link to lower risk of certain conditions,” says Paul Cohen, the Albert Resnick, M.D., Assistant Professor and senior attending physician at The Rockefeller University Hospital. “These findings make us more confident about the potential of targeting brown fat for therapeutic benefit.”

The enormous impact of the recent COVID-19 pandemic, together with other diseases or chronic health risks, has significantly prompted the development and application of bioelectronics and medical devices for real-time monitoring and diagnosing health status. Among all these devices, smart contact lenses attract extensive interests due to their capability of directly monitoring physiological and ambient information. Smart contact lenses equipped with high sensitivity sensors would open the possibility of a non-invasive method to continuously detect biomarkers in tears. They could also be equipped with application-specific integrated circuit chips to further enrich their functionality to obtain, process and transmit physiological properties, manage illnesses and health risks, and finally promote health and wellbeing. Despite significant efforts, previous demonstrations still need multistep integration processes with limited detection sensitivity and mechanical biocompatibility.

Recently, researchers from the University of Surrey, National Physical Laboratory (NPL), Harvard University, University of Science and Technology of China, Zhejiang University Ningbo Research Institute, etc. have developed a multifunctional ultrathin contact lens sensor system. The sensor systems contain a photodetector for receiving optical information, imaging and vision assistance, a temperature sensor for diagnosing potential corneal disease, and a glucose sensor for monitoring glucose level directly from the tear fluid.

Dr. Yunlong Zhao, Lecturer in Energy Storage and Bioelectronics at the Advanced Technology Institute (ATI), University of Surrey and Senior Research Scientist at the UK National Physical Laboratory (NPL), who led this research stated, “These results provide not only a novel and easy-to-make method for manufacturing advanced smart contact lenses but also a novel insight of designing other multifunctional electronics for Internet of Things, human machine interface, etc.” Dr. Zhao added, “our ultrathin transistors-based serpentine mesh sensor system and fabrication strategy allow for further incorporation of other functional components, such as electrode array for electrophysiology, antennas for wireless communication, and the power modules, e.g. thin-film batteries and enzymatic biofuel cell for future in vivo exploration and practical application. Our research team at ATI, University of Surrey and NPL are currently working on these fields.”

For an equitable end to the pandemic, the world needs vaccines that can safely reach rural and remote areas.

When taken orally or intravenously, medications typically travel throughout the body, producing unwanted side effects. MIT scientists are working on an alternative, that delivers both light and a light-activated drug directly to the target area.

So-called “photoswitchable” drugs contain light-sensitive molecules that essentially switch the drug on when exposed to a flash of light. This means that a pharmaceutical could remain inactive when moving through the bloodstream or digestive tract, only becoming active once it reached the place it was needed. As a result, few if any side effects would occur.

That said, how could a flash of light be delivered precisely to the target area, right when the drug was present at that location? Well, that’s where a device developed by the MIT researchers comes into play.