Lifeboat Foundation

When taken orally or intravenously, medications typically travel throughout the body, producing unwanted side effects. MIT scientists are working on an alternative, that delivers both light and a light-activated drug directly to the target area.

So-called “photoswitchable” drugs contain light-sensitive molecules that essentially switch the drug on when exposed to a flash of light. This means that a pharmaceutical could remain inactive when moving through the bloodstream or digestive tract, only becoming active once it reached the place it was needed. As a result, few if any side effects would occur.

That said, how could a flash of light be delivered precisely to the target area, right when the drug was present at that location? Well, that’s where a device developed by the MIT researchers comes into play.

Scientists have developed a machine-learning method that crunches massive amounts of data to help determine which existing medications could improve outcomes in diseases for which they are not prescribed.

The intent of this work is to speed up drug repurposing, which is not a new concept—think Botox injections, first approved to treat crossed eyes and now a migraine treatment and top cosmetic strategy to reduce the appearance of wrinkles.

But getting to those new uses typically involves a mix of serendipity and time-consuming and expensive randomized clinical trials to ensure that a drug deemed effective for one disorder will be useful as a treatment for something else.

Proteins are essential to cells, carrying out complex tasks and catalyzing chemical reactions. Scientists and engineers have long sought to harness this power by designing artificial proteins that can perform new tasks, like treat disease, capture carbon or harvest energy, but many of the processes designed to create such proteins are slow and complex, with a high failure rate.

In a breakthrough that could have implications across the healthcare, agriculture, and energy sectors, a team lead by researchers in the Pritzker School of Molecular Engineering at the University of Chicago has developed an artificial intelligence-led process that uses big data to design new proteins.

By developing machine-learning models that can review protein information culled from genome databases, the researchers found relatively simple design rules for building artificial proteins. When the team constructed these artificial proteins in the lab, they found that they performed chemical processes so well that they rivaled those found in nature.

Polymers could be used to create less expensive gene therapies or vaccines for diseases.

The world is far from perfect, and 2020 did throw the proverbial spanner is the works, but the improvements we have made are not to be ignored!!

We are winning…

Continue reading “The Sustainable Development Goals Explained Clean Water And Sanitation” »

SANTIAGO (Reuters) — The coronavirus has landed in Antarctica, the last continent previously free from COVID-19, Chile’s military said this week, as health and army officials scrambled to clear out and quarantine staff from a remote research station surrounded by ocean and icebergs.

We think our approach — which is backed up by several techniques, including single-cell RNA-sequencing analysis — is a significant step toward bringing SSC therapy into the clinic, Miles Wilkinson, an obstetrics, gynecology, and reproductive sciences researcher at the University of California, San Diego School of Medicine, said in a press release.

SSCs can generate more stem cells and as many as 1, 000 sperm every couple of seconds — but until this new study, published Monday in the journal PNAS, scientists were unable to differentiate and isolate SSCs from other, similar cells in the testicles.

Next, our main goal is to learn how to maintain and expand human SSCs longer so they might be clinically useful, Wilkinson said in the release.

Unmanned Aerial Vehicles (UAV), commonly referred to as drones, may prove to be a valuable tool in the battle against pandemics like COVID-19. Researchers at the University of Calgary, the Southern Alberta Institute of Technology (SAIT), Alberta Health Services (AHS) and Alberta Precision Laboratories (APL) are partnering with the Stoney Nakoda Nations (SNN) to deliver medical equipment and test kits for COVID-19 to remote areas, and to connect these communities to laboratories more quickly using these remotely piloted aircraft.

Access for all

“We know that testing for COVID-19 is one of our most effective tools against its spread. Many remote communities in Canada do not have easy access to testing centres and medical supplies to support rapid testing and containment. Drones can help us respond to that need,” says Dr. John Conly, MD, medical director of the W21C Research and Innovation Centre at the Cumming School of Medicine (CSM) and co-principal investigator on the project.

Bats are the second most diverse mammalian group, playing keystone roles in ecosystems but also act as reservoir hosts for numerous pathogens. Due to their colonial habits which implies close contacts between individuals, bats are often parasitized by multiple species of micro-and macroparasites. The particular ecology, behavior, and environment of bat species may shape patterns of intra-and interspecific pathogen transmission, as well as the presence of specific vectorial organisms. This review synthetizes information on a multi-level parasitic system: bats, bat flies and their microparasites. Bat flies (Diptera: Nycteribiidae and Streblidae) are obligate, hematophagous ectoparasites of bats consisting of ~500 described species. Diverse parasitic organisms have been detected in bat flies including bacteria, blood parasites, fungi, and viruses, which suggest their vectorial potential. We discuss the ecological epidemiology of microparasites, their potential physiological effects on both bats and bat flies, and potential research perspectives in the domain of bat pathogens. For simplicity, we use the term microparasite throughout this review, yet it remains unclear whether some bacteria are parasites or symbionts of their bat fly hosts.

Bats are the second most diverse mammalian group after rodents, with ~1390 recognized species across 227 genera (1). Many bat species play keystone roles in ecosystems, where they are essential to pollination, seed dispersal, and pest control (2). Several studies have also highlighted their prominent role as pathogen-reservoirs (3, 4); viruses being the best studied due to their potential as human pathogens (3, 5 – 8). Bats host more viruses per species than rodents, making them an interesting system for both disease ecology and public health research (4, 9).

Bacteria (such as Bartonella spp. and Borrelia spp.) and protozoans (such as Trypanosoma spp. and Plasmodium spp.) have also been detected in bats (8, 10, 11). In recent years, bat-associated Bartonella genotypes have been found in humans, indicating the public health importance of this parasite in bats (12 – 14). Bartonella and other pathogen transmission from bats to humans may occur through religious activities in caves, bat consumption or contact with contaminated products (12, 15). There are documented cases of bat-specific ectoparasites biting humans (16, 17), increasing the potential of bat-born pathogen transmission. Additionally, bat-associated pathogen, such as Trypanosoma cruzi genotype has also been found in humans (18).