Lifeboat Foundation

A new book from Steve Jobs biographer Walter Isaacson offers an incisive portrait of the gene editing field that is changing modern medicine.

Rapamycin is the drug used to suppress the immune system after organ transplants, but in reduced doses, it appears it may have other health benefits and as such is discussed considerably in the longevity community, and taken regularly my some very famous proponents.

So I thought I would give you some background, alongside the pros and cons, to see what all the fuss is about…

Continue reading “Rapamycin Anti Aging — Worth The Hype?” »

North Carolina State University engineers continue to improve the efficiency of a flexible device worn on the wrist that harvests heat energy from the human body to monitor health.

In a paper published in npj Flexible Electronics, the NC State researchers report significant enhancements in preventing heat leakage in the flexible body heat harvester they first reported in 2017 and updated in 2020. The harvesters use heat energy from the human body to power wearable technologies —think of smart watches that measure your heart rate, blood oxygen, glucose and other health parameters—that never need to have their batteries recharged. The technology relies on the same principles governing rigid thermoelectric harvesters that convert heat to electrical energy.

Flexible harvesters that conform to the human body are highly desired for use with wearable technologies. Mehmet Ozturk, an NC State professor of electrical and computer engineering and the corresponding author of the paper, mentioned superior skin contact with flexible devices, as well as the ergonomic and comfort considerations to the device wearer, as the core reasons behind building flexible thermoelectric generators, or TEGs.

Non-rigid point set registration is the process of finding a spatial transformation that aligns two shapes represented as a set of data points. It has extensive applications in areas such as autonomous driving, medical imaging, and robotic manipulation. Now, a method has been developed to speed up this procedure.

In a study published in IEEE Transactions on Pattern Analysis and Machine Intelligence, a researcher from Kanazawa University has demonstrated a technique that reduces the computing time for non-rigid point set registration relative to other approaches.

Previous methods to accelerate this process have been computationally efficient only for shapes described by small point sets (containing fewer than 100000 points). Consequently, the use of such approaches in applications has been limited. This latest research aimed to address this drawback.

You’ve heard of animals that can lose and then regenerate a tail or limb. But scientists reporting in the journal Current Biology on March 8 have now discovered two species of sacoglossan sea slug that can do even better, shedding and then regenerating a whole new body complete with the heart and other internal organs. The researchers also suggest that the slugs may use the photosynthetic ability of chloroplasts they incorporate from the algae in their diet to survive long enough for regeneration.

“We were surprised to see the head moving just after autotomy,” said Sayaka Mitoh of Nara Women’s University in Japan. “We thought that it would die soon without a heart and other important organs, but we were surprised again to find that it regenerated the whole body.”

Continue reading “These sea slugs sever their own heads and regenerate brand-new bodies” »

Nanoengineers at the University of California San Diego have developed a “wearable microgrid” that harvests and stores energy from the human body to power small electronics. It consists of three main parts: sweat-powered biofuel cells, motion-powered devices called triboelectric generators, and energy-storing supercapacitors. All parts are flexible, washable and can be screen printed onto clothing.

The technology, reported in a paper published Mar. 9 in Nature Communications, draws inspiration from community microgrids.

“We’re applying the concept of the microgrid to create wearable systems that are powered sustainably, reliably and independently,” said co-first author Lu Yin, a nanoengineering Ph.D. student at the UC San Diego Jacobs School of Engineering. “Just like a city microgrid integrates a variety of local, renewable power sources like wind and solar, a wearable microgrid integrates devices that locally harvest energy from different parts of the body, like sweat and movement, while containing energy storage.”

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

Now, in the first study of its kind, Cheryl Nickerson, lead author Jennifer Barrila and their colleagues describe the infection of human cells by the intestinal pathogen Salmonella Typhimurium during spaceflight. They show how the microgravity environment of spaceflight changes the molecular profile of human intestinal cells and how these expression patterns are further changed in response to infection. In another first, the researchers were also able to detect molecular changes in the bacterial pathogen while inside the infected host cells.

The results offer fresh insights into the infection process and may lead to novel methods for combatting invasive pathogens during spaceflight and under less exotic conditions here on earth.

Materials capable of performing complex functions in response to changes in the environment could form the basis for exciting new technologies. Think of a capsule implanted in your body that automatically releases antibodies in response to a virus, a surface that releases an antibacterial agent when exposed to dangerous bacteria, a material that adapts its shape when it needs to sustain a particular weight, or clothing that senses and captures toxic contaminants from the air.

Scientists and engineers have already taken the first step toward these types of autonomous materials by developing “active” materials that have the ability to move on their own. Now, researchers at the University of Chicago have taken the next step by showing that the movement in one such active material—liquid crystals—can be harnessed and directed.

This proof-of-concept research, published on February 182021, in the journal Nature Materials, is the result of three years of collaborative work by the groups of Juan de Pablo, Liew Family Professor of Molecular Engineering, and Margaret Gardel, Horace B. Horton Professor of Physics and Molecular Engineering, along with Vincenzo Vitelli, professor of physics, and Aaron Dinner, professor of chemistry.

Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published on March 22021, in Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.

Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules — called sulfated glycosaminoglycans — that are often used as drugs and nutraceuticals…

“It’s a challenge to engineer E. coli to produce these molecules, and we had to make many changes and balance those changes so that the bacteria will grow well,” said Mattheos Koffas, lead researcher and a professor of chemical and biological engineering at Rensselaer Polytechnic Institute. “But this work shows that it is possible to produce these polysaccharides using E. coli in animal-free fashion, and the procedure can be extended to produce other sulfated glycosaminoglycans.”