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Category: biotech/medical – Page 1,346

How tardigrades come back from the dead

Year 2017 Basically the tardigrade is the most promising set of genes on any creature due to many types of survival genes like going years without food or even genes for radiation resistance which could be used in crispr to augment human genes.

Tardigrades — aka water bears or moss piglets — are perhaps the most resilient creatures on the planet, able to survive complete dehydration, space vacuum and being frozen. However, only recently have scientists begun to unravel the genes that underpin the tardigrade’s biological superpowers. “They’re 0.2mm to 1mm in length and despite being so small they are able to do all these things we cannot,” says Mark Blaxter, a biologist at the University of Edinburgh who has been studying tardigrades for 20 years. “In their DNA, they hold a cornucopia of secrets.”

With Kazurahu Arakawa, from the University of Keio, Japan, Blaxter recently analysed the first true tardigrade genome. The results, published today in the open access journal PLOS Biology, are a first step towards explaining the genetics underpinning the tardigrade’s extraordinary resilience and to pinpoint its place within the evolutionary tree of life. We spoke to Blaxter about his new research and his fascination for this remarkable little animal.

**WIRED:**How come we are only now able to analyse the tardigrade’s true genomes?

Thousands of phages found to have CRISPR gene editing system

A team of researchers at the University of California, Berkeley, and University of California, Los Angeles, working with a colleague from Vilnius University, has found evidence of thousands of phages with DNA strands that should allow them to conduct gene editing on other viruses or bacteria. Their paper has been published in the open-access journal Cell.

In 2012, some of the researchers on this same team discovered that CRISPR-Cas9 could be programmed using RNA to edit targeted DNA strands from other organisms (and won a Nobel prize for it). Their work emerged from findings that many types of use CRISPR-Cas systems to defend against viral attacks. Using such systems, bacteria can cut and remove strands of DNA from and store them in their own genomes to combat the same viral strain should it attack again.

Since that time, researchers have found that some viruses have similar machinery, but it was deemed to be rare. In this new effort, the researchers sought to determine actual prevalence.

What Happens When Everyone Realises We Can Live Much Longer? We May Find Out As Soon As 2025

Let’s not just cure cancer: let’s cure aging One of the most exciting areas of modern scientific research is the investigation of the causes and cures for aging. Not individual diseases like cancer and heart disease, but the processes which make us elderly and frail, and which thereby make us more susceptible to these diseases.

Researchers discover new form of antimicrobial resistance

Australian researchers have uncovered a new form of antimicrobial resistance (AMR), undetectable using traditional laboratory testing methods, in a discovery set to challenge existing efforts to monitor and tackle one of the world’s greatest health threats.

AMR is expected to claim 10 million lives a year by 2050, with scientists racing to understand and get ahead of the diminishing benefits of antibiotics.

Now, a team led by Dr. Timothy Barnett, Head of the Strep A Pathogenesis and Diagnostics team at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at Telethon Kids Institute in Perth, Western Australia, has unearthed a critical clue to the way some bacteria are managing to dodge antibiotics—a finding expected to be the tip of the iceberg.

Dr Katcher’s E5 Experiment November 2022 Update

Short version: One treated rat is sill alive and equivalent to a 110 year old human.

In this video we review the latest updates from Dr Katcher’s Lifespan trials and NEEL clinical trials.
NTZ Newsletter.
https://www.ntzplural.com/newsletter.
NEEL website.
https://www.neel.bio.

Renue By Science 10% of all products: https://tinyurl.com/4yrf4tv3

10% off DoNotAge all products with discount code MODERNHEALTHSPAN
https://donotage.org/products/

10% Discount off all ProHealth longevity products: https://tinyurl.com/269hzbt7

Continue reading “Dr Katcher’s E5 Experiment November 2022 Update” | >

Can ‘Blueprint’ make you biologically younger?

If you enjoyed this video, you might like my book: https://ageless.link/

I saw a Twitter thread about Bryan Johnson’s ‘Blueprint’, claiming that he’d made himself biologically younger with a highly optimised combination of diet, supplements and exercise. What could that mean? And should we all start chugging 25 pills a day to start on the Blueprint ourselves? Probably not…but the biology behind it is surprisingly interesting.

*Chapters*

00:00 A tweet goes viral.
00:44 Getting ‘biologically younger’
01:23 NAD levels.
03:09 Maximum heart rate.
04:12 Epigenetic clocks.
07:12 Step 1: the Blueprint diet.
09:23 Step 2: ALL THE SUPPLEMENTS
11:43 Step 3: track progress.
12:40 Conclusion.

*Sources and further reading*

My book, Ageless: The new science of getting older without getting old, goes into far more depth about rapamycin, metformin and epigenetic clocks, and lots more! https://ageless.link/

Continue reading “Can ‘Blueprint’ make you biologically younger?” | >

New study maps the development of the 20 most common psychiatric disorders

“Let’s see how things go.”

So psychiatrists often say to one another after a patient has been diagnosed with the first disorder—not because the diagnosis is not correct, but because psychiatrists know that have a tendency to change over the years.

In fact, 47% of psychiatric patients are diagnosed with a different diagnose within 10 years of receiving their first diagnosis.

New small molecule drug for lowering cholesterol

After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are available as oral agents, PCSK9 inhibitors can only be administered as injections, creating barriers to their use.

Longevity. Technology: Having high cholesterol can increase the risk of heart and circulatory diseases such as heart attack, stroke and vascular dementia, but a new study from investigators at University Hospitals (UH) and Case Western Reserve University School of Medicine details an orally administered small-molecule drug that reduces PCSK9 levels and lowers cholesterol in animal models by 70%. Published in Cell Reports, the findings represent a previously unrecognised strategy for managing cholesterol and may also impact cancer treatments.

Cardiovascular disease ranking as the world’s number one killer, so it’s no surprise that a significant amount of research into potential therapeutic options is ongoing; just last week we looked at Cyclarity’s rationally-designed cyclodextrin molecules that remove arterial plaque by clearing the non-degradable oxidised cholesterol and which can be used in conjunction with statins for a broad-spectrum approach. Our report into Cyclarity’s new platform comes out next week, so stay tuned!

N, N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats

Year 2020 Stroke victims could eventually get dmt infusions where they can recover quickly after a stroke.

N, N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain.

Transient middle cerebral occlusion (MCAO) was induced for 60 min in male Wistar rats using the filament occlusion model under general anaesthesia. Before the removal of the filament the treatment group (n = 10) received an intra-peritoneal (IP) bolus of 1 mg/kg-body weight (bw) DMT dissolved in 1 ml 7% ethanol/saline vehicle, followed by a maintenance dose of 2 mg/Kg-bw/h delivered over 24 h via osmotic minipumps. Controls (n = 10) received a vehicle bolus only. A third group (n = 10) received a Sig-1R antagonist (BD1063, 1 mg/kg-bw bolus +2 mg/kg-bw/h maintenance) in parallel with the DMT. Lesion volume was measured by MRI 24 h following the MCAO. Shortly after imaging the animals were terminated, and the native brains and sera were removed. Four rats were perfusion fixed. Functional recovery was studied in two separate group of pre-trained animals (n = 8–8) using the staircase method for 30 days.

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