Circa 2018
CRISPR will realize its potential in plastic and reconstructive surgery only if plastic surgeons gain familiarity with this disruptive technology and become active contributors and leaders in applying CRISPR to their respective areas of expertise.
Circa 2020
Self-propelling magnetic nanorobots capable of intrinsic-navigation in biological fluids with enhanced pharmacokinetics and deeper tissue penetration implicates promising strategy in targeted cancer therapy. Here, multi-component magnetic nanobot designed by chemically conjugating magnetic Fe3O4 nanoparticles (NPs), anti-epithelial cell adhesion molecule antibody (anti-EpCAM mAb) to multi-walled carbon nanotubes (CNT) loaded with an anticancer drug, doxorubicin hydrochloride (DOX) is reported. Autonomous propulsion of the nanobots and their external magnetic guidance is enabled by enriching Fe3O4 NPs with dual catalytic-magnetic functionality. The nanobots propel at high velocities even in complex biological fluids. In addition, the nanobots preferably release DOX in the intracellular lysosomal compartment of human colorectal carcinoma (HCT116) cells by the opening of Fe3O4 NP gate.
Circa 2017 using this can lead to near Ironman or foglet bodies with the ability to self heal the human body. It could be used on smartphones to heal people not needing a doctor in the future. This also would allow for the biological singularity to happen.
This device shoots new genetic code into cells to make them change their purpose. Researchers say the chip could someday be used to treat injuries in humans. But they’ve got a long, long way to go.
A once forgotten technology, RNA editing has been gaining traction as a treatment for genetic conditions given its key advantages over CRISPR gene editing.
Since CRISPR-Cas9 gene editing was first reported in 2012, its promise of making gene editing faster, cheaper, and easier than ever before led to an explosion in the number of publications referring to this gene editing technology.
An increasing number of research labs and companies are aiming to translate CRISPR gene editing into therapies for genetic diseases. However, further research has unveiled that there are more limitations to using CRISPR-Cas9 to cure diseases than initially expected. For example, the technology has been reported to introduce off-target changes to the DNA, raising concerns about its safety.
Novel study designed to correct genetic abnormalities of red blood cells.
Cleveland Clinic researchers are enrolling patients in a clinical trial that aims to work toward a cure for sickle cell disease, by changing the patient’s genetics. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
The multicenter study will evaluate the safety and effectiveness of a single dose of EDIT-301, an experimental one-time gene editing cell therapy that modifies a patient’s own blood-forming stem cells to correct the mutation responsible for sickle cell disease.
Continue reading “Cleveland Clinic Trial to Test Gene Therapy as Treatment of Sickle Cell Disease” »
The U.S. Space Development Agency has five satellites riding on SpaceX’s Transporter-2 mission scheduled to launch June 25.
WASHINGTON — The U.S. Space Development Agency has five satellites riding on SpaceX’s Transporter-2 rideshare mission scheduled to launch June 25.
“There’s nothing in the space business that gets your blood pumping like the idea of a launch, especially if you’ve got multiple satellites,” a senior Space Development Agency (SDA) official told reporters June 22. “We’re really excited about what’s going to happen.”
Continue reading “Space Development Agency to launch five satellites aboard SpaceX rideshare” »
Some researchers suspect these bacterial ancestors living within our cells may contribute to a wide range of neurological and psychiatric disorders.
By Diana Kwon.
Continue reading “Could mitochondria be the key to a healthy brain?” »
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Researchers from the New York University School of Medicine have developed a brain implant designed to detect pain sensations in real-time and deliver bursts of pain-relieving stimulation. The device is still deeply experimental but a new proof of concept study demonstrates it working effectively in rodent models.
In the world of brain implants the chasm between science fiction and reality is still quite vast. Apart from some exciting human tests showing paralyzed individuals with implants regaining a sense of touch or controlling computers with their mind, most research in the field is still nascent.
Animal tests have demonstrated incremental technological advances, such as pigs broadcasting neural activity or monkeys playing Pong. Now, an interface that can detect pain signals in one part of the brain and immediately respond with stimulation to another part of the brain targeted to relieve that pain has been developed.
Biologists in the UK and Austria have discovered 71 new imprinted genes in the mouse genome.
Biologists at the Universities of Bath and Vienna have discovered 71 new ‘imprinted’ genes in the mouse genome, a finding that takes them a step closer to unraveling some of the mysteries of epigenetics – an area of science that describes how genes are switched on (and off) in different cells at different stages in development and adulthood.
To understand the importance of imprinted genes to inheritance, we need to step back and ask how inheritance works in general. Most of the thirty trillion cells in a person’s body contain genes that come from both their mother and father, with each parent contributing one version of each gene. The unique combination of genes goes part of the way to making an individual unique. Usually, each gene in a pair is equally active or inactive in a given cell. This is not the case for imprinted genes. These genes – which make up less than one percent of the total of 20000+ genes – tend to be more active (sometimes much more active) in one parental version than the other.
