Benjamin Wallace-Wells writes about a growing consensus among researchers that the pathogen that gave rise to the COVID-19 pandemic may have emerged from a laboratory in Wuhan, China, rather than through a natural migration from animals to humans.
Things to note: Treating the rats until they die. They are at 31 months and the longest they have lived without treatments is 38 months. Also, a small number of people have done this and though ailments like arthritis go away they still look elderly.
We recently had an update from Professor Rodolfo Goya who is conducting a follow up experiment from the one that Dr. Katcher first did in India, showing a rejuvenation in old rats. This video goes through the update that we had and provides a short introduction to the background.
Rift Valley fever used to mostly affect livestock in Africa. But the virus that causes it is also spread by mosquitoes whose habitats are expanding because of climate change. If it were to make its way to the rest of the world, it would decimate livestock causing agricultural collapse as well as affecting human health.
In 2015 the Zika virus triggered a global health crisis that left thousands of parents devastated. The virus can cause serious problems in pregnancy, leading to babies with birth defects called microcephaly and other neurological problems. But Zika is not the only virus that can be devastating to pregnant women and their babies; there is another with pandemic potential that could be even more deadly – Rift Valley fever.
The placenta that encases the baby acts as a fortress against many pathogens, but a few can evade its defences. Rift Valley fever is one of them – a 2019 study shows that the virus has the ability to infect a specialised layer of placental cells that carry nutrients to the baby, something that even Zika may not be capable of. In cattle and other livestock, in which the virus spreads, infection can cause more than 90% of pregnant cows to miscarry or deliver stillborn calves. Although the virus kills fewer than 1% of people it infects, it is the risk to babies, and the lasting neurological effects in adults, that is of great concern.
It would be nice if they listed their diet.
Summary: Simple dietary changes and adopting lifestyle alterations, including improved sleep schedules, taking probiotics, and exercising, can reduce signs of biological aging by three years in just eight weeks, a new study reports.
Source: Impact Journals
Continue reading “Diet and Lifestyle Change Reverses Aging” »
One hundred fifty years ago, Dmitri Mendeleev created the periodic table, a system for classifying atoms based on the properties of their nuclei. This week, a team of biologists studying the tree of life has unveiled a new classification system for cell nuclei and discovered a method for transmuting one type of cell nucleus into another.
The study, which appears this week in the journal Science, emerged from several once-separate efforts. One of these centered on the DNA Zoo, an international consortium spanning dozens of institutions including Baylor College of Medicine, the National Science Foundation-supported Center for Theoretical Biological Physics (CTBP) at Rice University, the University of Western Australia and SeaWorld.
Scientists on the DNA Zoo team had been working together to classify how chromosomes, which can be several meters long, fold up to fit inside the nuclei of different species from across the tree of life.
More on thymus regeneration. Unless I understood wrong one patient’s epigenetic clock went from his mid 50’s to early 40’s.
Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Continue reading “Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update” »
Circa 2016
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism.
In normal individuals, food intake and energy expenditure are tightly regulated by homeostatic mechanisms to maintain energy balance. Substantial evidence indicates that the brain, particularly the hypothalamus, is primarily responsible for the regulation of energy homeostasis.1 The brain monitors changes in the body energy state by sensing alterations in the plasma levels of key metabolic hormones and nutrients. Specialized neuronal networks in the brain coordinate adaptive changes in food intake and energy expenditure in response to altered metabolic conditions ( Figure 1 ).2, 3.
For the first time, researchers have successfully sequenced the entire genome from the skull of Peştera Muierii 1, a woman who lived in today’s Romania 35000 years ago. Her high genetic diversity shows that the out of Africa migration was not the great bottleneck in human development but rather this occurred during and after the most recent Ice Age. This is the finding of a new study led by Mattias Jakobsson at Uppsala University and being published in Current Biology.
“She is a bit more like modern-day Europeans than the individuals in Europe 5000 years earlier, but the difference is much less than we had thought. We can see that she is not a direct ancestor of modern Europeans, but she is a predecessor of the hunter-gathers that lived in Europe until the end of the last Ice Age,” says Mattias Jakobsson, professor at the Department of Organismal Biology at Uppsala University and the head of the study.
Very few complete genomes older than 30000 years have been sequenced. Now that the research team can read the entire genome from Peştera Muierii 1 (see the fact box below), they can see similarities with modern humans in Europe while also seeing that she is not a direct ancestor. In previous studies, other researchers observed that the shape of her cranium has similarities with both modern humans and Neanderthals. For this reason, they assumed that she had a greater fraction of Neanderthal ancestry than other contemporaries, making her stand out from the norm. But the genetic analysis in the current study shows that she has the same low level of Neanderthal DNA as most other individuals living in her time. Compared with the remains from some individuals who lived 5000 years earlier, such as Peştera Oase 1, she had only half as much Neanderthal ancestry.
“It’s a wake-up call that one-year-old children are already carrying gut bacteria that are resistant to very important types of antibiotics. New resistant bacteria are becoming more widespread due to increased antibiotic consumption. The horror scenario is that we will one day lack the antibiotics needed to treat life-threatening bacterial infections such as pneumonia or foodborne illnesses,” explains Department of Biology professor Søren Sørensen, who led the study.
Danish one-year-olds carry several hundred antibiotic resistant genes in their bacterial gut flora according to a new study from the University of Copenhagen. The presence of these genes is partly attributable to antibiotic use among mothers during pregnancy.
An estimated 700000 people die every year from antibiotic resistant bacterial infections and diseases. The WHO expects this figure to multiply greatly in coming decades. To study how antibiotic resistance occurs in humans’ natural bacterial flora, researchers from the University of Copenhagen’s Department of Biology analyzed stool samples from 662 Danish one-year-old children.
Innovating At The Frontiers Of Cancer Biology — Dr. Jonathan Chernoff MD, PhD, Senior Vice President, Deputy Director, and Chief Scientific Officer, Fox Chase Cancer Center.
Dr. Jonathan Chernoff, MD, PhD, is Senior Vice President, Deputy Director, and Chief Scientific Officer, at Fox Chase Cancer Center (https://www.foxchase.org/) where he coordinates and charts the future course of research for the organization.
