Lifeboat Foundation

Nuclear Pore Complexes and Genome Integrity — Dr. Veronica Rodriguez-Bravo Ph.D., Sidney Kimmel Cancer Center — Jefferson Health, Thomas Jefferson University.

Dr. Veronica Rodriguez-Bravo, PhD, is Assistant Professor, Department of Cancer Biology, at the Sidney Kimmel Cancer Center, Thomas Jefferson University, in Philadelphia, PA, USA. (https://sidneykimmelcancercenter.jeffersonhealth.org/)

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“Cannabis may contribute to increased risk for mental disorders, which has actually been shown in schizophrenia,” Penzes said. “Conversely, cannabis could be beneficial in some brain disorders, which prompted trials of medical marijuana in patients with autism.”

Summary: Findings reveal a role the endocannabinoid system plays in a range of psychiatric disorders, including schizophrenia, bipolar disorder, and ASD.

Source: Northwestern University

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Indiana University School of Medicine researchers are developing a new, noninvasive brain stimulation technique to treat neurological disorders, including pain, traumatic brain injury (TBI), epilepsy, Parkinson’s disease, Alzheimer’s disease and more.

“Given the increasing use of brain stimulation in human brain study and treatment of neurological diseases, this research can make a big impact on physicians and their patients,” said Xiaoming Jin, Ph.D., associate professor of anatomy, cell biology and physiology.

When someone experiences a brain injury, nerve injury, or neurodegeneration, such as in epilepsy and TBI, there is damage to the brain which can lead to loss and damage of nerve or neurons and development of hyperexcitability that underlies some neurological disorders such as neuropathic pain and epilepsy.

Researchers from Harvard University and the Massachusetts Institute of Technology, both based in Cambridge, Mass., have created small diagnostic biosensors that can be inserted into face masks and can diagnose COVID-19 within 90 minutes, The Mercury News reported June 29.

The insertable biosensors detect the virus from a wearer’s breath, producing easy to read results similar to those of an at-home pregnancy test. If the coronavirus is present, the system changes the pattern of lines in the readout strip.

To activate the test, the wearer pushes a button on the mask to release a small amount of water into the system, which activates the test.

Stem cells for teeth repair.

Teeth exhibit limited repair in response to damage, and dental pulp stem cells probably provide a source of cells to replace those damaged and to facilitate repair. Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development. Dental stem cells can be obtained with ease, making them an attractive source of autologous stem cells for use in restoring vital pulp tissue removed because of infection, in regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants. As dental stem cells share properties with mesenchymal stem cells, there is also considerable interest in their wider potential to treat disorders involving mesenchymal (or indeed non-mesenchymal) cell derivatives, such as in Parkinson’s disease.

Teeth are complex organs containing two separate specialized hard tissues, dentine and enamel, which form an integrated attachment complex with bone via a specialized (periodontal) ligament. Embryologically, teeth are ectodermal organs that form from sequential reciprocal interactions between oral epithelial cells (ectoderm) and cranial neural crest derived mesenchymal cells. The epithelial cells give rise to enamel forming ameloblasts, and the mesenchymal cells form all other differentiated cells (e.g., dentine forming odontoblasts, pulp, periodontal ligament) (Box 1). Teeth continue developing postnatally; the outer covering of enamel gradually becomes harder, and root formation, which is essential for tooth function, only starts to occur as part of tooth eruption in children.

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Joseph Bentley, 22, hopes the REACT device will save “hundreds of lives a year”.

The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.

In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU

Continue reading “Translating Blood Plasma Dilution To Humans | Drs. Irina & Mike Conboy Interrview Series Ep3” »

Did you know that life extension is impossible? I didn’t until the keen minds over at the Guardian informed me as such. Fortunately before I decided to give up my career in regenerative medicine I decided to look into exactly how the Guardian came to such a revelation. What I discovered was so earth shattering that it rocked my very understanding of the world, and made me question everything I thought I knew. That realisation was that, despite their consistent insistence to the contrary, the media lies, a lot.

Ok maybe this was not as shocking as I made it out to be, in fact it’s pretty widely known by now that the media is generally no stranger to the odd lie here and there. If you are not familiar with the story allow me to give you a recap. A recent study was conducted in order to find out if human lifespans have actually increased due to advanced in medicine. To do this, scientists used statistical models to remove non-age related causes of death from historical records (such as murder, death in child birth, plague etc) in order to determine what the uninterrupted human lifespan is, and if it has increased over time. What was found is that our medical science is yet to fundamentally extend human lifespan. This comes as no surprise to anyone in the field of longevity research as we know full well that none of our current medical treatments address causes of ageing. What this study does not conclude however is that life extension is impossible.

It appears your susceptibility to a virus, and also the intensity of the viral load that goes on to attack if your defences are breached, are inextricably linked to your sleep quality and circadian clock.