Lifeboat Foundation

First-of-its-kind study shows how engineered immune cells move faster to attack the tumor.

A groundbreaking study led by engineering and medical researchers at the University of Minnesota Twin Cities shows how engineered immune cells used in new cancer therapies can overcome physical barriers to allow a patient’s own immune system to fight tumors. The research could improve cancer therapies in the future for millions of people worldwide.

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Scientists have successfully grown a bundle of human stem cells into a tiny artificial “heart” the size of a sesame seed.

The pulsating mass is the first self-organizing miniature organ to resemble the human heart, including a hollow chamber enclosed by a wall of cardiac-like tissue.

Simple heart-like organs, or cardioids, have been built in the lab before, but only using a scaffold, a mold, or a matrix for the cells to assemble around.

Artificial intelligence tool can be used for long-term tracking and management of chronic gastrointestinal ailments.

An artificial intelligence tool under development at Duke University can be added to the standard toilet to help analyze patients’ stool and give gastroenterologists the information they need to provide appropriate treatment, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. The new technology could assist in managing chronic gastrointestinal issues such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).

“Typically, gastroenterologists have to rely on patient self-reported information about their stool to help determine the cause of their gastrointestinal health issues, which can be very unreliable,” said Deborah Fisher, MD, one of the lead authors on the study and associate professor of medicine at Duke University Durham, North Carolina. “Patients often can’t remember what their stool looks like or how often they have a bowel movement, which is part of the standard monitoring process. The Smart Toilet technology will allow us to gather the long-term information needed to make a more accurate and timely diagnosis of chronic gastrointestinal problems.”

Last July, when her immediate family tested positive for Covid-19, Breanna Aguilar did not fit into any groups considered at higher risk for severe disease.

She is 31 years old, a pet sitter and former fitness teacher who once ran a half marathon. She was, by most measures, healthy.

When Aguilar got Covid-19 she lost her sense of taste, had mild fevers and muscle weakness. She could barely keep anything down yet gained about 30 pounds. Later, she developed pelvic pain, cystic acne, breast tenderness, headaches, brain fog and extreme fatigue.

A research group working at Uppsala University has succeeded in studying ‘translation factors’ – important components of a cell’s protein synthesis machinery – that are several billion years old. By studying these ancient ‘resurrected’ factors, the researchers were able to establish that they had much broader specificities than their present-day, more specialized counterparts.

In order to survive and grow, all cells contain an in-house protein synthesis factory. This consists of ribosomes and associated translation factors that work together to ensure that the complex protein production process runs smoothly. While almost all components of the modern translational machinery are well known, until now scientists did not know how the process evolved.

The new study, published in the journal Molecular Biology and Evolution, took the research group led by Professor Suparna Sanyal of the Department of Cell and Molecular Biology on an epic journey back into the past. A previously published study used a special algorithm to predict DNA sequences of ancestors of an important translation factor called elongation factor thermo-unstable, or EF-Tu, going back billions of years. The Uppsala research group used these DNA sequences to resurrect the ancient bacterial EF-Tu proteins and then to study their properties.

Combining self-assembly techniques from across scientific disciplines could allow us to precisely build any material structure.

Nanocars are an impressive achievement – but nanoarchitectonics can unlock a far greater range of material structures.

In a lecture at the American Physical Society in 1959 titled ‘There’s Plenty of Room at the Bottom’, Richard Feynman argued that huge possibilities come from working in the world of molecules and atoms. He dreamed of ultra-small computers, cars running under a microscope, and medical machines working in our body.

Continue reading “Exploring the potential of nanoarchitectonics” »

Einstein, who was not involved in the study, noted that the number of LEEP procedures performed per year in the U.S. — approximately 500000 — indicates the scope of the disease. Additionally, he pointed out that due to the association between LEEP and preterm births, “it is truly important to explore these nonsurgical agents.”

Imiquimod directly activates innate immune cells through Toll-like receptors 7 and 8, resulting in production of cytokines and interferons.

Fonseca and colleagues evaluated the histologic response of cervical HSIL — defined as regression to cervical intraepithelial neoplasia (CIN) 1 — after topical application of 5% imiquimod cream.

Wines and table grapes exist thanks to a genetic exchange so rare that it’s only happened twice in nature in the last 6 million years. And since the domestication of the grapevine 8000 years ago, breeding has continued to be a gamble.

When today’s growers cultivate new varieties – trying to produce better-tasting and more disease-resistant grapes – it takes two to four years for breeders to learn whether they have the genetic ingredients for the perfect flower.

Females set fruit, but produce sterile pollen. Males have stamens for pollen, but lack fruit. The perfect flower, however, carries both sex genes and can self-pollinate. These hermaphroditic varieties generally yield bigger and better-tasting berry clusters, and they’re the ones researchers use for additional cross-breeding.

DNA was personified in Jurassic Park, where the animated double helix that called himself Mr. DNA took you and a group of skeptical scientists through the oversimplified (and obviously fictional) steps to creating dino DNA — but there is some reality in this.

For all you dinosaur enthusiasts out there, synthesizing DNA can’t bring T.Rex and Brachiosaurus back from extinction. Though creating genes in a lab sounds like the original eureka moment of Jurassic Park, synthesizing human DNA has done everything from genetic sequencing and editing to detecting diseases like the current plague we are living through. There is just one step that has always been problematic.