Lifeboat Foundation

Summary: Newly synthesized compounds can halt the degradation of neurons in a range of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, researchers say.

Source: Ural Federal University

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer’s, Parkinson’s, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

Continue reading “Chemists Found an Effective Remedy for ‘Aged’ Brain Diseases” »

“In this study, for the first time, we see evidence that events which were always assumed to be occurring in the same manner, regardless of sex, may actually be completely different in males compared to females. The fact that these differences involve astrocytes, which have traditionally been ignored in neuroscience but have recently become a hot topic for study, makes them all the more intriguing.”

Summary: Thrombospondin-2, a protein with cell adhesion properties usually secreted by astrocytes, prompted a strong increase in synapses in male-derived neurons but showed no effect in females.

Source: Marshall University

Continue reading “Non-Neuronal Cells Drive Sex Differences in Early Brain Development” »

All cancers fall into just two categories, according to new research from scientists at Sinai Health, in findings that could provide a new strategy for treating the most aggressive and untreatable forms of the disease.

In new research out this month in Cancer Cell, scientists at the Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health, divide all cancers into two groups, based on the presence or absence of a protein called the Yes-associated protein, or YAP.

Rod Bremner, senior scientist at the LTRI, said they have determined that all cancers are present with YAP either on or off, and each classification exhibits different drug sensitivities or resistance. YAP plays an important role in the formation of malignant tumours because it is an important regulator and effector of the Hippo signaling pathway.

New research out of the University of California, San Francisco has given a paralyzed man the ability to communicate by translating his brain signals into computer generated writing. The study, published in The New England Journal of Medicine, marks a significant milestone toward restoring communication for people who have lost the ability to speak.

“To our knowledge, this is the first successful demonstration of direct decoding of full words from the brain activity of someone who is paralyzed and cannot speak,” senior author and the Joan and Sanford Weill Chair of Neurological Surgery at UCSF, Edward Chang said in a press release. “It shows strong promise to restore communication by tapping into the brain’s natural speech machinery.”

Some with speech limitations use assistive devices–such as touchscreens, keyboards, or speech-generating computers to communicate. However, every year thousands lose their speech ability from paralysis or brain damage, leaving them unable to use assistive technologies.

A team of researchers from the University of Maryland has 3D printed a soft robotic hand that is agile enough to play Nintendo’s Super Mario Bros. — and win!

The feat, highlighted on the front cover of the latest issue of Science Advances, demonstrates a promising innovation in the field of soft robotics, which centers on creating new types of flexible, inflatable robots that are powered using water or air rather than electricity. The inherent safety and adaptability of soft robots has sparked interest in their use for applications like prosthetics and biomedical devices. Unfortunately, controlling the fluids that make these soft robots bend and move has been especially difficult—until now.

The key breakthrough by the team, led by University of Maryland assistant professor of mechanical engineering Ryan D. Sochol, was the ability to 3D print fully assembled soft robots with integrated fluidic circuits in a single step.

Mysterious strands of DNA that seemingly assimilate genes from many different organisms in their surrounding environment have been discovered in a Californian backyard.

Scientists have named these elements “Borgs”, and their discovery could help us not just understand the evolution of microorganisms, but their interactions within their ecosystems, and their role in the broader environment.

According to geomicrobiologist Jill Banfield from the University of California, Berkeley, Borgs could make for a tremendously significant discovery.

Encouraging Mid Trial data update! Great to know Dr. Katcher is applying for IRB approval for their human clinical trial for E5.

In this video we provide an update on Dr. Katcher’s experiment where he is treating rats with E5 (formerly called Elixer) on a regular schedule to see how long they will live for. Dr Katcher’s team have kindly provided some intermediate updates that we share in the video.
0:00 — 00:50 Introduction.
00:51 — 04:02 Project Background/Overview.
04:03 — Project Update.

Continue reading “Reverse Aging of 54% Study Extension — Dr. Harold Katcher’s E5 Project Update July 2021” »

TAIPEI —Taiwan Semiconductor Manufacturing Co Ltd (TSMC) signalled on Thursday plans to build new factories in the United States and Japan, riding on a pandemic-led surge in demand for chips that power smartphones, laptops and cars.

TSMC, which posted record quarterly sales and forecast higher revenue for the current quarter, said it will expand production capacity in China and does not rule out the possibility of a “second phase” expansion at its $12 billion factory in Arizona.

The world’s largest contract chipmaker and a major Apple supplier also said it is currently reviewing a plan to set up a speciality technology wafer fabrication plant, or fab, in Japan.

NYU Abu Dhabi (NYUAD) researchers have uncovered a code that sets the genome of the liver to account for the remarkable ability for this organ to regenerate. This finding offers new insight into how the specific genes that promote regeneration can be activated when part of the liver is removed. These findings have the potential to inform the development of a new form of regenerative medicine that could help non-regenerative organs regrow in mice and humans.

While other animals can regenerate most organs, humans, mice, and other mammals can only regenerate their liver in response to an injury or when a piece is removed. NYUAD researchers hypothesized that the genes that drive regeneration in the liver would be controlled by a specific code that allows them to be activated in response to injury or resection. They home in on the epigenome, which is the modifications on the DNA that alter the gene expression, as opposed to changing the genetic code itself.

Using a mouse liver model, the team of NYUAD researchers, led by Professor of Biology Kirsten Sadler Edepli, identified the elements of the epigenetic code present in quiescent liver cells—cells that are currently not replicating but have the ability to proliferate under the right conditions—that activate specific genes to regenerate. Genes involved in liver cell proliferation are silenced in livers that are not regenerating, but the surprising finding was that they reside in parts of the genome where most genes are active. The researchers found that these pro-regenerative genes were marked with a specific modification—H3K27me3. During regeneration, H3K27me3 is depleted from these genes, enabling their dynamic expression and driving proliferation.