Lifeboat Foundation

An international team of scientists says it has sequenced and assembled the entirety of the human genome, including parts that were missed in the sequencing of the first human genome two decades ago.

The claim, if confirmed, surpasses the achievement laid out by leaders from the Human Genome Project and Celera Genomics on the White House lawn in 2000, when they announced the sequencing of the first draft human genome. That historic draft, and subsequent human DNA sequences, have all missed about 8% of the genome.

The sequencing of the new genome fills in these gaps using new technology. It has different limitations, however, including the type of cell line that the researchers used in order to speed up their effort.

Circa 2015 brain immortality through aldehyde stabilized cryopreservation.

We describe here a new cryobiological and neurobiological technique, aldehyde-stabilized cryopreservation (ASC), which demonstrates the relevance and utility of advanced cryopreservation science for the neurobiological research community. ASC is a new brain-banking technique designed to facilitate neuroanatomic research such as connectomics research, and has the unique ability to combine stable long term ice-free sample storage with excellent anatomical resolution. To demonstrate the feasibility of ASC, we perfuse-fixed rabbit and pig brains with a glutaraldehyde-based fixative, then slowly perfused increasing concentrations of ethylene glycol over several hours in a manner similar to techniques used for whole organ cryopreservation. Once 65% w/v ethylene glycol was reached, we vitrified brains at −135 °C for indefinite long-term storage. Vitrified brains were rewarmed and the cryoprotectant removed either by perfusion or gradual diffusion from brain slices. We evaluated ASC-processed brains by electron microscopy of multiple regions across the whole brain and by Focused Ion Beam Milling and Scanning Electron Microscopy (FIB-SEM) imaging of selected brain volumes. Preservation was uniformly excellent: processes were easily traceable and synapses were crisp in both species. Aldehyde-stabilized cryopreservation has many advantages over other brain-banking techniques: chemicals are delivered via perfusion, which enables easy scaling to brains of any size; vitrification ensures that the ultrastructure of the brain will not degrade even over very long storage times; and the cryoprotectant can be removed, yielding a perfusable aldehyde-preserved brain which is suitable for a wide variety of brain assays.

Summary: A study in fruit fly models of autism reveals sleep disruption associated with the neurodevelopmental disorder is associated with elevated levels of serotonin. The origin of the higher levels of serotonin was discovered to be in glial cells in the blood-brain barrier.

Source: Radboud University.

Bad sleep causes severe health issues and affects our ability to concentrate, memorize, and cope with challenging situations. Individuals with neurodevelopmental disorders such as autism and intellectual disability, frequently suffer from sleep problems. However, little is known about their underlying mechanisms.

GPU shipments were way up during Q1 as Nvidia, AMD, and others struggle to meet ongoing pandemic-driven demand.

B.1.1.28.2 variant.

India News: The National Institute of Virology, Pune, has detected a new Covid-19 variant — B.1.1.28.2 — through genome sequencing of samples from international t.

New research suggests age-related changes in blood cell chromosomes are a marker of impaired immunity.

A person’s risk of severe infections increases dramatically as they grow older, but scientists do not yet understand how age might be linked to weakened immunity. Now, research shows that certain age-related changes in blood cells are associated with a higher risk of a range of severe infections including severe COVID-19, other pneumonias, and sepsis.

Researchers analyzed genetic and clinical data from nearly 800000 patients from around the world. They discovered that people with a specific type of acquired rearrangement in the chromosomes of their blood cells, called mosaic chromosomal alterations (mCAs), were nearly three times more likely to develop sepsis and two times more likely to get pneumonia than those without mCAs. These genetic changes accumulate in blood cells with age and often indicate a common condition in the elderly called clonal hematopoiesis.

Health, Equity, And Economic Growth — Dr. Helene Gayle, MD, MPH, President and CEO, The Chicago Community Trust.

Dr. Helene D. Gayle, MD, MPH, is President and CEO of The Chicago Community Trust (CCT), one of the nation’s oldest and largest community foundations, and under her leadership, CCT has adopted a new strategic focus on closing the racial and ethnic wealth gap in the Chicago region.

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If hearing the words “military,” “soldier,” and “implant” all in the same sentence conjures images of Jason Bourne, you’re not alone — and with good reason.

The military is currently working with scientists to develop new technology to implant in soldiers. But this time it has less to do with creating superhuman assassins and more to do with quelling jet lag and diarrhea.

In May, researchers from Northwestern University signed a $33 million dollar contract with the Defense Advanced Research Projects Agency (DARPA) to develop a wireless implantable device that will function as a “living pharmacy” for military personnel. It’s called a living pharmacy because everything the “patient” needs can be produced by their own body.

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