Winter and rainly season are worst for those who have chronic cough.even little rain increases throat pain.
This Primer by Mazzone and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of chronic cough and cough hypersensitivity. This Primer also discusses how cough hypersensitivity and chronic cough affect patients’ quality of life and future research directions for the field.
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1].
Different cell types are known to have different shapes and sizes, which are dictated by their functions. In humans, sperm cells (male gametes) and ova (female gametes) have the smallest and largest diameters, respectively. On the other hand, some neurons are the longest cells: their axons can be over a meter long.
Nevertheless, within a specific cell type, the size variation is negligible. It has been long observed that healthy cells tend to maintain their size and that size changes are characteristic of pathological conditions. Cancer cells are often smaller than normal cells, while senescence leads to cellular enlargement [2].
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In this video Professor Sebastiano discusses the results that he and his team have had in rejuvenating human cells and how the process could be applied as well as their experience rejuvenating a muscle in an old mouse.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website.
https://www.turn.bio/
Professor Sebastiano’s lab at Stanford.
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html.
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
https://pubmed.ncbi.nlm.nih.gov/32210226/
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Cryo-electron microscopy by University of Alabama at Birmingham researchers has exposed the structure of a bacterial virus with unprecedented detail. This is the first structure of a virus able to infect Staphylococcus epidermidis, and high-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial infections.
Bacteriophages or “phages” is the terms used for viruses that infect bacteria. The UAB researchers, led by Terje Dokland, Ph.D., in collaboration with Asma Hatoum-Aslan, Ph.D., at the University of Illinois Urbana-Champaign, have described atomic models for all or part of 11 different structural proteins in phage Andhra. The study is published in Science Advances.
Andhra is a member of the picovirus group. Its host range is limited to S. epidermidis. This skin bacterium is mostly benign but also is a leading cause of infections of indwelling medical devices. “Picoviruses are rarely found in phage collections and remain understudied and underused for therapeutic applications,” said Hatoum-Aslan, a phage biologist at the University of Illinois.
Unity CEO Anirvan Ghosh, Ph.D./courtesy of Unity Biotechnology
Senolytic therapies are, at this point, as revolutionary as checkpoint inhibitors but with broader effectiveness. This approach delays the onset of diseases of aging by removing senescent cells from the body, thus enabling people to remain healthier longer or to regain some degree of function lost to disease.
Senolytics is a new field and most of the research is still in academic centers – most notably, the Mayo Clinic. Approval of any therapeutics is years – perhaps even a decade – away.
During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides. Ceramides, known for their use in skin care products, are sphingolipids, a class of fat molecules that are not used to produce energy but rather perform different tasks in the cell.
The researchers found that, in aging, there is an overload of the protein SPT and others, all of which are needed to convert fatty acids and amino acids to ceramides. “The sphingolipids and ceramides are complex yet very interesting fat class, and there is high potential to further study their role in aging, as they perform many diverse functions,” says Dr. Pirkka-Pekka Laurila, a medical doctor and the lead author of the study.
Next, the scientists wanted to see whether reducing ceramide overload could prevent age-related decline in muscle function. They treated old mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used adeno-associated viruses to block ceramide synthesis specifically in muscle. The ceramide blockers prevented loss of muscle mass during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination.
Summary: Researchers identified two FDA-approved drugs that can mitigate or even eliminate the brain fog associated with COVID-19 infection.
Source: Yale.
Individuals with long COVID, sometimes referred to as “long-haulers,” experience symptoms that may persist for weeks, months, or even years after their acute viral infection.
Many investors are jumping to inject money into the startup.
Bill Gates and Jeff Bezos-backed foundations (Gates Frontier and Bezos Expeditions) have joined other companies in investing $75 million in Synchron, the endovascular brain-computer interface (BCI) company, according to a press release by the organization published on Thursday. This is a Series C financing round led by ARCH Venture Partners that brings the total amount raised since inception to $145 million.
Many investors on board.
Additional companies investing are Reliance Digital Health Limited, Greenoaks, Alumni Ventures, Moore Strategic Ventures, and Project X join ARCH as new additional investors.
Synchron through Business Wire.
The funding will serve to support and promote the development of Synchron’s first platform product (Synchron Switch BCI), as well as the beginning of a pivotal clinical trial.
The study shows that machine-learning models can help predict COVID-19 infections.
Researchers have discovered a new way to predict which features are most useful in determining test results for COVID-19. The research team, from Florida Atlantic University’s (FAU) College of Engineering and Computer Science in the U.S., used AI to predict positive or negative COVID-19 test results.
The most common techniques currently used to detect COVID-19 are blood tests, also called serology tests, and molecular tests. Since the two assessments use different methods, they vary substantially.