Lifeboat Foundation

Scientists have long been interested in plasma’s biological implications. In the late 19th century, the Finnish physicist Karl Selim Lemström observed that the width of growth rings in fir trees near the Arctic Circle followed the cycle of the aurora borealis, widening when the northern lights were strongest. He hypothesized that the light show somehow encouraged plant growth. To artificially emulate the northern lights, he placed a metal wire net over growing plants and ran a current through it. Under the right conditions, he reported, the treatment produced larger vegetable yields.

For decades, scientists have known that exposure to plasma can safely kill pathogenic bacteria, fungi and viruses. Small studies in animals also suggest that plasma can prompt the growth of blood vessels in skin. In his research, Reuter studies ways to harness these properties to inhibit new infections in wounds and expedite healing or treat other skin conditions. But more recently, he and other physicists have been working on ways to use the power of plasma to improve food production.

Experiments conducted in the last decade or so have tested a mix of ways to apply plasma to seeds, seedlings, crops and fields. These include plasma generated using noble gases, as well as plasma generated from air. In some cases, plasma is directly applied through plasma “jets” that stream over the seeds or plants. Another approach uses plasma-treated water that can do double duty: irrigation and fertilization. Some studies have reported a range of benefits, from helping plants grow faster and bigger to resisting pests.

Researchers have developed artificial cell-like structures using inorganic matter that autonomously ingest, process, and push out material—recreating an essential function of living cells.

Their article, published in Nature, provides a blueprint for creating “cell mimics,” with potential applications ranging from drug delivery to environmental science.

A fundamental function of living cells is their ability to harvest energy from the environment to pump molecules in and out of their systems. When energy is used to move these molecules from areas of lower concentration to areas of higher concentration, the process is called active transport. Active transport allows cells to take in necessary molecules like glucose or amino acids, store energy, and extract waste.

A newly discovered antibody was able to neutralize not only all strains of COVID-19, but other coronaviruses known to cause respiratory infections in humans — a potential silver bullet for a whole class of deadly, flu-like viruses.

Mutant viruses: As viruses spread, they undergo tiny genetic mutations, and when we find a unique version of the virus, we call it a new strain.

Occasionally, new strains appear that can spread more easily, evade the immune system, or cause more severe disease.

This makes sense, as we believe that inflammation in the central nervous system can start the autoimmune process (when a person’s immune system attacks part of their body) that causes MS.

Summary: A new study links viral infections including mononucleosis and pneumonia experienced during adolescence with an increased risk of developing multiple sclerosis.

Source: The Conversation

Continue reading “Multiple Sclerosis Linked to Infection in Adolescence” »

Thus, the researchers propose that disturbance in the DVC’s timekeeping leads to obesity, rather than being the result of excessive body weight.

When rats are fed a high fat diet, this disturbs the body clock in their brain that normally controls satiety, leading to over-eating and obesity. That’s according to new research published in The Journal of Physiology.

The number of people with obesity has nearly tripled worldwide since 1975.^[1] In England alone, 28% of adults are obese and another 36% are overweight.^[2] Obesity can lead to several other diseases such as Type 2 diabetes, heart disease, stroke, and some types of cancer.^[3]

Continue reading “High Fat Diets Break the Body Clock — This May Be the Underlying Cause of Obesity” »

https://youtube.com/watch?v=8XUFrNQ7YSk

“After demonstrating that cultured meat can reach cost parity faster than the market anticipated, this production facility is the real game-changer,” said Yaakov Nahmias, Future Meat Technologies founder and chief scientific officer, in a press release. “This facility demonstrates our proprietary media rejuvenation technology in scale, allowing us to reach production densities 10-times higher than the industrial standard.”

Cultured meat is made by extracting cells from animal tissue and giving them nutrients, oxygen, and moisture while keeping them at the same temperature they’d be at inside an animal’s body. The cells divide and multiply then start to mature, with muscle cells joining to create muscle fibers and fat cells producing lipids. The resulting nuggets of meat can be used to make processed products like burgers or sausages. Structured cuts of meat with blood vessels and connective tissue, like steak or chicken breast, require scaffolds, and researchers are creating these with biomaterials, like cellulose from plants. Companies are working on several varieties of more elaborate cultured products, from bacon to salmon.

Continue reading “New Cultured Meat Factory Will Churn Out 5,000 Bioreactor Burgers a Day” »

“I think this virus is here to stay with us and it will evolve like influenza pandemic viruses, it will evolve to become one of the other viruses that affects us,” Dr. Mike Ryan, executive director of the World Health Organization’s Health Emergencies Program, said at a press briefing.

Covid-19 could become endemic like the flu and circulate in the population at low levels.

Singapore said the robots, called “Xavier,” can report bad behavior to law enforcement and display messages to “educate” the public.

Circa 23 March 2020

The ways in which a neoplastic cell arises and evades the immune system is the result of a departure from the systems biology that governs health. Understanding this biology requires methods that can resolve the heterogeneity of cell types, determine their states, whether they are activated (e.g., HLA-DR high) or suppressed (e.g., PD-1 high), and map their relationships or distances to one another. MIBI provides single cell resolution and sensitivity to phenotypically characterize the complex tissue environments including the TME. Executed similarly to IHC yet with the capability to profile 40+ markers simultaneously, MIBI is broadly applicable to a wide range of analyses performed in anatomic pathology including cell classification, spatial characterization, and assessment of marker expression. The MIBIscope produces data (multilayer TIFF files) that can be accessed by many analysis platforms currently available, such as those found in commercial software packages such as Fiji, Halo, and VisioPharm or freely available bioinformatic packages developed with open-source programming languages (e.g., R, Python).

All tumor types were stained, imaged, and analyzed using a single staining panel and standardized protocol. The workflow is flexible such that slides can be stained in batches and stored until imaged on the MIBIscope. Stained slides are typically stored under vacuum but protection from light is not necessary as the labels are stable metal isotopes rather than light-sensitive fluorophores. Once imaged it is possible to reimage the tissue as only a modest depth of the tissue is sputtered and analyzed during a single acquisition [16]. One limitation of the current project performed with an earlier version of the MIBIScope is the relatively small FOV size (500 μm by 500 μm) needed for images with 0.5 µm resolution. The current MIBIScope enables FOVs of 800 μm by 800 μm to be imaged in 70 min at fine resolution (650 nm). The resolution can be controlled at the instrument and acquisition at a slightly lower resolution than used in this study (1 μm) can be performed in 17 min. The 800 μm FOV captures 82% of a 1 mm TMA core. FOVs across cores of a TMA can be selected and then imaged in a single run. For whole sections it is possible to acquire adjacent images and stitch the images together using techniques commonly performed with other imaging technologies [22]. The need for tiling is particularly acute for imaging brain sections where multiple FOVs are collected to generate a larger image. Together with researchers at Stanford University, we are currently developing tiling methods to map large regions of brain tissue which will be described in a future publication. Because MIBI is still an early technology, the underlying methods for each stage of the processing pipeline are constantly evolving and improving, not just for accuracy but for generality. While the methods themselves are evolving, the pipeline tasks, at a high level, such as mass calibration, filtering, etc., are defined and have been automated through the MIBI/O software, and, as importantly, allows for appropriate user input when necessary. As more data becomes available, and the user base of MIBI grows, data processing should become more standardized.

Continue reading “Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types” »