Advocates of the fat-but-fit approach to obesity treatment argue that improving fitness, even in the absence of weight loss, can help reduce the risk of cardiovascular disease and mortality.
New research suggests that improving fitness is at least as effective as weight loss for staving off obesity-related cardiovascular disease and mortality risks.
From ecosystem development to talent, much effort is still required for practical implementation of edge AI.
By Pushkar Apte and Tom Salmon
Rapid advances in artificial intelligence (AI) have made this technology important for many industries, including finance, energy, healthcare, and microelectronics. AI is driving a multi-trillion-dollar global market while helping to solve some tough societal problems such as tracking the current pandemic and predicting the severity of climate-driven events like hurricanes and wildfires.
Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain-and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro-or anti-cancer YAP activity functionally defines binary YAPon or YAPoff cancer classes that express or silence YAP, respectively. YAPoff solid cancers are neural/neuroendocrine and frequently RB1−/−, such as retinoblastoma, small cell lung cancer, and neuroendocrine prostate cancer. YAP silencing is intrinsic to the cell of origin, or acquired with lineage switching and drug resistance. The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. Mechanistically, distinct YAP/TEAD enhancers in YAPoff or YAPon cancers deploy anti-cancer integrin or pro-cancer proliferative programs, respectively. YAP is thus pivotal across cancer, but in opposite ways, with therapeutic implications.
Pearson et al. demonstrate that YAP/TAZ, well-known oncogenes, are tumor suppressors in a large group of cancers. Pan-cancer analyses reveal that opposite YAP/TAZ expression, adhesive behavior, and oncogenic versus tumor suppressor YAP/TAZ activity functionally stratify binary cancer classes, which interchange to drive drug resistance. Contrasting YAPoff/YAPon classes exhibit unique vulnerabilities, facilitating therapeutic selection.
Covid: Immune therapy from llamas shows promise.
An immune therapy derived from llama blood shows “exciting potential” in early coronavirus trials.
These club cell-secreted factors are able to nullify immune suppressor cells that otherwise help tumors escape an effective antitumor response,” said co-senior author Dr. Vivek Mittal, director of research at the Neuberger Berman Lung Cancer Center and the Ford-Isom Research Professor of Cardiothoracic Surgery at Weill Cornell Medicine. “We’re excited by the possibility of developing these club cell factors into a cancer treatment.
Malignant tumors can enhance their ability to survive and spread by suppressing antitumor immune cells in their vicinity, but a study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian has uncovered a new way to counter this immunosuppressive effect.
In the study, published Sept. 20 in Nature Cancer, the researchers identified a set of anti-immunosuppressive factors that can be secreted by cells called club cells that line airways in the lungs. They showed in a mouse model of lung cancer that these club cell factors inhibit highly potent immunosuppressive cells called myeloid-derived suppressor cells (MDSCs), which tumors often recruit to help them evade antitumor immune responses.
Continue reading “Scientists find a new way to reverse immune suppression in tumors” »
As this is the first report of neuro-inflammation in Kleefstra syndrome, the next step is to find out if it also occurs in the human condition. Shinkai believes the chances are high and says he would not be surprised if other neurological diseases caused by epigenetic dysregulation were also related to abnormal inflammation in the brain.
Researchers at the RIKEN Cluster for Pioneering Research (CPR) in Japan report that Kleefstra syndrome, a genetic disorder that leads to intellectual disability, can be reversed after birth in a mouse model of the disease. Published in the scientific journal iScience, the series of experiments led by Yoichi Shinkai showed that postnatal treatment resulted in improved symptoms, both in the brain and in behavior.
Normally, we get two good copies of most genes, one from each parent. In Kleefstra syndrome, one copy of the EHMT1 gene is mutated or missing. This leads to half the normal amount of GLP, a protein whose job is to control genes related to brain development through a process called H3K9 methylation. Without enough GLP, H3K9 methylation is also reduced, and the connections between neurons in the brain do not develop normally. The result is intellectual disability and autistic-like symptoms. “We still don’t know if Kleefstra syndrome is a curable disease after birth or how this epigenetic dysregulation leads to the neurological disorder,” says Shinkai. “Our studies in mice have provided new information about what causes the behavioral abnormalities associated with the syndrome and have shown that a cure is a real possibility in the future.”
Continue reading “A genetic brain disease reversed after birth” »
I remember posting about this a year ago in 2020 from UT Austin.
A Covid therapy derived from a llama named Fifi has shown “significant potential” in early trials.
It is a treatment made of nanobodies\.
Continue reading “Covid: Immune therapy from llamas shows promise” »
India is home to 60% of the world’s leprosy patients, and the MIP vaccine is expected to be rolled out in the endemic areas by 2 October 2019.
Science is examining the brain’s neural activity for applications ranging from innovative therapies for brain-related injuries and disease to computational learning architectures for artificial intelligence and deep neural networks.
A research team has developed a tool that lets researchers see more of a live mouse’s brain, to make discoveries that can advance research into the neural circuit mechanisms that form the underlying behavior of the human brain. The tool overcomes the drawback of traditional brain probes—the small amount of tissue they can access, which limits their ability to image neurons of interest.
The innovation is to insert an imaging probe with side-viewing capabilities into a previously inserted optically matched channel—an ultrathin-wall glass capillary—to convert deep brain imaging into endoscopic imaging. The operator can freely rotate the probe to image different brain regions, getting a 360-degree view for imaging along the entire length of the inserted probe. This large-volume imaging enables an increase of about 1,000 times in tissue access volume, compared with what is available for imaging at the tip of typical miniature imaging probes.
