Lifeboat Foundation

The robots can tumble up slopes.

A new study investigates tiny tumbling soft robots that can be controlled using rotating magnetic fields. The technology could be useful for delivering drugs to the nervous system. In this latest study, researchers put the robots through their paces and showed that they can climb slopes, tumble upstream against fluid flow and deliver substances at precise locations to neural tissue.

Would you let a tiny MANiAC travel around your nervous system to treat you with drugs? You may be inclined to say no, but in the future, “magnetically aligned nanorods in alginate capsules” (MANiACs) may be part of an advanced arsenal of drug delivery technologies at doctors’ disposal. A recent study in Frontiers in Robotics and AI is the first to investigate how such tiny robots might perform as drug delivery vehicles in neural tissue. The study finds that when controlled using a magnetic field, the tiny tumbling soft robots can move against fluid flow, climb slopes and move about neural tissues, such as the spinal cord, and deposit substances at precise locations.

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Ian Bremmer.

If you could cure genetic diseases by editing DNA sequences, would you?

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For those who dream of visiting Peru’s Machu Picchu, a new virtual reality (VR) exhibit is set to fully immerse guests in the wonders of the UNESCO World Heritage site.

Debuting this October at the Boca Raton Museum of Art in Florida, the Machu Picchu and the Golden Empires of Peru exhibition is the first of its kind, offering a full-motion, 360-degree, interactive VR experience. Guests can expect to experience the ruins of Machu Picchu as if they were there in person, all while also learning about the ancient civilizations of Peru.

In order to preserve this historic site, less than one million visitors are allowed in each year. During the pandemic, that number dropped to approximately 250,000 to allow for social distancing. But with the Machu Picchu and the Golden Empires of Peru exhibition, the goal is for as many people as possible to experience these impressive ruins.

Bioengineers have repurposed a “non-working” CRISPR system to make a smaller version of the genome engineering tool. Its diminutive size should make it easier to deliver into human cells, tissues and the body for gene therapy.

Summary: Novel AI technology allows researchers to understand which brain regions directly interact with each other, which helps guide the placement of electrodes for DBS to treat neurological diseases.

Source: Mayo Clinic.

For millions of people with epilepsy and movement disorders such as Parkinson’s disease, electrical stimulation of the brain already is widening treatment possibilities. In the future, electrical stimulation may help people with psychiatric illness and direct brain injuries, such as stroke.

Antibacterial, antifungal, antiviral, and antiparasitic treatments developed in the past century have improved survival outcomes, even in high-mortality conditions such as sepsis, a condition that is mostly caused by bacteria but can also be due to other infections. In the 21st century, of all therapies that have improved the outcomes of patients with sepsis, the appropriate and early administration of antibiotics has been shown to be the most effective therapy to save lives.… See More.

International research team isolates DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

(ASX: PXS) has announced that its novel topical drug treatment for scarring has delivered positive phase one clinical trial results and will now advance to the next stage of development in patients.

The cumulative effect of reduced PTPN2 activity on both mechanisms was an elevated fluid loss. The researchers proved this defect could be reversed by treating cells lacking PTPN2 with recombinant -; or synthetic -; matriptase.

A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.

The intestinal epithelium, a single layer of cells, plays a critical role in human health by providing a barrier while also allowing nutrient and water absorption. Intestinal epithelial cells are needed for regulating immune function, communicating with the intestinal microbiota, and protecting the gut from pathogen infection -; all of which critically depend on an intact epithelial barrier.

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