Lifeboat Foundation

I may have already posted about this, but this is more data from The Lancet.

Background.

Recent evidence indicates a potential therapeutic role of fluvoxamine for COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to assess the efficacy of fluvoxamine versus placebo in preventing hospitalisation defined as either retention in a COVID-19 emergency setting or transfer to a tertiary hospital due to COVID-19.

Continue reading “Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial” »

Creating a world where no woman has to die giving life — temitayo erogbogbo, global advocacy director, MSD for mothers, merck sharp & dohme.

Mr. Temitayo (Tayo) Erogbogbo, is Global Advocacy Director of MSD for Mothers (https://www.msdformothers.com/), at Merck Sharp & Dohme.

Continue reading “Mr. Temitayo Erogbogbo, Global Advocacy Director, MSD for Mothers (Merck Sharp & Dohme)” »

Musk recently sold approximately $7 billion in Tesla stock, which skyrocketed in value during the pandemic and made him the world’s richest man.

In an unprecedented atlas, researchers begin to map how genes are turned on or off in different cells, a step toward better understanding the connections between genetics and disease.

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome. Chromatin is a complex of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

And it can be hacked.

The authors of a new study in Nature Catalysis reprogrammed these blobs—called exosomes—into an army of living nanobioreactors. It’s a seemingly simple process of mix and match: each blob is filled with a different chemical that’s involved in a biological reaction. By bringing two together, the blobs merge into a single squishy container, allowing the two chemicals to react.

The results were explosive. The tiny bioreactors pumped out energy molecules, called ATP, inside living cells. The burst of energy saved injured cells, providing them with a boost of power to fight back against dangerous molecules that otherwise lead to cell death.

𝙎𝙥𝙤𝙣𝙜𝙚 𝙂𝙚𝙣𝙚𝙨 𝙃𝙞𝙣𝙩 𝙖𝙩 𝙩𝙝𝙚 𝙊𝙧𝙞𝙜𝙞𝙣𝙨 𝙤𝙛 𝙉𝙚𝙪𝙧𝙤𝙣𝙨 𝙖𝙣𝙙 𝙊𝙩𝙝𝙚𝙧 𝘾𝙚𝙡𝙡𝙨

A new study of gene expression in sponges reveals the complex diversity of their cells as well as some possibly ancient connections between the nervous, immune and digestive systems.

Great video of vital biomolecular processes.

COVID-19 mRNA vaccines deliver directions to make a protein that educates our immune system, so it will neutralize the virus in future encounters. The mRNA-containing lipid particles are taken up by specialized immune system cells. See more: COVIDVaccineAnswers.org

Continue reading “How COVID-19 mRNA Vaccines Work — Vaccine Makers Project” »

In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome inactivation have been murky, but scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have now taken a major step forward in understanding the process.

Their findings, based on research on mouse stem cells, upend previous assumptions about how X inactivation is initiated in female embryos and could lead to new ways to treat some genetic disorders, as well as a better understanding of how genes on other chromosomes are silenced.

“X inactivation is one of the most fundamentally important processes in development, and I think this study is a slam dunk in finally understanding it,” said Kathrin Plath, a professor of biological chemistry and senior author of the paper, published in the journal Cell.

“Shark Tank” investor Kevin O’Leary defended Tesla CEO Elon Musk’s massive fortune in an interview on “Real Time with Bill Maher” on Saturday.

The O’Leary Funds boss — whose nickname is “Mr Wonderful” — also attributed the recent surge in asset prices to aggressive fiscal stimulus, and predicted that many people who worked from home during the pandemic won’t return to their companies’ offices.