Researchers create DNA-based nanopores that switch between three sizes, allowing selective molecule transport across membranes for potential drug delivery and biosensing applications.
In a scientific breakthrough, an international research team from Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.
The research team utilized the expertise of bottom up single-molecule fabrication from the Jülich group while conducting experiments at QNS, utilizing the Korean team’s leading-edge instrumentation and methodological know how, to develop the world’s first quantum sensor for the atomic world.
The diameter of an atom is a million times smaller than the thickest human hair. This makes it extremely challenging to visualize and precisely measure physical quantities like electric and magnetic fields emerging from atoms. To sense such weak fields from a single atom, the observing tool must be highly sensitive and as small as the atoms themselves.
Teleology the return of Aristotle?
The scientific story of who we are is a reductionist, gene-centric model that forfeits natural phenomena like purpose due to its association with intelligent design and a transcendent, intelligent designer. Noble is neutral on religious matters. Yet he sees compelling evidence that purpose may be fundamental to life. He’s determined to debunk the current scientific paradigm and replace the elevated importance of genes with something much more controversial. His efforts have enraged many of his peers but gained support from the next generation of origins-of-life researchers working to topple the reign of gene-centrism. If successful, the shift could not only transform how we classify, study and treat disease, but what it means to be alive.
One of the earliest biomedical computer programmers, Noble created the first model for a working human heart in 1960 on a vacuum tube computer. The project led to his discovery that heartbeats are emergent properties—new phenomena—arising from feedback loops, transforming our understanding of heart function and underpin treatments for heart conditions that we use today. His research on the heart’s pacemaker demonstrates a prioritization of the organism as a whole over its genes alone. “Several genes could individually be knocked out but the process continues,” says Noble. These genes are responsible for heart rhythm, yet other mechanisms can take over to get the job done.
Continue reading “Evolution May Be Purposeful And It’s Freaking Scientists Out” »
The Nazca Mummies have to be amongst the most controversial topics in recent human history, they have been “debunked” multiple times since they were first discovered by Archeologist Thierry Jamin from Peru’s Inkarri institute. Given that this case needed more eyes from the international community, Thierry and Peruvian journalist Jois Mantilla agreed to associate themselves with Mexican journalist Jaime Maussan. What they wanted became a reality, but the movedidn’t come with not obstacles. Nearly seven years after the bodies were discovered from an undisclosed location in the Nazca region, there are still a majority of scientists and academia members who dismiss these bodies as fake. None of them have studied the specimens in person. So far, every scientist who comes close to these bodies and studies them has stated they are real bodies of once living beings.
Carbon 14 test results confirmed these specimens’ remains are from various times in the distant past, some are 1,000+ years old and others are between 1,500 and 2,000 years old. Despite the Carbon 14 test results, the x-rays, and other types of scans that show incredible evidence. There are still many from the mainstream scientific community who believe we won’t get to prove these bodies are real until we get resuls from an extensive DNA analysis that is taking place in lultiple places around the world. Because Jaime Maussan’s involvement did bring more eyes on these bodies, and multiple labs are already running tests on samples obtained directly from the two sources in Peru that have them.
A new study by scientists at deCODE Genetics shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and other human traits.
The research is published in the journal Nature Genetics under the title “The correlation between CpG methylation and gene expression is driven by sequence variants.”
Nanopore sequencing is a new technology developed by ONT (Oxford Nanopore Technology), that enables us to analyze DNA sequences in real-time. With this technology, DNA molecules are drawn through tiny protein pores, and real-time measurements of electric current indicate which nucleotides in the DNA have passed through the pores. This allows the sequence of nucleotides in the DNA to be read, while also making it possible to detect chemical modifications of the nucleotides from these same measurements.
The Cartesian model of mind-body dualism concurs with religious traditions. However, science has supplanted this idea with an energy-matter theory of consciousness, where matter is equivalent to the body and energy replaces the mind or soul. This equivalency is analogous to the concept of the interchange of mass and energy as expressed by Einstein’s famous equation [Formula: see text]. Immanuel Kant, in his Critique of Pure Reason, provided the intellectual and theoretical framework for a theory of mind or consciousness. Any theory of consciousness must include the fact that a conscious entity, as far as is known, is a wet biological medium (the brain), of stupendously high entropy. This organ or entity generates a field that must account for the “binding problem”, which we will define. This proposed field, the conscious electro-magnetic information (CEMI) field, also has physical properties, which we will outline. We will also demonstrate the seamless transition of the Kantian philosophy of the a priori conception of space and time, the organs of perception and conception, into the CEMI field of consciousness. We will explore the concept of the CEMI field and its neurophysiological correlates, and in particular, synchronous and coherent gamma oscillations of various neuronal ensembles, as in William J Freeman’s experiments in the early 1970s with olfactory perception in rabbits. The expansion of the temporo-parietal-occipital (TPO) cortex in hominid evolution epitomizes metaphorical and abstract thinking. This area of the cortex, with synchronous thalamo-cortical oscillations has the best fit for a minimal neural correlate of consciousness. Our field theory shifts consciousness from an abstract idea to a tangible energy with defined properties and a mathematical framework. Even further, it is not a coincidence that the cerebral cortex is very thin with respect to the diameter of the brain. This is in keeping with its fantastically high entropy, as we see in the event horizon of a black hole and the conformal field theory/anti-de Sitter (CFT/ADS) holographic model of the universe. We adumbrate the uniqueness of consciousness of an advanced biological system such as the human brain and draw insight from Avicenna’s gendanken, floating man thought experiment. The multi-system high volume afferentation of a biological wet system honed after millions of years of evolution, its high entropy, and the CEMI field variation inducing currents in motor output pathways are proposed to spark the seeds of consciousness. We will also review Karl Friston’s free energy principle, the concept of belief-update in a Bayesian inference framework, the minimization of the divergence of prior and posterior probability distributions, and the entropy of the brain. We will streamline these highly technical papers, which view consciousness as a minimization principle akin to Hilbert’s action in deriving Einstein’s field equation or Feynman’s sum of histories in quantum mechanics. Consciousness here is interpreted as flow of probability densities on a Riemmanian manifold, where the gradient of ascent on this manifold across contour lines determines the magnitude of perception or the degree of update of the belief-system in a Bayesian inference model. Finally, the science of consciousness has transcended metaphysics and its study is now rooted in the latest advances of neurophysiology, neuro-radiology under the aegis of mathematics.
Keywords: anatomy & physiology; brain anatomy; disorders of consciousness; philosophy.
Copyright © 2020, Kesserwani et al.
The project, led by Professor Zhiqin Chu from the Department of Electrical and Electronic Engineering at the University of Hong Kong (HKU), and Professor Qiang Wei from Sichuan University, utilized label-free quantum sensing technology to measure cellular force at the nanoscale. This advancement surpasses the limitations of traditional cellular force measurement tools and provides new insights into cellular mechanics, particularly regarding how cellular adhesion forces affect cancer cell spreading.
The research team has developed a new Quantum-Enhanced Diamond Molecular Tension Microscopy (QDMTM) that offers an effective approach for studying cell adhesion forces. Compared to cell force measurement methods that utilize fluorescent probes, QDMTM has the potential to overcome challenges such as photobleaching, limited sensitivity, and ambiguity in data interpretation. Furthermore, QDMTM sensors can be cleaned and reused, enhancing the absolute accuracy of comparing cell adhesion forces across various samples.
New studies on astronauts and space biology bring humanity one step closer to the final frontier.
The Space Omics and Medical Atlas (SOMA) package of manuscripts, data, protocols, and code represents the largest-ever compendium of data for aerospace medicine and space biology.
In Arizona, cases of valley fever — a disease spread by a fungus that lives in the dirt — have more than doubled in the past year, 12News reported. The spike in cases may be related to conditions brought about by the ongoing overheating of our planet, officials said.
Valley fever is a lung infection that causes symptoms similar to those that come with pneumonia. These symptoms include fatigue, cough, fever, headache, shortness of breath, night sweats, muscle aches, and rash, according to the Centers for Disease Control and Prevention.
