Lifeboat Foundation

In their quest to discover effective new medicines, scientists search for drug-like molecules that can attach to disease-causing proteins and change their functionality. It is crucial that they know the 3D shape of a molecule to understand how it will attach to specific surfaces of the protein.

But a single molecule can fold in thousands of different ways, so solving that puzzle experimentally is a time consuming and expensive process akin to searching for a needle in a molecular haystack.

MIT researchers are using machine learning to streamline this complex task. They have created a deep learning model that predicts the 3D shapes of a molecule solely based on a graph in 2D of its molecular structure. Molecules are typically represented as small graphs.

Very technical and it’s from the usually secretive Calico.

Jacob Kimmel of Calico Labs discusses how cells can be reprogrammed to restore youthful expression through transient suppression of cell identity at Lifespan.io’s 2021 EARD conference.

Continue reading “Reversing Cell Age, Suppressing Cell Identity, Can Ontogeny Be Reversed? — Jacob Kimmel Lifespan.IO” »

Looking for science fiction books to read? Here are my reviews of some excellent science fiction novels (more to come as well). I encourage you to utilize my reviews to help inform your decisions about your next literary adventure!

PDF version: Science Fiction Book Reviews – Logan Thrasher Collins

Station Eleven by Emily St. John Mandel: 98/100. Much of the essence of art is to reflect what makes us human, helping us better explain to ourselves what makes us tick. Station Eleven is a science fiction novel about a deadly flu pandemic which brings about the end of the world. Notably, it was written several years prior to the emergence of COVID-19. Emily St. John Mandel wields the premise masterfully to touch our souls and help us come to terms with human kindness, cruelty, hope, and vulnerability. Through its deep tragedy and heartfelt characters, the book manages to link questions of the individual and the global. We take a hard look at how the meaning of civilization connects to the meaning of life. Emily St. John Mandel’s prose puts billions to death. Those who survive must find purpose against the backdrop of the visceral viciousness of the apocalypse.

Continue reading “Science Fiction Book Reviews” »

Bitcoin Vs Gold: Peter Schiff Vs Anthony Scaramucci.

Peter Shiff makes several points about gold:

Continue reading “Debate: Bitcoin vs Gold with Anthony Scaramucci and Peter Schiff” »

As we age, our muscles gradually become smaller, weaker and less able to heal after injury. In a new study, UPMC and University of Pittsburgh researchers pinpoint an important mediator of youthfulness in mouse muscle, a discovery that could advance muscle regeneration therapies for older people.

Published today in Nature Aging, the study demonstrates that circulating shuttles called extracellular vesicles, or EVs, deliver genetic instructions for the longevity protein known as Klotho to muscle cells. Loss of muscle function and impaired muscle repair in old mice may be driven by aged EVs, which carry fewer copies of these instructions than those in young animals.

The findings are an important advance in understanding why the capacity for muscles to regenerate dwindles with age.

Dubbed an ‘intelligent bomb,’ this biotechnology marks an advance in senolytics, which aims to remove harmful, zombie-like cells from the body.

Inspired by the mastery of artificial intelligence (AI) over games like Go and Super Mario, scientists at the National Synchrotron Light Source II (NSLS-II) trained an AI agent — an autonomous computational program that observes and acts — how to conduct research experiments at superhuman levels by using the same approach. The Brookhaven team published their findings in the journal Machine Learning: Science and Technology and implemented the AI agent as part of the research capabilities at NSLS-II.

As a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE’s Brookhaven National Laboratory, NSLS-II enables scientific studies by more than 2000 researchers each year, offering access to the facility’s ultrabright x-rays. Scientists from all over the world come to the facility to advance their research in areas such as batteries, microelectronics, and drug development. However, time at NSLS-II’s experimental stations — called beamlines — is hard to get because nearly three times as many researchers would like to use them as any one station can handle in a day — despite the facility’s 24/7 operations.

“Since time at our facility is a precious resource, it is our responsibility to be good stewards of that; this means we need to find ways to use this resource more efficiently so that we can enable more science,” said Daniel Olds, beamline scientist at NSLS-II and corresponding author of the study. “One bottleneck is us, the humans who are measuring the samples. We come up with an initial strategy, but adjust it on the fly during the measurement to ensure everything is running smoothly. But we can’t watch the measurement all the time because we also need to eat, sleep and do more than just run the experiment.”

It’s an information age gold rush!

On December 2nd, we brought you the news that Microsoft Research developed a new method that allows it to read and write much faster in DNA format. In the last month or so, three other new developments have popped up in DNA storage.

Scientists at the Center for Synthetic Biology from the Northwestern University, Illinois, have revealed a demonstration on DNA storage encoding that manages to fulfill three bits of information in an hour, according to Technology Networks. This new method “relies on an enzymatic system.”

Continue reading “DNA Storage Is Picking Up Pace, Why Has It Become So Sought After?” »

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

The team, led by Professor Luc Mongeau and Assistant Professor Jianyu Li, developed a new injectable hydrogel for wound repair. The hydrogel is a type of biomaterial that provides room for cells to live and grow. Once injected into the body, the biomaterial forms a stable, porous structure allowing live cells to grow or pass through to repair the injured organs.