Summary: Advancements in brain mapping and the development of new digital tools over the past decade have opened the door to exciting new discoveries in neuroscience and brain sciences.
Source: University of Oslo.
A billion people worldwide suffer from brain diseases such as dementia, addiction and depression. Scientists carrying out brain research at UiO are now contributing to a more efficient utilization of research data by developing 3D brain atlases and new analytic tools.
Is Director of the Division of Research, Innovation and Ventures (DRIVe — https://drive.hhs.gov/) at the Biomedical Advanced Research and Development Authority (https://aspr.hhs.gov/AboutASPR/ProgramOffices/BARDA/Pages/default.aspx), a U.S. Department of Health and Human Services (HHS) office responsible for the procurement and development of medical countermeasures, principally against bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats, as well as pandemic influenza and emerging diseases.
Dr. Patel is committed to advancing high-impact science, building new products, and launching collaborative programs and initiatives with public and private organizations to advance human health and wellness. As the DRIVe Director, Dr. Patel leads a dynamic team built to tackle complex national health security threats by rapidly developing and deploying innovative technologies and approaches that draw from a broad range of disciplines.
Dr. Patel brings extensive experience in public-private partnerships to DRIVe. Prior to joining the DRIVe team, he served as the HHS Open Innovation Manager. In that role, he focused on advancing innovative policy and funding solutions to complex, long-standing problems in healthcare. During his tenure, he successfully built KidneyX, a public-private partnership to spur development of an artificial kidney, helped design and execute the Advancing American Kidney Health Initiative, designed to catalyze innovation, double the number of organs available for transplant, and shift the paradigm of kidney care to be patient-centric and preventative, and included a Presidential Executive Order signed in July 2019. He also created the largest public-facing open innovation program in the U.S. government with more than 190 competitions and $45 million in awards since 2011.
Prior to his tenure at HHS, Dr. Patel co-founded Omusono Labs, a 3D printing and prototyping services company based in Kampala, Uganda; served as a scientific analyst with Discovery Logic, (a Thomson Reuters company) a provider of systems, data, and analytics for real-time portfolio management; and was a Mirzayan Science and Technology Policy Fellow at The National Academies of Science, Engineering, and Medicine. He also served as a scientist at a nanotechnology startup, Kava Technology.
Dr. Patel holds a US patent issued in 2005 and has authored over a dozen peer-reviewed articles in areas such as nanotechnology, chemistry, innovation policy, and kidney health.
Dr. Patel earned his Ph.D. in physical chemistry from the Georgia Institute of Technology, and has a bachelor’s degree in chemistry from Washington University in St. Louis.
Dr. Renee Wegrzyn, Ph.D. is the inaugural director of the Advanced Research Projects Agency for Health (ARPA-H — https://arpa-h.gov/), an agency that supports the development of high-impact research to drive biomedical and health breakthroughs to deliver transformative, sustainable, and equitable health solutions for everyone. ARPA-H’s mission focuses on leveraging research advances for real world impact.
Previously, Dr. Wegrzyn served as a vice president of business development at Ginkgo Bioworks and head of Innovation at Concentric by Ginkgo, where she focused on applying synthetic biology to outpace infectious diseases—including Covid-19—through biomanufacturing, vaccine innovation and biosurveillance of pathogens at scale.
Prior to Ginkgo, Dr. Wegrzyn was program manager in the Biological Technologies Office at DARPA, where she leveraged the tools of synthetic biology and gene editing to enhance biosecurity, promote public health and support the domestic bioeconomy. Her DARPA portfolio included the Living Foundries: 1,000 Molecules, Safe Genes, Preemptive Expression of Protective Alleles and Response Elements and the Detect it with Gene Editing Technologies programs.
Dr. Wegrzyn received the Superior Public Service Medal for her work and contributions at DARPA. Prior to joining DARPA, she led technical teams in private industry in the areas of biosecurity, gene therapies, emerging infectious disease, neuromodulation, synthetic biology, as well as research and development teams commercializing multiplex immunoassays and peptide-based disease diagnostics.
Dr. Wegrzyn holds doctorate and bachelor’s degrees in applied biology from the Georgia Institute of Technology. She was a fellow in the Center for Health Security Emerging Leaders in Biosecurity Initiative and completed postdoctoral training as an Alexander von Humboldt fellow in Heidelberg, Germany.
Students often sacrifice sleep to study for exams, but lack of sleep can negatively impact memory. Now, University of Groningen neuroscientist Robbert Havekes has found that sleep deprivation hinders recall, not retention of information. Havekes and his team used optogenetics and the drug roflumilast to make “hidden knowledge” obtained while sleep-deprived accessible again days later. Their findings were recently published in the journal Current Biology.
Havekes, associate professor of Neuroscience of Memory and Sleep at the University of Groningen, the Netherlands, and his team have extensively studied how sleep deprivation affects memory processes. “We previously focused on finding ways to support memory processes during a sleep deprivation episode”, says Havekes.
However, in his latest study, his team examined whether amnesia as a result of sleep deprivation was a direct result of information loss, or merely caused by difficulties retrieving information.
The “one-shot” process paves the path for cutting-edge 3D cell culture methods with biomedical engineering applications, claim the scientists.
German scientists have created a new technology that helps them print 3D objects with sound waves.
The design creates pressure fields using several acoustic holograms, which can be used to print solid particles, gel beads, and even living cells, according to the study released on Thursday.
Carloscastilla/iStock.
The new method of 3D matter assembly was developed by researchers from the Institute for Molecular Systems Engineering and Advanced Materials and the Micro, Nano, and Molecular Systems Lab at the Max Planck Institute for Medical Research at Heidelberg University.
What’s next?
Increasingly it seems there is nothing that ChatGPT cannot do, even consulting judges in cases and boosting research. Now, the AI chatbot has been found to score at or around the approximately 60 percent passing threshold for the United States Medical Licensing Exam (USMLE), “with responses that make coherent, internal sense and contain frequent insights.”
This is according to a study published on Thursday in the open-access journal PLOS Digital Health.
AndreyPopov/iStock.
Now, the AI chatbot has been found to score at or around the approximately 60 percent passing threshold for the United States Medical Licensing Exam (USMLE), “with responses that make coherent, internal sense and contain frequent insights.”
The doctors explain it as a rare case of foreign accent syndrome.
A man suffering from prostate cancer started sporting an Irish accent in what is one of the few documented reports of the condition and the first ever associated with this type of cancer. Sadly, the man ultimately passed away from his disease.
A rare condition.
StudioM1/iStock.
This is according to a study published late last month in BMJ Case Reports. The man was being treated for an ongoing case of metastatic prostate cancer when he suddenly began to speak with “an uncontrollable ‘Irish brogue’ accent despite no Irish background,” the researchers wrote in their report. They quickly diagnosed him with foreign accent syndrome or FAS.
Rheumatoid arthritis (RA), known as “immortal cancer,” is a chronic, progressive autoimmune inflammatory disease. The development and application of an RA high-sensitivity theranostics probe can help to accurately monitor the progression and realize the efficient treatment of RA.
In a study published in Advanced Science, a research group led by Prof. Zhang Yun from Fujian Institute of Research on the Structure of Matter of the Chinese Academy of Sciences developed a dual-triggered theranostics nanoprobe based on persistent luminescence nanoparticles (PLNPs) for RA autofluorescence-free imaging-guided precise treatment and therapeutic evaluation.
The researchers first prepared a renewable near-infrared (NIR)-emitting Zn1.3 Ga1.4 Sn0.3 O4:0.5%Cr3+, 0.3%Y3+ (ZGSO) PLNPs by a facile mesoporous silica template method.
Robotic systems have become increasingly sophisticated over the past decades, improving both in terms of precision and capabilities. This is gradually facilitating the partial automation of some surgical and medical procedures.
Researchers at Tsinghua University have recently developed a soft robotic tentacle that could potentially be used to improve the efficiency of some standard medical procedures. This tentacle, introduced in IEEE Transactions on Robotics, is controlled through their novel control algorithm, together with the so-called active cooling for shape memory alloy, the actuating candidate for the robot.
“A neurosurgeon doctor one day came to our lab and asked about the possibility of developing a soft, controllable catheter for him to assist him in his neurosurgeries,” Huichan Zhao, one of the researchers who carried out the study, told Tech Xplore. “He would like this soft catheter to be extremely safe to the surroundings and be able to bend to different directions by a remote controller. Starting from these requirements, we developed a soft robotic tentacle.”
Sending a jolt of electricity through a person’s brain can do remarkable things. You only have to watch the videos of people with Parkinson’s disease who have electrodes implanted in their brains. They can go from struggling to walk to confidently striding across a room literally at the flick of a switch.
Stimulating certain parts of the brain can bring people in and out of consciousness. Even handheld devices that deliver gentle pulses to the brain can help older people remember things.
Implants that track and optimize our brain activity are on the way.