Lifeboat Foundation

David Sinclair shares another side of himself. Compassion for all people. He wants to make sure that longevity technologies are available for all people, not just for the super wealthy and their pets. He also speaks of emerging elderly populations who can live well up until death rather than suffering for so long, and instead start new careers and hobbies.

Researchers have restored vision in animal by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, by Dr David Sinclair Lab, published in Nature Dec 2020, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

Continue reading “Boost NAD, Reprogramme Our Cells to be Young Again | Dr David Sinclair Interview Clips” »

The application of mechanic forces to the cell nucleus affects the transport of proteins through the nuclear membrane, an action that controls cellular processes and could play a key role in several diseases such as cancer. These findings draw a new scenario for understanding how the mechanic forces drive the progression of cancer and open the doors to the design of potential innovative techniques—both diagnostic and therapeutic. This is the conclusion of a study published in the journal Nature Cell Biology led by lecturer Pere Roca-Cusachs, from the Faculty of Medicine and Health Sciences of the University of Barcelona, the Institute of Nanoscience and Nanotechnology of the UB (IN2UB) and the Institute for Bioengineering of Catalonia (IBEC).

The cells in the body receive mechanical stimuli from their environment and respond accordingly regarding decisions on how and when to grow, move and differentiate. The process is known as mechanotransduction and it is critically important for the cell function and for human health.

The study reveals that the direct application of force to the nucleus can affect the spatial organization of the DNA and the activity of nuclear proteins, among other functions. When cancer cells invade the organs and metastasis appears, these create physical forces that are transmitted to the cell nucleus.

Gabapentin, which is currently used to control seizures and manage nerve pain, might help nerve cells regrow in the brain.

Holes help make sponges and English muffins useful (and, in the case of the latter, delicious). Without holes, they wouldn’t be flexible enough to bend into small crevices, or to sop up the perfect amount of jam and butter.

In a new study, University of Chicago scientists find that holes can also improve technology, including medical devices. Published in Nature Materials, the paper describes an entirely new way to make a solar cell: by etching holes in the top layer to make it porous. The innovation could form the basis for a less-invasive pacemaker, or similar medical devices. It could be paired with a small light source to reduce the size of the bulky batteries that are currently implanted along with today’s pacemakers.

“We hope this opens many possibilities for further improvements in this field,” said Aleksander Prominski, the first author on the paper.

A major campaign of domino-toppling simulations yields new insights into the effects of friction.

Despite the apparent simplicity of toppling dominoes, physicists still don’t have a complete model of the phenomenon. But new numerical simulations get a step closer by untangling the influence of two types of friction—one between neighboring dominoes and the other between each domino and the surface beneath it [1]. The researchers found that, in some cases, these two friction coefficients play competing roles in determining the speed of the domino cascade. They also found that one of the coefficients behaves similar to friction in granular systems such as piles of sand or pharmaceutical pills, suggesting that the domino simulations may provide insights into other situations where friction is important.

Continue reading “Friction Is Key in Domino Physics” »

Circa 2016

Reports that scientists have created “the first fully living dinosaur embryo in millions of years” using DNA from chicken skin are fake news.

No one should think we are over COVID.

WASHINGTON — Federal health officials warned on Wednesday that a third of Americans live in areas where the threat of Covid-19 is now so high that they should consider wearing a mask in indoor public settings. They cited new data showing a substantial jump in both the spread of the coronavirus and hospitalizations over the past week.

Dr. Rochelle P. Walensky, the director of the Centers for Disease Control and Prevention, said that the seven-day average of hospital admissions from Covid rose 19 percent over the previous week. About 3,000 people a day were being admitted with Covid, she said, although death rates, a lagging indicator, remained low.

Continue reading “Biden Health Officials Warn of Substantial Increase in Virus Cases” »

And researchers have hailed it as a breakthrough.

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Continue reading “Bile Acids: The Next Frontier In Longevity?” »