Previously Fahy has reported as much as a 15 year epigenetic clock reset. Again though, this won’t get you beyond your maximum natural limit, but younger and healthier now leads to the next bridge.
Dr Greg Fahy talks about the thymus magic. What are the out of expectation benefits of reprogramming our thymus(Not TRIIM or TRIIM-X) in this short clip.
Gregory M. Fahy is a cryobiologist and biogerontologist, and is also Vice President and Chief Scientific Officer at Twenty-First Century Medicine, Inc. Fahy is the world’s foremost expert in organ cryopreservation by vitrification. Fahy introduced the modern successful approach to vitrification for cryopreservation in cryobiology and he is widely credited, along with William F. Rall, for introducing vitrification into the field of reproductive biology.
Fahy is also a well-known biogerontologist and is the originator and Editor-in-Chief of The Future of Aging: Pathways to Human Life Extension, a multi-authored book on the future of biogerontology. He currently serves on the editorial boards of Rejuvenation Research and the Open Geriatric Medicine Journal and served for 16 years as a Director of the American Aging Association and for 6 years as the editor of AGE News, the organization’s newsletter.
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The pursuit of a cure for Alzheimer’s disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.
In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, may have been based on fabricated data.
One year earlier, in June 2021, the US Food and Drug Administration had approved aducanumab, an antibody-targeting beta-amyloid, as a treatment for Alzheimer’s, even though the data supporting its use were incomplete and contradictory.
A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. Extracting the duration of tumor evolution can give an accurate predictor of neuroblastoma outcomes.
In a paper published in Nature Genetics titled “Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome,” the team details the steps they took in identifying a genomic clock tested against a whole genome sequenced population combined with analysis and mathematical modeling, to identify evolution markers, traceability and a likely origin point of infant neuroblastomas.
Cancer cells start out life as heroic healthy tissues, with the sort of all for one, one for all, throw yourself on a grenade to save your mates–type attitude that is taking place throughout the body every day. At some point, something goes wrong, and a good cell goes bad.
The use of time-lapse monitoring in IVF does not result in more pregnancies or shorten the time it takes to get pregnant. This new method, which promises to “identify the most viable embryos,” is more expensive than the classic approach. Research from Amsterdam UMC, published today in The Lancet, shows that time-lapse monitoring does not improve clinical results.
Patients undergoing an IVF treatment often have several usable embryos. The laboratory then makes a choice as to which embryo will be transferred into the uterus. Crucial to this decision is the cell division pattern in the first three to five days of embryo development. In order to observe this, embryos must be removed from the incubator daily to be checked under a microscope. In time-lapse incubators, however, built-in cameras record the development of each embryo. This way embryos no longer need to be removed from the stable environment of the incubator and a computer algorithm calculates which embryo has shown the most optimal growth pattern.
More and more IVF centers, across the world, use time-lapse monitoring for the evaluation and selection of embryos. Prospective parents are often promised that time-lapse monitoring will increase their chance of becoming pregnant. Despite frequent use of this relatively expensive method, there are hardly any large clinical studies evaluating the added value of time-lapse monitoring for IVF treatments.
Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.
Mutations in the breast cancer susceptibility gene, BRCA2, can significantly increase an individual’s lifetime risk of developing cancer. Approximately one in every 400 people carry a BRCA gene mutation accounting for a significant proportion of cancer that is heritable. The study was published on March 28 in the Proceedings of the National Academy of Sciences.
“If you carry a BRCA mutation, you have this incredibly high risk for breast and ovarian cancer, and also for men, prostate and pancreatic cancer,” said Yale Cancer Center member and co-author of the paper, Ryan Jensen, Ph.D., who is also an associate professor of therapeutic Radiology at Yale School of Medicine.
Researchers at Boston University, U.S. report that the flow of cerebrospinal fluid in the brain is linked to waking brain activity. Led by Stephanie Williams, and publishing in the open access journal PLOS Biology on March 30, the study demonstrates that manipulating blood flow in the brain with visual stimulation induces complementary fluid flow. The findings could impact treatment for conditions like Alzheimer’s disease, which have been associated with declines in cerebrospinal fluid flow.
Just as our kidneys help remove toxic waste from our bodies, cerebrospinal fluid helps remove toxins from the brain, particularly while we sleep. Reduced flow of cerebrospinal fluid is known to be related to declines in brain health, such as occur in Alzheimer’s disease. Based on evidence from sleep studies, the researchers hypothesized that brain activity while awake could also affect the flow of cerebrospinal fluid. They tested this hypothesis by simultaneously recording human brain activity via fMRI and the speed of cerebrospinal fluid flow while people were shown a checkered pattern that turned on and off.
Researchers first confirmed that the checkered pattern induced brain activity; blood oxygenation recorded by fMRI increased when the pattern was visible and decreased when it was turned off. Next, they found that the flow of cerebrospinal fluid negatively mirrored the blood signal, increasing when the checkered pattern was off. Further tests showed that changing how long the pattern was visible affected blood and fluid in a predictable way, and that the blood-cerebrospinal fluid link could not be accounted for by only breathing or heart rate rhythms.
The number of people under 50 with cancer is increasing in many countries and for many different tumour types. Why this is occurring isn’t entirely clear, but it may be due to some aspects of modern life.
By Clare Wilson
Advanced materials are urgently needed for everyday life, be it in high technology, mobility, infrastructure, green energy or medicine. However, traditional ways of discovering and exploring new materials encounter limits due to the complexity of chemical compositions, structures and targeted properties. Moreover, new materials should not only enable novel applications, but also include sustainable ways of producing, using and recycling them.
Researchers from the Max-Planck-Institut für Eisenforschung (MPIE) review the status of physics-based modelling and discuss how combining these approaches with artificial intelligence can open so far untapped spaces for the design of complex materials.
They published their perspective in the journal Nature Computational Science (“Accelerating the design of compositionally complex materials via physics-informed artificial intelligence”).