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Archive for the ‘bioengineering’ category: Page 51

Dec 12, 2022

Genetically modified mice pave the way for customized medicine in a rare disease

Posted by in categories: bioengineering, biotech/medical, genetics

An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

Patients with mutations in this protein suffer from Allan-Herndon-Dudley syndrome, a that takes the form of serious neurological alterations, in which each patient may reveal a different mutation of MCT8.

This study, published in Neurobiology of Disease, describes the first avatar model for the disease—in other words, the first animal model with the same as various .

Dec 11, 2022

Plant-based air purifiers are coming to your home — The Blueprint

Posted by in categories: bioengineering, genetics

These genetically engineered plants can take over the work of 30 houseplants.

A bioengineered plant is able to clean the air by doing the work of over 30 houseplantsIt could be the start of a bold new industry that develps over the next 15 to 20 years.

The Neo P1 is the first of its kind.

Continue reading “Plant-based air purifiers are coming to your home — The Blueprint” »

Dec 10, 2022

Hugo de Garis — From Nanotech to Femtotech — There’s Plenty More Room at the Bottom

Posted by in categories: bioengineering, biotech/medical, genetics, information science, nanotechnology, robotics/AI

Discusses the possibility of Femtotech and the technological possibilities it may unlock. Not long ago nanotechnology was a fringe topic; now it’s a flourishing engineering field, and fairly mainstream. For example, while writing this article, I happened to receive an email advertisement for the “Second World Conference on Nanomedicine and Drug Delivery,” in Kerala, India. It wasn’t so long ago that nanomedicine seemed merely a flicker in the eyes of Robert Freitas and a few other visionaries!

But nano is not as small as the world goes. A nanometer is 10–9 meters – the scale of atoms and molecules. A water molecule is a bit less than one nanometer long, and a germ is around a thousand nanometers across. On the other hand, a proton has a diameter of a couple femtometers – where a femtometer, at 10–15 meters, makes a nanometer seem positively gargantuan. Now that the viability of nanotech is widely accepted (in spite of some ongoing heated debates about the details), it’s time to ask: what about femtotech? Picotech or other technologies at the scales between nano and femto seem relatively uninteresting, because we don’t know any basic constituents of matter that exist at those scales. But femtotech, based on engineering structures from subatomic particles, makes perfect conceptual sense, though it’s certainly difficult given current technology.

Continue reading “Hugo de Garis — From Nanotech to Femtotech — There’s Plenty More Room at the Bottom” »

Dec 10, 2022

Editing out HIV: application of gene editing technology to achieve functional cure

Posted by in categories: bioengineering, biotech/medical

face_with_colon_three year 2021.


Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects. Graphical Abstract.

Dec 8, 2022

Scientists Create an Artificial Cell With Synthetic Genome

Posted by in categories: bioengineering, biotech/medical

I wrote a foreword for this awesome Sci-Fi book here: https://amzn.to/3aGrg0I
Get a Wonderful Person shirt: https://teespring.com/stores/whatdamath.
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Hello and welcome! My name is Anton and in this video, we will talk about new studies that present a scientific creation of artificial life.
Papers: https://linkinghub.elsevier.com/retrieve/pii/S0092867421002932
https://robotics.sciencemag.org/content/6/52/eabf1571
Old papers: https://science.sciencemag.org/content/329/5987/52?ijkey=844…f_ipsecsha.
https://pubmed.ncbi.nlm.nih.gov/14657399/
Press release and video/images: https://www.uvm.edu/uvmnews/news/team-builds-first-living-robots.
Images:
James Pelletier (MIT Center for Bits and Atoms and Department of Physics) and Elizabeth Strychalski (National Institute of Standards and Technology))
DOUGLAS BLACKISTON, Tufts University.
Otofrog, CC BY-SA 4.0
Charles Daghlian.
Universal Studios, NBCUniversal — Dr. Macro.
www.scientificanimations.com, CC0
IDKlab, CC0

Continue reading “Scientists Create an Artificial Cell With Synthetic Genome” »

Dec 8, 2022

The CRISPR Apostle: Rodolphe Barrangou

Posted by in categories: bioengineering, biotech/medical, drones, food, genetics, health

http://www.iBiology.org.

For millennia, humans have been harnessing #microbes to produce everything from breads, to cheeses, to alcohol. Now these tiny organisms have produced another powerful revolution — the gene editing tool CRISPR. Rodolphe Barrangou, Ph.D., was working at the food company Danisco, where he was trying to produce yogurt lines resistant to contamination. In a series of groundbreaking experiments, he helped uncover what CRISPR was, how it worked, and why it could be so transformative.

Continue reading “The CRISPR Apostle: Rodolphe Barrangou” »

Dec 8, 2022

How to edit the genes of nature’s master manipulators

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics

CRISPR, the Nobel Prize-winning gene editing technology, is poised to have a profound impact on the fields of microbiology and medicine yet again.

A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed —which has long eluded the —could help researchers control microbiomes without antibiotics or harsh chemicals, and treat dangerous drug-resistant infections. A paper describing the work was recently published in Nature Microbiology.

“Bacteriophages are some of the most abundant and diverse biological entities on Earth. Unlike prior approaches, this editing strategy works against the tremendous genetic diversity of bacteriophages,” said first author Benjamin Adler, a postdoctoral fellow in Doudna’s lab. “There are so many exciting directions here—discovery is literally at our fingertips.”

Dec 7, 2022

Bioengineering Breakthrough: New Implant Can Restore Sight to the Blind

Posted by in categories: bioengineering, innovation

This eye implant engineered from proteins in pig skin can restore sight in people with impaired eyesight as well as the blind.

Dec 7, 2022

Biomembrane research findings could advance understanding of computing and human memory

Posted by in categories: bioengineering, biological, computing, health, nanotechnology

While studying how bio-inspired materials might inform the design of next-generation computers, scientists at the Department of Energy’s Oak Ridge National Laboratory achieved a first-of-its-kind result that could have big implications for both edge computing and human health.

Results published in Proceedings of the National Academy of Sciences show that an artificial is capable of long-term potentiation, or LTP, a hallmark of biological learning and . This is the first evidence that a cell membrane alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL.

Dec 7, 2022

Multiple Realizability (Stanford Encyclopedia of Philosophy)

Posted by in categories: bioengineering, biological, chemistry, neuroscience, physics

In the philosophy of mind, the multiple realizability thesis contends that a single mental kind (property, state, event) can be realized by many distinct physical kinds. A common example is pain. Many philosophers have asserted that a wide variety of physical properties, states, or events, sharing no features in common at that level of description, can all realize the same pain. This thesis served as a premise in the most influential argument against early theories that identified mental states with brain states (psychoneural, or mind-brain identity theories). It also served in early arguments for functionalism. Nonreductive physicalists later adopted this premise and these arguments (usually without alteration) to challenge all varieties of psychophysical reductionism. The argument was even used to challenge the functionalism it initially was offered to support. Reductionists (and other critics) quickly offered a number of responses, initially attacking either the anti-reductionist or anti-identity conclusion from the multiple realizability premise, or advocating accounts of the reduction relation that accommodated multiple realizability. More recently it has become fashionable to attack the multiple realizability premise itself. Most recently the first book-length treatment of multiple realizability and its philosophical import has appeared.

This entry proceeds mostly chronologically, to indicate the historical development of the topic. Its principle focus is on philosophy of mind and cognitive science, but it also indicates the more recent shift in emphasis to concerns in the metaphysics of science more generally. It is worth mentioning at the outset that multiple realizability has been claimed in physics (e.g., Batterman 2000), biochemistry (Tahko forthcoming) and synthetic biology (Koskinen 2019a, b). After more than fifty years of detailed philosophical discussion there still seems to be no end in sight for novel ideas about this persistent concern.

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