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Sep 2, 2024

Near‐Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR‐Cas9 Ribonucleoprotein for Brain Gene Editing

Posted by in categories: bioengineering, biotech/medical, chemistry, nanotechnology, neuroscience

A nanoparticle formulation, using oligonucleotide chemistry, able to release a gene editing system with single cell resolution after near infrared laser activation. The full potential of the formulation was demonstrated in the brain after intracerebral and intranasal administrations. The spot of the laser defined the region of gene editing.

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