Lifeboat Foundation

Imagine being able to treat neurodegenerative diseases and mental disorders such as Alzheimer’s disease, Parkinson’s, epilepsy, PTSD, depression, and anxiety with non-invasive light-based therapy. This is the quest of pioneering scientists and researchers in optogenetics, an emerging field in biotechnology that uses light to control cells in living tissues such as neurons, in order to study brain function.

British Nobel laureate Francis Crick of The Salk Institute for Biological Studies in La Jolla, California put forth the concept of the ability to turn the firing of “one or more types of neuron on and off in the alert animal in a rapid manner” by using light as “the ideal signal” in his paper “The impact of molecular biology on neuroscience” published in Philosophical Transactions of the Royal Society B in 1999. Crick noted that his concept might be somewhat “far-fetched.” Yet as improbable as it would seem to the brightest minds in science before the turn of the century, this idea was proven in a little over half a decade.

In optogenetics, scientists add genetic code to target tissue, typically a neuron, which enables it to make light-responsive proteins called opsins. Gero Miesenböck and Boris Zemelman published a study in 2002 titled “Selective photostimulation of genetically charged neurons” in Neuron. They used opsin from the retina of a fruit fly to make a neuron light-sensitive. A year later, they demonstrated the use of heterologous proteins to sensitize neurons to light [1]. Peter Hegemann, Georg Nagel and other researchers published their discovery of phototaxis and photophobic responses of green algae in 2002 [2]. In August 2005, MIT neuroscientist Ed. Boyden, PhD, along with Karl Deisseroth, Feng Zhang, Georg Nagel, and Ernst Bamberg published in Nature Neuroscience a landmark breakthrough in optogenetics, “Millisecond-timescale, genetically targeted optical control of neural activity.

Continue reading “How Light and Genetics may Treat Brain Disorders in the Future” »

Australian scientists use stem cells to create human eye lens cells, and then grow them into eye lenses, giving hope to children with cataracts.

LANGSTON, Okla. (AP) — A 3.0-magnitude earthquake has shaken parts of central Oklahoma.

The U.S. Geological Survey says the quake was recorded at 1:50 p.m. Sunday about 9 miles (15 kilometers) north-northwest of Langston, which is about 43 miles (69 kilometers) north-northwest of Oklahoma City. The temblor was recorded at a depth of about 3 miles (5.5 kilometers).

No injuries or damage were reported. Geologists say damage is not likely in earthquakes below magnitude 4.0.

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Reaching the highest levels of safety for self-driving cars will depend on how well the cars are engineered to know when communications are needed, and to be able to communicate with other cars, with bikes, with people on foot. Where to go? When to walk?

Uber Technologies has filed a patent toward that end, with a discussion on how self-driving cars might communicate with pedestrians.

The patent title is “Light output system for a self-driving vehicle.” The patent applicant is Uber Technologies.

Continue reading “Uber patent application discusses intention signaling system” »

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You may have thought, “Hey, if we’re threatened by an incoming asteroid, we should just nuke it!” You’re not alone: a team of Russian scientists are working on a plot to do so, by detonating miniature asteroids in a lab.

In fact, several groups of researchers are now toying with the idea of asteroid nuking for the sake of planetary defense. The Russian team has even calculated about how much firepower they’d need to perform such a feat.

According to the translated paper published in the Journal of Experimental and Theoretical Physics: “Given the scale factor and the results of laboratory experiments, the undeniable destruction of a chondritic asteroid 200 m in diameter by a nuclear explosion with an energy above 3 Mt was shown to be possible.”

Continue reading “Russian Scientists Are Devising a Plan to Nuke Asteroids” »

Scientists have mapped 6,000 new craters on the Moon with the help of a newly developed technique based on artificial intelligence (AI).

“When it comes to counting craters on the Moon, it’s a pretty archaic method,” said Mohamad Ali-Dib from the University of Toronto, Scarborough in Canada.

“Basically we need to manually look at an image, locate and count the craters and then calculate how large they are based off the size of the image. Here we’ve developed a technique from artificial intelligence that can automate this entire process that saves significant time and effort,” Ali-Dib said.

Continue reading “New technique based on AI finds 6,000 new craters on Moon” »

Researchers are building a case that long before the nervous system works, the brain sends crucial bioelectric signals to guide the growth of embryonic tissues.

All galaxies, no matter how big they are, rotate once every billion years, astronomers have discovered. The Earth spinning around on its axis once gives us the length of a day, and a complete orbit of the Earth around the Sun gives us a year. “It’s not Swiss watch precision. But regardless of whether a galaxy is very big or very small, if you could sit on the extreme edge of its disk as it spins, it would take you about a billion years to go all the way round,” said Gerhardt Meurer, from of the International Centre for Radio Astronomy Research (ICRAR) in Australia.

By using simple maths, you can show all galaxies of the same size have the same average interior density. “Discovering such regularity in galaxies really helps us to better understand the mechanics that make them tick — you won’t find a dense galaxy rotating quickly, while another with the same size but lower density is rotating more slowly,” Meurer said.

Researchers also found evidence of older stars existing out to the edge of galaxies. “Based on existing models, we expected to find a thin population of young stars at the very edge of the galactic disks we studied,” Meurer said.